Journal of

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Rosacea is an inflammatory, chronic and cosmetically annoying common dermatologic disorder which presents with cutaneous telangiectasia, sustained erythema with courses of flares and flushings, papulopustular lesions, ocular involvement or disfigurating phymas. Although there are many relative effective medical therapies, however there are not any promissable treatment. Due to chronic nature of disease and exhausting usage of topical or systemic therapies , we decided to review Pubmed’s literature for non-medical physical therapies, looking for more effective modalities and minimal side effects, particularly in intractable cases.

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Fungi are eukaryotic organisms that potentially have the ability to cause disease in humans and animals. Fungal infections are called mycosis, which are divided into four types of superficial, cutaneous, subcutaneous and systemic, depending on the area of ​​the body involved. Though cutaneous mycoses are rarely life-threatening infections, they can isolate the patient socially due to the disfigurement of the tissues they caused, as a result of which, treatment has always been an important issue. On the other hand the similarity of fungi to mammalian cells led to difficulties in the development of novel antifungal drugs. Consequently, in recent years, extensive efforts have been made to design and develop novel drug delivery systems with better efficacy for drug delivery of conventional anti-fungal drugs. In this study, we compared conventional forms and novel drug delivery systems of a number of antifungal drugs. All studies confirm the relative priority of novel drug delivery systems to conventional forms in terms of penetration, release, and antifungal effects.

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Probiotics are living microorganisms that, when used adequately, have beneficial effects on the host, and their superiority is that they are safe and secure for the host. The use of probiotics in addition to the digestive tract, has been studied in immune function, skin diseases, diabetes, cancer, liver disease, hypertension, urogenital system and oral cavity. In general, probiotics seem to be a promising and safe treatment. Nevertheless, more extensive studies are needed to use probiotics as alternative treatments along with old treatments. In dermatology, there is also a widespread use of probiotics and prebiotics. The use of probiotics has been studied in the treatment of atopic dermatitis, acne, eczema, allergic diseases, skin aging, bacterial and fungal infections, chronic wound healing, including diabetic foot ulcers, with promising results. In this review, papers related to the use of probiotics in the treatment of skin diseases were searched in data bases of Pubmed, Google scholar and Medline. Relevant papers were selected and presented. It is expected that probiotics will be used as complimentary treatment in several skin disorders.

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Acupuncture is an ancient medical procedure that is commonly used. It has been used in China for over two thousand years. Acupuncture has gained increasing interest from the public as well as health professionals for a wide range of disorders. This method works through regulation of qi current (life energy in body). Acupuncture has been introduced recently in dermatology for rejuvenation and treatment of facial wrinkles and improving muscle tone and elasticity. Acupuncture is used for treatment of many medical conditions including skin disorders. Tiny, sterile, needles are inserted along meridian lines and acupuncture points to increase blood circulation. Cosmetic acupuncture is a totally natural and holistic anti-ageing treatment that aims to reduce fine lines and wrinkles. Different mechanisms have been proposed for cosmetic acupuncture, including increasing muscle elasticity, and restoring muscle tone. There have been also evidence of increase in skin moisture and lipid.
 In this method, body points and local facial points are used and usually 10-12 sessions of facial acupunctures are recommended. With the increasing popularity of complementary therapies in the community, acupuncture is also considered as a new therapeutic approach.

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Onychomycosis is a common nail disorder. If left untreated, it may cause nail deformity and nail plate dystrophy. Since nails have aesthetic importance, onychomycosis may have some impact on quality of life by causing a change in the appearance of nail and/or nail dystrophy and by interfering with fine activities carried out by hand. The aim of this review is to evaluate the quality of life in patients with onychomycosis.

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Urticaria is a relatively common skin disease characterized by red or white itchy and transient swellings. In more severe cases, it can reduce level of consciousness and be life-threatening due to swelling of tongue or throat and airway obstruction
In conventional medicine, this disease is treated symptomatic and mainly by antihistamines. Studies have indicated that urticaria is similar to "shara" (a type of skin disease mentioned in Persian medicine) in terms of etiology, description, clinical symptoms and diagnosis. In Persian medicine (Iranian traditional medicine) litrature, efficacy of several medicinal plants for the treatment of "shara" has been explaind.

