Zahra Hallaji, Maryam Akhyani, Vahide Lajevardi, Mayade Raeiati Damavandi,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Psoriasis is a chronic papulosquamous
disorder, which affects about 2% of the population. Psoriasis is relatively
common in childhood: more than 10% of cases start before the age of 10. Tha aim
of this study was to compare the clinical characteristics between pediatric-onset
and adult-onset psoriasis in Iranian patients.
Methods: In 2006 and 2007, clinical data were collected
from all patients with psoriasis diagnosis referred to Razi Hospital. They were
categorized into two groups: pediatric-onset psoriasis patients and adult-onset
psoriasis patients. Clinical variables such as number of patients, gender, age
of onset, family history, and stress as a precipitating factor, the first site
of involvement, clinical type and involved sites were compared between the two
group.
Results: From total of 162 patients, 50 patients (33.2%)
were considered as pediatric-onset group. The percentage of males in the
pediatric-onset group was 48% compared with 58.9% in the adult-onset group. In
the pediatric-onset group positive family history was 20% and in the
adult-onset group was 12.5%. Stress as a precipitating factor was nearly the
same in both groups. Plaque type psoriasis was the most common clinical
presentation and the head and neck was the most common site of involvement in
both groups.
Conclusion: Our findings, similar to previous studies
showed that the involvement of female gender, family history and the onset of
psoriasis on the scalp in children were more than adults.
Rezvan Talaee, Mohammadreza Moayeri, Tahereh Mazuchi, Seyed Alireza Moravveji, Mohaddese Ardestani,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Quality of life is a broad concept that reflects an individual’s perspective on the level of life satisfaction experienced in a variety of situations including housing, recreation, environmental conditions, health and job. In this way it is a subjective measure that is affected by factors well beyond health status. To evaluate quality of life in patients with common pigmentation disorders such as vitiligo, melasma, and freckles refer to dermatologic clinics of Kashan University of medical sciences during 2010 and 2011.
Methods: In this cross sectional study, 142 patients with pigmentation disorders, older than 18 years old filled out Dermatology Life Quality Index (DLQI) questionnaire. DLQI questionnaire includes 10 questions regarding feelings, daily activities, leisure, job and education, personal relationship and treatment. Scoring was performed according to Finlay's guidelines. The data were analyzed with t, ANOVA and Pearson correlation tests. The higher the score, the greater the impairment of quality of life.
Results: The mean DLQI score was 5.64 (±5.03). The mean DLQI score in vitiligo was higher than other diseases. In this study score of quality of life in women, patients younger than 25 years old, patients with lesions on exposed areas, and single patients was higher than others, but there was not any significant relationship between quality of life and duration of disease, job, education level and place of residence.
Conclusion: This study showed that skin pigmentation disorders had a significant impact on all aspects of the quality of life, especially on socio-psychological aspect. Therefore, dermatologists should pay attention to the psychological effects of those diseases and try to decrease their extensions and disfigurating effects by various treatment modalities.
Amirhoushang Ehsan, Mahboobe Sadathosseini, Zahra Hallaji, Amirreza Hanifnia, Masoume Rohaneinasab,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Palmoplantar pustulosis is a chronic dermatosis of palms and soles, which is associated with a high recurrence rate and resistance to treatment. Various treatments with different success rates have been used.The purpose of this study was to evaluate the efficacy of local bath PUVA in the treatment of palmoplantar pustulosis.
Methods: In this retrospective study, patients with palmoplantar pustulosis who were treated with local bath PUVA in Phototherapy clinic of Razi Hospital between 2005 and 2009 were evaluated for the therapeutic efficacy of local bath PUVA. Data were analyzed using t and chi-square tests.
