Fatemeh Vandrajabpour, Reza Raoofian, Fatemeh Gholamali, Pedram Noormohammadpour, Morteza Hashemzadeh Chaleshtori, Mina Tabrizi,
Volume 4, Issue 4 (12-2013)
Abstract
Basal cell carcinoma (BCC) is the most common cancer in Iran and in the world and its prevalence may become equivalent to the prevalence of all other cancers combined in the future. The Hedgehog (Hh) signaling pathway has an important role in tumorigenesis of BCC. Mutations in PTCH and Smo molecules of this pathway account for 85% to 95% of sporadic BCCs and also most cases of inherited cases. Currently, several treatment methods exist for this cancer. Mohs surgery and removing the whole tumor with free margins are the most efficient way for metastatic and highly invasive BCCs. According to the latest findings, small inhibitor molecules of the Hh pathway are becoming highlighted in drug production. Vismodegib an inhibitor of Smo, was approved by the Food and Drug Administration in 2012 as a drug for metastatic and highly invasive BCCs. Therefore, strategic targeting of signaling molecules has demonstrated success and holds great potential in medicine.
Simin Shamsi Meymandi, Vaseli Mohammad Bagher, Farzad Abroud,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Common wart is a viral infection of epithelial tissues caused by human papiloma virus (HPV). In order to increase the efficacy and concurrent reduction of complications, different types of combination therapies have been recommended. One of them is the combination of cryotherapy with cantharidin. As cantharidin causes little pain and leaves small scars, we decided to design and conduct a randomized, controlled trial to investigate the efficacy of combined cryotherapy and topical cantharidin versus cryotherapy and a topical placebo. The mean number of the treatment sessions and complications of treatments were also compared between the two groups.
Methods: This study was a randomized, controlled double blind clinical trial in which 110 patients with verruca vulgaris were randomly allocated into two groups. After cryotherapy in both groups, topical lotion of cantharidin 0.7% (Canthacur) and flexible collodion as placebo were applied topically in the intervention and control groups, respectively. Patients were followed for healing rates, complications and recurrence of the lesions.
Results: The healing rates of lesions in both groups were 100%. The mean number of treatment sessions in the intervention and control groups were 3.4 and 4.7, respectively
(P<0.001). The incidence of hyperpigmentation in the intervention and control group were 29.1% and 10.9%, respectively (P=0.017). Atrophic scars in the case group were less common than the control group (9.1% versus 29.1%). Within 4 weeks of follow up after completion of the treatment protocol, the frequency of other complications and recurrence of the lesions showed no statistically significant difference between the two groups.
Conclusions: Combination of cryotherapy and cantharidin reduced the number of treatment sessions and atrophic scars, but increased the hyperpigmentation. Also, this combination therapy was ineffective in reducing other complications and the recurrence rate of the lesions.
Pedram Noormohammadpour, Amirhooshang Ehsani, Mostafa Mirshams Shashahani, Fatemeh Shahmohammadi, Fatemeh Gholamali,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Malignant melanoma is one of the most lethal skin tumors. Its prevalence and demographic specifications are different in European and western countries from those in the Middle East. This study was aimed to evaluate the demographic and clinical characteristics of malignant melanoma in Iran.
Methods: In this cross-sectional study, the patients with the diagnosis of malignant melanoma who atteneded the tumor clinic of Razi Hospital, Tehran, Iran were included. Demographic and clinical data were registered in specific questionnaires. Histopathology findings were also recorded in the questionnaires.
Results: A total of 2500 patients attending tumor clinic of Razi Hospital were evaluated. Out of them, 166 cases had malignant melanoma including 89 (53.6%) females and 77 males (46.4%). The mean age of patients 60.5 years. History of chronic sun exposure was found in 65 (39.2%) cases. Mean delay time between commencement of lesion and diagnosis was 9 months. The most common histopathologic type was acral lentiginous and the most common observed stage of tumor was Clark 3. The most common frequent observed tumor site was head and neck which was followed by limbs.