This study is a review on the effective herbal remedies in the treatment of urticaria based on search in Iranian medicine resources, and conventional medicine litrature. Data were extracted from Iranian medicine textbooks and scientific databases including Google scholar, Pub Med, Web of Science and Scopus. It was found that Iranian medicine scholars have used 48 different medicinal plants to treat and reduce the complications of urticaria and the recent scientific studies have proven antiinflammatory, antioxidant and immune-regulating properties in 45 of these plants.

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Hypertrophic scars and keloids are fibrosis abnormalities associated with the accumulation of collagen and extra cellular matrix components. These scars are caused by abnormal wound healing, which may occur after skin injuries caused by surgery, trauma, burns, etc. and may have a large impact on the patients’ quality of life. Hypertrophic scars and colloids in addition to aesthetic problems can cause functional disruption due to tissue contraction and itching. Large numbers of research are currently being performed in the area of scar prevention or treatment, but since the physiopathological mechanisms of scar formation have not been fully elucidated, the current strategies are still unsatisfactory. In this review, we discuss the recent biological advances in scar formation and current and future strategies for the prevention and treatment of hypertrophic and keloid scars.

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Pruritus is one of the most common problems that is seen separately or in combination with various diseases and has been studied in various medical schools. Its various aspects including definition, pathogenesis, types and treatments have been elaborated and tailored to the basics of each medical perspective. This study investigates the pruritus from modern and Persian medicine perspective.
This study is a library review focusing on the pruritus. Initially related keywords include pruritus, itching, hekka, hives and wheal was searched among the prestigious scientific and reference textbooks, journals and sites of modern and Persian medicine such as Rook's textbook of dermatology, Habif Clinical dermatology, Al-Qanun fi al-Tibb, Zakhireh Kharazmshahi, Teb-e-Akbari, Khulasah al-Hikmah, Kamel al-Sana'a al-Tebbiya, Exir-e A'zam, Tohfe Al-Momenin and Makhzan-al-Advie. Then the necessary material was collected and classified and finally the present article was compiled.
In both medical schools, the charecteristics and function of the skin are described initially, then the causes and mechanisms of pruritus are defined and explained. To facilitate understanding and presenting the subject, appropriate classificationare presented for each view. Also, for the pruritus treatment, appropriate recommendations have been put forward for each patient or condition.
Generally, there is not much difference between the two views, but modern medicine is going more specifically through details. While the Persian medicine discusses more comprehensively. The treatment basis in Persian medicine is based on different individual and environmental conditions.

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A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.

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Burn is one of the most severe traumas experienced in humans with severe pain. Some researches indicate the positive impact of spiritual-religious interventions on different aspects of burn injuries. Therefore, the purpose of the present study was to investigate articles published in domestic and foreign databases on the effect of spirituality and religion on burn patients in Iran. The present study is a review study, all Persian articles in scientific journals that are in internal databases including Database SID, Iranmedex, Magiran, Irandoc and external databases such as Google Scholar, pubmed and indexed in persian were reviewed for the purpose of the study. Out of the reviewed articles, 4 articles were finally identified and evaluated according to the purpose of the study. Studies that did not have the full text were excluded, as well as articles that examined only the prevalence of burns and studies that did not specify how interventions were performed. Findings indicate the positive effect of spiritual-religious interventions on increasing the ability to cope with burn pain. Therefore, it is suggested that spiritual-religious interventions in nursing care be more widely considered.

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Since the beginning of COVID-19 pandemic on December 2019, challenges on economic, political, social, hygiene- therapeutic and life style have emerged in many countries. Many researches are investigating on virus characteristics and its behavior and also preventive and therapeutic measures. Despite the virus not being dermatotropic, several skin manifestations have been observed. In this review, overall informations on this viral infection with focus on skin manifestations are presented.

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COVID-19 was announced pandemic by March 2020. Due to the high prevalence of the disease and its staggering spread, it is very important to identify various manifestations of this viral infection.
The aim of this study is to review published articles about cutaneous involvement of COVID-19 disease.
Cutaneous manifestations are rare in COVID-19 disease and it is essential to recognize these possible skin manifestations in order to detect and treat COVID-19 disease and to prevent further transmission.

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Knowledge about environmental factors that are aggressive to skin has increased in recent years. Although concern previously focused primarily on UVA and UVB, this has broadened to contain damage from pollution, tobacco smoke, other ambient toxins, infrared light, blue light and UVA-II.
This article reviews the negative effects of infrared, blue light and UVA-II on skin. Potential protective actions also are discussed.