Results: Ninety-five patients with a mean age of 44.17 years included in this study. 49.5% of patients were males and 50.5% were females. Mean treatment cessions of patients were 42.5 sessions and mean cumulative dose was 251.8 J/cm2. In 16.8% of cases have very good response was observed. Good, moderate and poor responses were observed in 35.8%, 29.5% and 9.5% of cases, respectively. Treatment failure was observed in 8.4% of patients. Mean cumulative dose in patients with very good response was significantly higher than other response groups, (P=0.016). Mean number of treatment sessions was also significantly higher in that group with comparison with other groups, (P<0.05). Twenty percent of patients withdrawed from the study because of complications. However all complications recovered completely and no long term complications was observed.
Conclusion: This study demonstrated that local bath PUVA is an effective safe treatment for the treatment of palmoplantar pustulosis.
Iman Ahrari, Ladan Dastgheyb, Zahra Ghazi, Maryam-Ol-Sadat Sadati,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Tinea capitis is one of the most common fungal infections in dermatology. Although the new medications and development in social health have reduced its incidence, it is still common in Iran, especially in rural areas. The aim of this study was to describe the frequency of complications of kerion.
Methods: Eighteen affected patients, who were hospitalized in dermatology ward because of kerion, in a 10-year period, were revisited and according to their medical documents, data collection forms were filled.
Results: 61.1% of the patients were younger than 10 years of age and 77.7% were male. The mean disease duration from the onset of symptoms to the time of correct diagnosis and management was 16.9 days. The frequency of scar and alopecia was equal in all groups and occurred in 100% of patients. Two patients also suffered from isolation due to scarring alopecia. Various types of medications, made no difference in the prognosis and resultant scarring alopecia.
Conclusion: The frequency and types of sequela showed no relationship with age, type of medication and duration from the onset of disease and correct management. Scar and alopecia occurred in all patients. Further investigations on the new treatment modalities are required to reduce scar formation.
Hassan Baniasadi,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: The women’s main purpose of cosmetic rhinoplasty is to have a nose that they think has a better harmony with their face, so they could reach to a more desirable body image. This study investigated the effects of cosmetic nose surgery on women`s body image.
Methods: Thirty women referred to the private clinics of cosmetic surgeons for nose cosmetic surgery were selected. The multidimensional body-self relations questionnaire developed by Cash (1998) was employed to measure the women`s body image. This questionnaire was filled out before and five months after rhinoplasty.
Results: Using paired t test, the analyses of the data demostrated that nose cosmetic rhinoplasty increased the levels of women`s satisfaction of their subjective body and subjective nose images (P=0.0001 and , respectively).
Conclusion: The findings of the present study showed that cosmetic nose surgery increases the of levels of women’s satisfaction of their body image and it causes the person to have higher satisfaction of her nose and body image.
Alireza Firooz, Ali Rajabi Estarabadi, Hamed Zartab,
Volume 3, Issue 4 (12-2012)
Abstract
Skin is the largest organ of the integumentary system with multiples important functions. Due to its complex structure, the permeability skin status can be modified by different external and internal factors such as chemical and physical stresses, and several skin and systemic diseases. Today, different non-invasive methods are used to assess the skin barrier biophysical properties. The parameters such as transepidermal water loss, stratum corneum hydration, skin surface pH and skin surface lipids is essential for evaluation of the epidermal barrier status. Application of these methods is critical for evaluation of disease treatments, the effectiveness of topically applied drugs and cosmetic products. The aim of this article is to review application of several methods for skin biophysical and biomechanical properties in humans.
Alireza Khatami,
Volume 3, Issue 4 (12-2012)
Abstract
According to evidence-based medicine, randomized controlled clinical trials are a group of research designs which provides the highest level of clinical evidence, particularly regarding therapeutic or preventive interventions. Considering the dramatic increase in the number of published clinical trials in medical journals, the readership need to have knowledge about the problems that may occur during design and conduct of these studies, as well as about proper reporting of them. Due to importance of these studies in clinical medicine, several guidelines have been developed regarding designing, conducting and reporting clinical trials. One of the most important guidelines which has been developed to alleviate the problems in reporting randomized clinical trials is Consolidated Standards for Reporting Trials (CONSORT). In this article, some crucial points with regards to the report of the comparison of outcomes of interventions in randomized controlled trials will be reviewed briefly.