Conclusion: Malignant melanoma is common in patients with skin tumors in Iran. Considering morbidity and mortality of malignant melanoma and the relatively high stages of tumors, at the fist time the patients sought medical care, screening programs seems to be necessary to find the patients in earlier stages, as well as the mass education. Some of our findings such as the most common location of the tumors, family history and relation with dysplastic naevies, remain to be confirmed in studies with larger sample sizes.
Ali Ebrahimi, Hossein Ershadinia,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Unwanted hair growth (hirsutism) is a cosmetic problem, which has been resulted in a large number of researches regarding its treatment. Patient satisfaction after treatment using hair removal lasers has been different. The aim of this study was to investigate the satisfactaion rates of the patients with hirsutism after being treated with a diode laser.
Methods: In this study satisfaction rates of 50 women with hirsutism were evaluated based on an audio-visual evaluation in Haj Daii clinic in Kermanshah, Iran.
Results: Fifty patients with a maen±standard deviation age of 32.5±9.2 years were categorized in three groups in accordance with their skin phototypes. Patient satisfaction after using laser diode hair removal with 25-40 J/cm2 was 74.6%. The most common side effect was transient post laser erythema (28.3%). The highest satisfaction rate was obtained in patients who were taking hormone regulating drugs (85.0%). The lowest satisfaction was obtained in patients with irregular menstrual cycle who were not taking any hormon drugs (73.3%). There was a direct correlation between the number of laser sessions and patients satisfaction (r=0.51, P<0.05).
Conclusion: Findings of the present study showed that diode laser is an effective method in treatment of hirsute patients and patients satisfaction rates are good.
Azra Mohammadpanah Ardakan, Jalil Babapour Kheir-Ol-Din, Rahim Yousefi,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: The present research aimed to evaluate the psychometric properties of the Persian version of socio-cultural attitudes towards appearance questionnaire-3 (SATAQ-3).
Methods: The sample of this study cross-sectional was 250 highschool students (173 girls and 77 boys) in Abarkouh, who were selected through cluster random sampling, responded to Persian version of socio-cultural attitudes towards appearance questionnaire-3. The reliability coefficients of the SATAQ-3 were calculated using internal consistency and spilt-half methods, which were 0.77 and 0.55 respectively. The construct validity of the inventory was investigated using factor analysis.
Results: Factor analysis of the inventory using varimax rotation based on scree test, showed 4 factors labeled Internalization-General, Internalization-Athlete, Information and Pressures, which covered 37.61% percent of the total variance.
Conclusion: In general, findings of the research confirmed appropriate validity and reliability of the Persian version of SATAQ-3 and showed that it can be simply applied in clinical and research situations for evaluation of individual’s attitude towards personal appearance affected by socio-cultural factors.
Ameneh Yazdanfar, Mohammadreza Ahmadpanah, Zohre Kheradmand,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Vitiligo and acne are common chronic skin diseases with cosmetic impacts affecting various aspects of quality of life. This research was done to study the quality of life in these patients and their related factors.
Methods: This cross-sectinal study was carried out on 132 patients with vitiligo and 136 patients with acne. The patients were asked to answer questionnaires including questions about their demographic and clinical information as well as questionnaire of Dermatology Life Quality Index (DLQI). SpSS version 16 was used to statistically describe and test the data.
Results: The mean±standard deviation (SD) ages of patients with vitiligo and acne, were 22.8±5.7 and 28.9±11.5 years, respectively. The proportions of female patients with vitiligo and acne were 54.5% and 83.8%, respectively. Patients were matched for age and gender. There was no statically significant differrence between the mean DLQI score and age, martial status, occupation, residence, education, age of onset of disease in neither group. Patients with more chronic vitiligo experienced significantly impaired quality of life (P=0.008). A statistically differrence was found between mean DLQI scores and clinical forms of vitiligo. The mean scores of patients with generalized type was higher than those with localized forms (P=0.032). Patients with severe acne experienced significantly impaired quality of life (P=0.002). The mean DLQI scores in vitiligo and acne were 6.75 and 7.05, respectively, but this differrence was not statistically significant (P=0.08). A statistically significant difference was found in two subgroup: in symptoms and feelings (P=0.002) and interpersonal relationships (P=0.02).