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Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents. This review emphasizes the action and resistance mechanisms to antifungal drugs, the search for new agents, drug- resistant genes, and the application of combination therapy and immunomodulators (using cytokines and gamma interferon which can provide novel insights to fighting fungal infections). A comprehensive review study was performed using the keywords including Candida, antifungal drugs and drug resistance in valid medical databases, mainly PubMed. Articles that were most relevant to the purposes of the study were selected and studied. Problems with antifungal resistance and the emergence of resistant strains of fungal has produced an enormous demand for new antifungal agents. The clinical complexity of patients with resistant mycoses prevents an easy approach to the detection, prevention, and management of antifungal drug resistance. Continuing investigation will illustrate the role of susceptibility testing for resistant mycoses and on clinical strategies used to fighting antifungal drug resistance in pathogenic fungi.

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COVID-19 is nowadays a pandemic disease. It affects various aspects of human life including physical and mental health and also socio-economic situations. In this review, we attempt to present a brief selection of abundant published papers about pathogenesis, skin manifestations, treatment challenges in different conditions and prevention.

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Habits since the introduction of the first commercial antiperspirant and deodorant, the use of these products have played an increasing role in a person's personal care. This article studies the physiology of human perspiration and responsible compounds for body odor. It also describes the function, classification, and differences between antiperspirants and deodorants.

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Wounds are any type of tissue dehiscence which can occur on skin, mucosae or connective tissue. After the wound has created, inflammatory process, the immune system changes as well as the skin repair cascade will be activated. To provide a product that can direct the above processes in a desirable repair mechanism will be useful. Studies have shown that aloe vera products, with effects such as increased collagen production, antioxidant and water retaining properties, are good options.
Aloe vera grows mainly in arid regions and this fact can be welcomed in many parts of the world. The use of medicinal herbs also reduces the cost for the health systems. Aloe vera is a plant that does not require much cost for plant and harvest. Besides, the compatibility of aloe vera products with a variety of formulations encourages formulators to use it in the pharmaceutical and cosmetic industries.
In this review, the use of aloe vera in wound management and some skin diseases will be discussed.

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Bed bug (Cimex lectularius) is an nocturnal insect that feeding on human blood at all stages of them life, and known as a human ectoparasite. Bed bug is usually feeding from the face, neck, arms, arms, shoulders, legs, and especially parts of the body that are bare during sleep. Persons reaction differently to bed bug bites and may experience minor itching to severe allergies. Symptoms usually appear after 1 to 24 hours and usually include small red cluster papules less than 5 mm in diameter and at a short distance from each other, with severe inflammation and itching. In general, the most important characteristic of those three points is a linear or curve sequence on the body, which is called “breakfast, lunch and dinner” pattern. There are numerous reports of house infestation and the bite of this blood-feeding insect on the body of persons in the country annually, and in initial the majority of the public is unable to correctly identify the symptoms of bed bug bites. So, this article by presenting the key points can be guide for identifying the bite symptoms of this allergenic insect, by doctors and specialists, especially dermatologists, for the timely treatment of the patient.

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Diode 1470 nm laser is a minimally invasive laser used for skin lifting and tightening. It can reduce laxity and excessive fat tissue. Three patients with facial fat lump due to past facial fat injection treated by this laser in one session.

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Post herpetic neuralgia is a chronic neuropathic pain syndrome that it is characterized by pain in the area of ​​the nerve involved distribution after the disappearance of herpes zoster lesions and it may be persistent, refractory and severe. Various treatments including medication, Botox injections, nerve block and physical modalities have been used in the treatment of this syndrome, each has advantages and disadvantages. One of the most widely used methods today is the use of acupuncture. Acupuncture is a low-complication and reproducible treatment that is gaining more and more place in pain management, especially chronic pain. Studies have shown the effect of acupuncture on reducing pain in post-herpetic neuralgia patients. Different parts of acupuncture can be used to reduce pain. The recommended number of sessions is usually 10 to 12 sessions, lasting 20 to 30 minutes. Due to the beneficial effects of acupuncture and its low complication, this method is recommended as one of the treatment methods for postherpetic neuralgia. In this paper, we review the effect of acupuncture on post herpetic neuralgia.