Hamideh Herizchi Qadim, Shahla Babaei Nejad, Badrolsadat Rahnama, Morteza Gojazadeh, Masood Sheykhnavasi,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Acne vulgaris is a common disorder of adolescence which may lead to significant cosmetic and psychological problems. Different topical and systemic therapeutic modalities have been used to treat acne vulgaris. This study was designed to compare the efficacy of topical 0.05% isotretinoin gel with 1% clindamycin solution in the treatment of acne vulgaris.
Methods: In this randomized clinical trial, 60 patients with mild to moderate papulopustular acne vulgaris were randomly allocated into two groups of equal sizes. One group was treated with 0.05% isotretinoin gel every night. The other group was treated with 1% clindamycin solution twice daily. Both groups were followed every month for 3 months.
Results: The mean of total lesion count decreased significantly after treatment in comparison with its mean before the treatment in both groups (P<0.001). The mean of acne severity index significantly reduced after treatment in both groups (P<0.001). Satisfaction of patients in clindamycin group was higher (P<0.001).
Conclusion: Decrease in total lesion count and acne severity index in both treatment groups were statistically significant however, considering the minimal complications and satisfaction of patients in clindamycin group, 1% solution of clindamycin may be recommended in the treatment of papulopustular of acne vulgaris.
Pouran Layegh, Zari Javidi, Parvin Layegh, Bita Kiafar, Saber Shojaei Nouri, Akram Momenzadeh,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Hirsutism is defined as male pattern hair growth in females which affects 10% of women. Our aim was to compare free salivary and free serum testosterone levels in women with hirsutism and healthy controls.
Methods: This study was a case-control study in which 30 hirsute women in child bearing age were recruited and compared with 10 healthy controls. For each patient, a questionnaire containing demographic, clinical and laboratory information was completed. The salivary and serum total and free testosterone plus free androgen index were measured by radioimmunoassay (RIA) method. The collected data were described and analyzed using SPSS software version 11.5. Significance level was determined at 0.05.
Results: No significant correlation was seen between salivary and serum free testosterone and in free androgen index with free testosteron in patients and control groups. Comparing the results between case and control groups, except for mean serum total testosterone level (P<0.05), the other results were not significantly different. No significant correlation was seen between hirsutism severity and free serum or salivary testosterone levels. Significant correlation was seen with total serum testosterone (P<0.001). Investigating correlations between these hormones with serum free androgen index, only salivary free testosterone was correlated with this index (r=0.01, P<0.05).
Conclusion: In our study, we find no correlation between free serum and salivary testosterone, so it seems that this evaluation method is not an appropriate alternative for serum evaluation of this hormone.
Akram Ansar, Maryam Tamimi, Leyla Mousavi, Sa'adat Torabiyan,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Skin basal cell carcinoma (BCC) is the most common cancer in human beings. Prevalence of this tumor has increased over the past decades. The standard treatment is complete excision, however some risks for recurrence still exist. The aim of this study was to determine the frequency of margin involvement in skin BCC as well as to investigate the demographic characteristics of the patients.
Methods: This study was conducted from April 2011 to April 2012 on the patients who had skin lesions suspected for BCC. The patients were undergone elliptical excision surgeries for removing their suspected lesions with 5-millimeter margins of clinically normal skin in Farchian Hospital, Hamadan, Iran. Following data were collected and recorded: age, sex, anatomical location, duration of the disease, primary clinical diagnosis, histopathologic type, and margin involvement.
Results: In total, 125 lesions from 115 patients were investigated (70 males, 45 females). The range of the ages of the patients were from 32 to 93 years, with a mean of 64.6 years. The most common histopathological type was nodular type (61.0%). Twenty percent of the excised lesions showed margin involvement. Risk factors for incomplete excision were older age and anatomical locations (ears and peri-ocular lesions). There was no statistically significant differences between sex, histological type, primary clinical diagnosis, and duration of the disease. In almost all cases, the clinical and histopathological diagnoses were similar.