Conclusion: The quality of lifves of patients were affecteded by the type of disease, its severity and its duration in both groups.
Mohammad Azad, Saman Ahmad Nasrollahi, Alireza Firooz,
Volume 5, Issue 1 (3-2014)
Abstract
Although ultraviolet rays constitute a small portion of the sunlight, they are destructive on skin. Ultraviolet rays cause sunburn, skin damage and skin cancers. Sunscreens are one of the most widely used cosmetic products which protect skin from cancer or other damages. There are two categories of sunscreen agents: chemical and physical. Physical sunscreens containing zinc oxide work through two mechanisms of reflection and scattering. Physical sunscreens are non-allergenic, non-irritating and non-comedogenic. Currently, by using zinc oxide nanoparticles in sunscreen formulation, both prevention of harmful sun rays and receiving cosmetic benefits are achieved.
Narges Alizadeh, Somaye Hoseinzadeh,
Volume 5, Issue 1 (3-2014)
Abstract
Osteoma cutis is a rare benign disease characterized by the presence of osseous nodules in the dermal layer of the skin. The cause of osseous depositions is unknown still. It may be primary or secondary. Herein, we reported a 55-year-old woman that presented with multiple skin color papules on her face.
Simin Shamsi Meymandi, Rezvan Amiri, Maryam Aflatunian, Abas Pardakhti,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: Androgenetic alopecia (AGA) is the most common type of alopecia in men. Currently, minoxidil is the only topical drug which has been approved by FDA for the treatment of AGA. However, its efficacy is restricted because of its low skin penetration. Since vesicular systems such as liposomes and niosomes have higher efficacy and lower adverse effects, this study was conducted to compare the efficacy of topical niosomal minoxidil with conventional minoxidil in the treatment of AGA.
Methods: This study was a randomized, controlled double-blind clinical trial. Ninety male patients with AGA according to Hamilton criteria were enrolled into this trial. The participants applied the interversion to which they were allocated twice a day, and were evaluated monthly for 6 months by a physician and patients self-assessments.
Results: Eighty-eight patients completed the trial. Mean increased hair count in niosomal minoxidil group and conventional minoxidil group in the last visit were 28.18±11.00 and 14.22±5.23, respectively (P<0.001). Moreover, evaluation of treatment response according to the patients self-assessments were 8.72±5.03 and 3.33±2.67 in niosomal and conventional minoxidil, respectively, which revealed more satisfaction in niosomal group (P=0.001). With the exception of two cases in niosomal minoxidil group whom were withdraw due to scalp itching and erthema no other adverse effect was observed in either group.
Conclusion: In the present study, application of topical niosomal minoxidil revealed an increase in the hair count in comparison with conventional minoxidil solution. Application of this new formulation for the treatment of AGA may be recommended.
Saman Ahmad Nasrollahi, Hurnaz Hassanzade, Taraneh Yazdanparast, Shadi Marami Zenouz, Mehdi Mohiti Asli, Alireza Firooz,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: Sunscreens are an important part of photoprotection strategy. They are exposed to strict safety evaluation using human subjects such as in vivo studies of skin irritation. Biophysical parameters measurements could be used as fast and noninvasive methods to measure any destructive effect of cosmetic formulations on skin application sites.
Methods: Five sunscreens were selected from Iran's market to determine changes in Transepidermal Water Loss (TEWL), stratum corneum hydration, pH, melanin and hemoglobin contents by biometric assessments with MPA 580Cutometer®.