Conclusion: To avoid repeated surgeries and to reduce the risk of incomplete excision for lesions on high risk locations, particularly in elderly, it is recommended that BCCs be excised with wide margins or Mohs micrographic surgery.
Nafiseh Esmaeili, Amirhooshang Ehsani, Mehdi Mohseni-Badalabadi, Kambiz Kamyab, Abbas Karimi,
Volume 3, Issue 4 (12-2012)
Abstract
Background an Aim: parapsoriasis is a rare chronic
idiopathic dermatosis which commonly manifests with round or oval scaling and
itching erythematosus plaques on trunk and extremities. Considering the size of
the lesions, parapsoriasis is divided into two groups: small plaque and large
plaque. Study of demographic characteristics of this disease may help to
identify the high risk groups who are more susceptible to cutaneous lymphoma
with high mortality as well as proper allocation of health service resources.
Methods: In this retrospective cross-sectional study,
affected parapsoriasis patients whom were referred to Razi Hospital in Tehran between
April 2003 to March 2009 were studied. Three hundred and twenty patients were
investigated for variables: age, sex, place of residence, location of the lesions
and clinical subgroups according to the histopathology reports.
Results: 53.4% of patients were female. The disease was most
commonly observed in age group of 20 to 50 years and the mean age of the patients
was 43.3 years. Eighty-five percent of the patients were inhabitant of Tehran
province. 88.1% of patients had large plaque lesions and 11.9% had small plaque
lesions. The most common sites of lesions were on the trunk (53.4%) followed
by the extremities (38.7%).
Conclusion: Based on these findings, it was determined that
parapsoriasis most commonly affects middle-aged women. Involvement of trunks and
extremities were most commonly observed. Large plaque type was the most common
type.
Mahmoud Farshchian, Akram Ansar, Mohammad Reza Sobhan, Saadat Torabian,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Psoriasis is a common chronic inflammatory skin disease. The risk factors of metabolic syndrome have been reported with greater frequency in patients with psoriasis. In this study, we aimed to evaluate these risk factors and compare them with normal population, as the control group.
Methods: In this case-control study, 55 patients with psoriasis were studied from 2011 to 2012 and 55 matched (for sex and age) persons were considered as control group. Age, gender, body mass index, systolic and diastolic blood pressures, smoking, alcohol consumption, type of disease, and blood levels of triglyceride, total cholesterol, LDL, HDL, and fasting sugar were evaluated in both case and control groups and compared.
Results: Our findings showed that levels of TG (P=0.005,OR: 1.02, 95%CI: 1.0-1.34) and LDL (P=0.03, OR: 1.04, 95%CI: 1.0-1.09), the frequency of smoking (P=0.02, OR: 2.2, 95%CI: 1.1-3.2), and the mean of systolic blood pressure (P=0.004, OR: 1.07, 95%CI: 1.02-1.33) were significantly higher in psoriatic patients, compare with control group.
Conclusion: Higher frequency of hypertension and lipid abnormalities in psoriatic patients may enhance the risk of cardiovascular diseases in them. Therefore, we recommend to check all patients with psoriasis, regardless of their disease severity, for serum lipid profiles and blood pressure. In addition, we strongly recommend giving up smoking, as a part of psoriasis treatment.
Alireza Firooz, Ali Rajabi Estarabadi, Hamed Zartab, Pegah Khoshpouri, Parisa Khoshpouri, Kambiz Kamyab,
Volume 4, Issue 1 (3-2013)
Abstract
Great progress in optics, electronic engineering, and computer science provide an opportunity to diagnosis of skin diseases, estimating effectiveness of drugs and skin care products using non-invasive, non-destructive methods of analysis. Also many noninvasive methods using analytic devices are developed to assessment of the outcomes of dermatologic surgeries on malignant skin tumors. The aim of this article is to review advanced methods for skin analysis on human’s skin such as magnetic resonance imaging and time domain reflectometry. Many kind of interesting applications are defined for using these methods especially in cosmetic pressures.
Mahnaz Banihashemi, Yalda Nahidi, Mohammmadjavad Yazdanpanah, Habib Allah - O - Esmaeeli, Somayyeh Khatibzadeh,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Pemphigus is one of the most common types of autoimmune blistering disease that requires systemic immunosuppressive therapy. Immunosuppressive therapy has improved the disease outcome in recent decades, but long-term use of them has side effects. Recently, it has been tried to evaluate immunosuppressive drugs with less side effects. One of them is mycophenolate mofetil. The aim of this study was to evaluate of therapeutic efficacy of this drug in the patients with refractory pemphigus vulgaris.
Methods: Three hundred files of patients with pemphigus vulgaris were reviewed and among them 28 patients who had received mycophenolate mofetil due to resistance to treatment were entered to this study. The data were obtained from patients’ files and were analyzed using Kendall's tau-c correlation, Mann-Whitney and ANOVA tests.
Results: Male to female ratio was 1.8:1 with an average age of 43.3±13.6 year. Twenty-eight cases of pemphigus vulgaris were treated receiving 2gr/day mycophenolate mofetil + 1mg/kg/day prednisolone. Remission occurred after 3 months. Seventeen patients (10 men and 7 women) had complete remission. There was no significant association between gender and treatment response (P=0.58). There was no significant association between mean age of treated patients and untreated patients with treatment response (P=0.77). Also, there was no significant association between severity of mucosal (P=0.80) and severity of skin involvement with treatment response (P=0.80). Ten patients who received mycophenolate mofetil more than 12 months had treatment response to mycophenolate mofetil and they did not have any relapse in the follow up period.
Conclusion: Mycophenolate mofetil is effective and safe as an adjuvant therapy in patients with pemphigus vulgaris especially in refractory pemphigus. Initiation of the therapeutic effect is slow.
Hamed Zartab, Feryal Faniyan, Zeynab Variji, Ali Rajabi Estarabadi, Alireza Firooz,
Volume 4, Issue 1 (3-2013)
Abstract
There are different ways to treat local obesity and cellulite including invasive and noninvasive methods. Due to the fact that noninvasive methods have significantly lower rates of adverse effects, they become more popular. One of these methods is acoustic wave therapy (AWT) or shock wave therapy (SWT). In addition to treating cellulite, SWT has been found useful for some other conditions. In this paper, we briefly introduce SWT and describe the protocol and results of treating cellulite and local obesity using Callactor® SC1 device (Storz Medical, Switzerland) in three females with normal body mass indices.
Soheil Rafiee, Fatemeh Mehravar, Golnaz Namazi, Mohammad Dehghan,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Cutaneous tuberculosis (TB) is a relatively uncommon form of extra pulmonary TB. Even in countries where TB still commonly occurs, cutaneous TB is rare. In our country accurate statistics of the forms of cutaneous tuberculosis are not available. The aim of this study was to assess the frequency of cutaneous tuberculosis during the years 1997 to 2012 in Gorgan, Iran.
Methods: In this retrospective cross-sectional study, patients affected with cutaneous tuberculosis referred to 5 Azar Hospital in Gorgan from April 1997 to September 2012 were studied. Data collected from the medical records of patients were statistically described and analyzed.
Results: In this study, 30 cases of cutaneous TB were found that 18 (60%) of them were women. The disease was most commonly observed in age group of 21 to 40 years. Lupus vulgaris (18, 60%), papulonecrotic tuberculid (6, 20%) and scrofuloderma (3, 10%) were the most common types of cutaneous tuberculosis in these patients.
Conclusion: Lupus vulgaris is the most frequent form of cutaneous tuberculosis in Gorgan.
Mojdeh Kiani, Fariba Mugouei,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: The change of the age pattern for using cosmetics in Iran is an important issue. The objective of this study was to evaluate factors affecting the cosmetics usage by the girls under 20 years old.