Results: There was no significant change in skin pH, melanin and hemoglobin contents before and after sunscreen application. Significant change in TEWL and stratum corneum hydration after use of some sunscreens might be contributed by the occlusive and humectant ingredients which used in base cream.
Conclusion: Application of the studied sunscreens on human volunteers has not shown any adverse effects and these formulations could be recommended to use.
Hossein Mortazavi, Farid Abbasi, Maryam Koopaie, Nafise Esmaeili,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: Pemphigus vulgaris (PV) is the most common bullous autoimmune disease, which can cause mortality and morbidity in the patients who suffer from it. Researches to find reliable noninvasive laboratory tests to diagnose and monitor PV patients are being conducted.The aim of this study is to find the sensitivity of serum and salivary anti-DSG1 and anti-DSG3 antibodies in the diagnosis of PV by ELISA and to compare the results of serum and salivary autoantibodies with each other.
Methods: In this case-control study, 40 newly diagnosed patients with PV were recruited. Forty healthy controls were also recruited to this study. The clinical diagnosis of PV was confirmed by histopathology and direct immunofluorescence (DIF). Demographic data, disease severity and phenotypes were recorded on the questionnaires, which were developed for this study. DSG1 and DSG3 ELISA test were performed on serum and salivary samples of patients and controls.
Results: The mean±standard deviation age of patients, 43.37±11.94, with a range of 26 to 71 years. The sensitivities of serum anti-DSG3 and anti-DSG1 were 85% (34 cases had positive test results) and 90%, (36 cases had positive test results) respectively. The sensitivities of salivary anti-DSG3 and anti-DSG1 antibodies were accordingly 42.5% (17 cases had positive test results) and 60%, (24 cases had positive test results) respectively.
Conclusion: While the sensitivities of serum ELISA in detection of anti-DSG1 and anti-DSG3 were significantly higher than those of salivary ELISA, since the levels of the latter are chnaging in parallel to those of serum ELISA, they might be used to monitor the disease activity.
Pedram Nourmohammadpour, Amir Houshang Ehsani, Kambiz Kamyab, Bita Saghi, Hassan Seirafi, Ali Sadeghinia, Fatemeh Gholamali,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: Due to new popularity of cosmetic tattoos especially among women and its potential relationship with sarcoidosis, the present study was conducted to evaluate clinical presentation and some demographic data about tattoo granuloma, as part of non-infectious dermatologic granulomas.
Methods: In this retrospective cross-sectional study, all patients with the histopathological diagnosis of non-infectious granulomatous lesions whom were admitted between at the dermatology clinics at Razi Hospital, Tehran, Iran between March 21, 2007 and March 20, 2012 were included.
Results: A total of 1099 patients were included in the study. The commonest form of granuloma was foreign body granuloma in 511 (46.4%) of the patients and was followed by tattoo granuloma in 102 (9.2%) of the patients. All patients with tattoo granuloma were females whose ages were from 40 to 60 years. The mean±standard deviation age of the patients was 43±8.57 years. Twenty-six (25%) of patients with tattoo granuloma showed sarcoidal pattern, and one case (1%) showed caseouse pattern, after histopathological evaluation of biopsy specimens. Majority of the lesions were papular (32.3%) followed by nodular (24.5%) lesions.
Conclusion: Tattoo granuloma is the second common form of non-infectious granulomas, and in one-quarter of cases has sarcoidal pattern. Considering this finding, it seems reasonable to evaluate these patients for sarcoidosis.
Athar Moein, Mehran Heydari Seraj,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: The World Federation for Medical Education developed standards for medical education and recommended medical schools to encourage their students to take active responsibility for their self-learning, and prepare them for lifelong learning. The purpose of this study was to compare the viewpoints of medical students about the effectiveness of their participation in two methods of teaching-learning process, group discussion versus lecture.
Methods: This cross-sectional study was performed between the years 2011-2013 during which 19 one-month courses of dermatology for medical students were presented. In each course, attended by 5-7 students, 16 sessions of dermatology theory classes were planned. The first four sessions were completely presented by medical tutors and the next 12 sessions involved active student participation, 6 presented as group discussions and 6 aslecture presentation. At the end of each course the students’ perspective were asked by using a questionnaire evaluating the effectiveness of each method.
Results: From 102 students that participated in this study the following results were attained: 94 students (92.15%) considered group discussion more efficient than conference presentation (2 students [1.96%]), 5 (4.9%) reported both methods were efficient and 1 student (0.98%) said that none of these two methods were useful. The reasons that students preferred group discussion were: studying the subject matters before class and mental readiness, active participation of all students, learning at a higher degree and better durability of the subject in mind, expression of key points by the medical teacher, restatement of subject matters and enthusiasm of the class in group discussion.
Conclusion: Group discussion is a valuable technique in teaching-learning process which requires active participation of all students, leading to deeper understanding of the subject matters, self-learning and more attention to key points, it also makes the class more lively.
Fatemeh Valipoori Goodarzi, Javad Hadadnia, Maryam Hashemiyan,
Volume 5, Issue 2 (7-2014)
Abstract
Background and Aim: Skin cancer is the most common type of cancer constitutes and 75% of all cancers in the world. Malignant melanoma is the most invasive and lethal form of skin cancer. The objective of this study was to evaluate infrared thermography in differentiation of benign and malignant skin lesions.
Methods: This study was conducted on 120 patients (60 female, 60 male) with a lesion suspicious for melanoma and identifying the type of lesion (benign or malignant) based on thermal model using Fuzzy C-Means (FCM) clustering. In this imaging method, the difference on temperature responses between the normal and abnormal tissue was compared and data obtained was compared with biopsy results.
Results: In 120 cases studied, 3 cases of skin cancer (2 male, 1 female) were found which all could be detected based on analysis of thermal images.
Conclusion: At present, new methods for the detection of skin cancer, especially non-invasive diagnostic tools, have been discovered in several laboratories. The method presented in this paper could be considered as a non-invasive and cost effective method for the detection of skin cancer.
Hamid Salehinia,
Volume 5, Issue 2 (7-2014)
Abstract
Skin cancer is the most common cancer in humans worldwide. It is also the most common cancer in Iran. To achieve primary prevention in skin cancers, avoidance of direct sun exposure is recommended. Sunscreen use is one of the methods to reduce sun exposure. However, while using sunscreens has increased recently, the incidence rate of skin cancers has also increased. One of the reasons for observing this paradox may be caused by counterfit sunscreen products, in particular in Iran. The author imagines that this letter may result in proper decision making among health policy makers to tackle this problem.
Tahereh Soori, Nafiseh Esmaeili, Mostafa Mirshams-Shahshahani, Mohammad Reza Poursadati, Abbas Karimi,
Volume 5, Issue 4 (1-2015)
Abstract
Background
and Aim: The standard treatment regimen for pemphigus is
adminitration of systemic corticosteroids and adjuvant agents. Previous studies
have shown that corticosteroid therapy may alter lipid profile and reduce the
atherogenic index in some disorders. This study was conducted to evaluate
the changes in lipid profile in pemphigus patients treated with oral
corticosteroids alone or in combination with adjuvants.
Methods:
In this retrospective corss-sectional study, medical records of 148 pemphigus
patients admitted in Razi Hospital in Tehran were reviewed for serum levels of
low-density lipoprotein (LDL), high-density lipoprotein (HDL), total
cholestrol, and triglyceride on the day of admission till 3 weeks after
initiation of the treatment.