Methods: This survey was done in Yazdanshahr NajafAbad (Isfahan) using of measurement method and questionnaire instrument in the year 2011-2012. Three hundred indivisuals were randomly selected from 1800 female students in high school, secondary school and per-university levels.
Results: Most of the respondents named their close friends and relatives as their model of make up. 31.7% of the girls have set satellite channels as their model and 7.7% used internet sites. 44.3% of the girls agreed with the effect of relation with opposite gender on the amount of cosmetics usage. There is a meaningful relation between age, multimedia consumption, marriage status, social reliability and the tendency to the cosmetics usage.
Conclusion: The factors influencing the cosmetics usage include population characteristics, socio-economic base, multimedia consumption, relations, family and reliability which explain almost 55% of the changeability of the variances.
Majid Naderi, Hami Shamshiri, Shaban Alizadeh, Akbar Dorgalaleh, Rima Manafi, Shadi Tabibian,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Thalassemia is one of the most common single gene disorder that results from decrease or absence of globulin chain(s) synthesis. Repeated blood transfusion is required for prevention of severe anemia and related side effects, but it is associated with other complications such as cutaneous lesions and mucosal manifestations. This study conducted to assess the frequency of cutaneous and mucosal manifestations in patients with beta thalassemia.
Methods: This cross-sectional study was conducted on 300 patients with beta major thalassemia in Zahedan. Data were obtained from medical records and questionnaires as well as through physical examination of patients. The data were statistically described and tested.
Results: The mean age of patients was 17.9±6.3 years and 64.3% of patients were men and 35.7% were women. Among cutaneous lesions, freckles were the most common (70.7%) and the rarest one was peri orbital pigmentation (0.3%). Gingivitis (41.7%) and longitudinal lines on nails (72%) were the most common mucosal and nail manifestations.
Conclusion: Since cutaneous and mucosal manifestations are very common among patients with beta major thalassemia, regular dermatology follow up of these patients is recommended.
Masoud Golpour, Mehrdad Taghipour, Fariborz Azizi, Lotfollah Davoudi,
Volume 5, Issue 3 (10-2014)
Abstract
Psoriasis is a chronic inflammatory disease which may occur in childhood. In many psoriasis cases, the disease develops in individuals younger than 18 years old. Psoriasis in children presents with a variety of clinical manifestations. Becouse of its atypical presentations, early diagnosis of psoriasis is difficult in children. The plaque type psoriasis is the most common form of the disease in children. Different treatments such as phototherapy and systemic therapies have been proposed, but using any of them leads to serious complications in children. Therefore, early diagnosis and proper management of the disease are the main components of the treatment in pediatric psoriasis cases. Herein, we aimed to provide a general overview on the pediatric psoriasis, including its epidemiology, pathogenesis, clinical manifestations as well as the treatment and discussing the latest related information.
Rouhullah Dehghani, Rezvan Talaee, Fahimeh Chaharbaghi, Nahid Chaharbaghi, Marzieh Firouzi,
Volume 5, Issue 3 (10-2014)
Abstract
Paederus dermatitis is a common dermatitis in northern parts of Iran. Clinically, the most common presentation of paederus dermatitis is sudden onset of erythematous plaques with vesicles. The lesions usually affect exposed areas such as face, neck and arms. It is a common dermatitis between residents and tourists in northern provinces of Iran during spring and summer. Preventive measures include typical insect repellents precautions, such as using bed nets, long-sleeve clothing, and avoiding fluorescent lights. If the beetles are found on the skin, brushing them off, rather than crushing them, helps to prevent the dermatitis. Treatment includes washing the affected area immidiatley, applying cold and wet compresses, and in some cases, treatment with antibiotics, steroids, and antihistamines. Herein, we report a paederus dermatitis case in a 9-year old Kashani boy who had traveled to northern Iran as a tourist. We also review the related literature.