Results:
Fifty-eight percent of patients were female and the mean age of the patients
was 47.1 years. 79.3% and 13.3% of patients had been treated with prednisolone
plus azathiorine or prednisolone alone, respectively. The remainig patients
were treated by administration of oral prednisolone and other adjuvants. Serum
levels of LDL, HDL, total cholestrol and triglyceride were significantly higher
3 weeks after initiation of treatment compared to baseline (P<0.05). With
the exception of the signifcantly higher level of triglycerides in women, there
was no statistically significant association between the levels of other serum
lipids at the end of 3 weeks treatment with gender, age, severity of the
disease, use of statins, and the treatment regimen (P>0.05).
Conclusion:
Although the level of different components of the lipid profile in Iranian
patients with pemphigus changed after receiving treatment for 3 weeks, it seems
that those changes were not associated with an increased atherogenic index of
pemphigus patients.
Alireza Khatami, Alireza Firooz, Fathieh Mortazavi, Ramin Homayouni Zand, Yahya Dowlati,
Volume 5, Issue 4 (1-2015)
Abstract
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Background and Aim: Board
certification in any specialty is associated with a better professional
reputation as well as some other advantagessuch as the opportunity of working
as an academician. Accuracy of any test in the assessment of its participant
performance is of paramount importance. One of the main factors regarding
test accuracy is its validity.The aim of this study was to investigate the
views of the Iranian Board of Dermatology Examination Committee (IBDEC)
Members onimproving its validity.
Methods: This study was a
cross sectional survey. In order to extract the items for development of the
instrument for the survey, unstructured individual interviews were conducted
with two members of the IBDEC, two faculty members who were not members of
the IBDEC, and two resident dermatologists. Afterperforming a content
analysis, writing the items, and making revisions in accordance with the
expert panel suggestions, the face and content validities of the developed
instrument were confirmed by the panel. The instrument was distributed among
the members of the IBDEC in September 2013. The collected data were entered
into a data set.
Results: Fifteen of 16
present members of the IBDEC answered and returned the instrument to the
distributer. Ten (%66.7) of participants were male. Mean (standard deviation
[SD]) of age and membership duration in IBDEC of the participants were 56.1
(7.8) and 9.6 (6.2) years, respectively. The most difficult and easiest items
for being agreed upon were: "Inclusion of key feature problems (KFP) in
the written examination may result in better assessment of the residents'
clinical decision making" and: "In the board examination, attitudes
of the residents towards ethical issues are assessed properly".Cronbach's
α was calculated for assessment of the internal consistency of the instrument
and was equaled to 0.76.
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Conclusion: While 53% of the IBDEC
members were disagree with that the written board examination can assess
residents' different levels of knowledgeproperly, the majority of them were
also disagree with the implementation of suggested approved methods for
improving the validity of the written board examination. Most of them were also
disagree with implementation of evaluation methods for improving oral
examination validity.
Hamidreza Ghasemi Basir, Mahmood Farshchian, Pedram Alirezaei, Mahdis Jahani,
Volume 5, Issue 4 (1-2015)
Abstract
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Background and Aim: Cicatricial
alopecia is the result of irreversible substitution of hair follicles with
fibrotic tissue and presents as permanent loss of hair. Only a few studies
have investigated the clinical and histopathological characteristics of
cicatricial alopecia in Iran. The aim of this study was to determine the
demographic, clinical and histopathological characteristics of patients with
cicatricial alopecia who referred to our dermatology outpatient clinic in
Farshchian hospital in a two year period, and to evaluate the diagnostic
value of histopathologic criteria in diagnosing different kinds of
cicatricial alopecias.
Methods: This was a
cross-sectional study. Eighty nine patients who underwent skin biopsy due to
clinical diagnosis of cicatricial alopecia were included. Demographic and
clinical characteristics of patients as well as clinical diagnosis were
recorded and the biopsy samples were evaluated by two different pathologists
who were unaware of each other's diagnosis. Histopathological diagnosis of
patients according to each pathologist's opinion was recorded separately and
statistical analysis was performed to obtain the coincidence coefficient between
two pathological diagnosis.
Results: The most common
forms of cicatricial alopecias due to clinical and histopathological
diagnosis were: lichen planopilaris, disciod
lupus erythematosus, alopecia
areata, pseudopelade
of Brocq, folliculitis
decalvans and
central centrifugal cicatricial alopecia. Moreover,
our findings showed a powerful coincidence coefficient between clinical
diagnosis and the first pathologist diagnosis (kappa=0.836), an average to
powerful coincidence coefficient between the second pathologist diagnosis and
clinical diagnosis
(kappa=0.703) and finally an average to powerful coincidence coefficient
between the two pathologists diagnosis
(kappa=0.663).
Conclusion: Diagnosis of
cicatricial alopecia depends upon clinical and also histopathological
examination. Diagnostic value of histopathological criteria even at the end
of scarring process when there is considerable overlap between microscopic
findings of different etiologies of cicatricial alopecias is still acceptable
and there is no need to re-evaluate the biopsy specimen by a second
pathologist in order to confirm the diagnosis.
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Maryam Mirzaei, Saeid Razi, Mahshid Ghoncheh, Abdollah Mohammadian Hafshejani, Hamid Salehiniya,
Volume 5, Issue 4 (1-2015)
Abstract
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Background and Aim: Skin
cancer is the most common cancer in the world, which is associated with
mortality, mortality and health care costs. Planning prevention and control
of this cancer, information about its incidence rates and incidence trends is
necessary. The present study aimed to determine the incidence rates and
trends of skin cancer in Tehran.
Methods: In this
cross-sectional study, necessary data were extracted from the Cancer
Registry, Ministry of Health and Medical Education between 2003 and 2008. Age
- and sex -standardized incidence rates were calculated and the incidence
rate trends were determined.
Results: Between 2003 and
2008, 7429 skin cancer cases were recorded, of which 4807 were men and 2622
were women. Skin cancer incidence had an increasing trend in Tehran and its
incidence rate has increased from 8.99 in women and 11.52 in men in 2003 to
18.03 in women and 28.16 in men in 2008, respectively. In addition, incidence
of skin cancer was increased with aging in both men and women. The incidence
rate was higher in men than women.
Conclusion: Skin cancer
incidence in Tehran is increasing, which could be due to population aging,
environmental risk factors, and changes in life style. More comprehensive
research is suggested to investigate the risk factors for this cancer in
Tehran.
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Nafiseh Esmaeili, Sedigheh Talebi, Kambiz Kamyab, Abbas Karimi,
Volume 5, Issue 4 (1-2015)
Abstract
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Background
and Aim: Bullous pemphigoid (BP) is an acquired autoimmune
disease with subepidermal blisters commonly seen in the elderly over 60 years.
Although the disease is usually manifested with tense blisters, but in some
cases generalized pruritus is the only symptom of disease, which is less
studied.
Methods: In
a retrospective study, the medical records of 416 BP patients confirmed in pathology
laboratory were evaluated for clinical findings, direct immunofluorescence
(DIF) testing for BMZ-binding IgG antibodies and histological findings.
Results: Of
the 416 confirmed BP patients, 213 were male and 203 were female. The mean
age of patients was 64.36 years. Thirty four patients at the onset of the
disease had generalized pruritus, which in the course of the disease, 29
patients also showed other symptoms of the disease. In 5 patients generalized
pruritus was seen as the only symptom. Concerning to the results of DIF, 117
(90%) patients showed autoantibody deposit, and in 13 (10%) patients the test
was negative. There was no significant relationship between DIF results and
histological findings (p> 0.05).
Conclusion: According to the findings of
this study, generalized pruritus is uncommon as the first symptom of the
disease. There was not any association between generalized pruritus and
histological observations including dermal edema, presence of eosinophils in
tissue, subepidermal blister as well as DIF results. Further studies on the
early detection of the disease are required to decrease complications of the
disease.
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