Showing 74 results for Firooz
Zahrabeigom Moosavi, Alireza Firooz, Mahsa Fattahi,
Volume 12, Issue 4 (Volume 12, No 4 2022)
Abstract
Introduction: Tinea incognito is a localized skin infection caused by a fungus. Due to the use of corticosteroids, the shape and severity of the lesion are different from the usual skin manifestations by dermatophytes.
Background and Aim: A 39-year-old female with history of erythematous, scaly skin lesions on her hands, buttock, inguinal and both legs for 7 months referred to clinician, who prescribed Calamine-D and hydrocortisone without any treatment and clobetazole was recomended. She self-continued clobetazole. This case highlight the importance of mycological test in case of atypical skin lesions to choose an appropriate treatment and avoiding to spread of drug resistance species.
Methods: Regarding to history of patient, the mycological test (Direct Microscopy and culture) was made. In direct microscopy and culture mycelia of dermatophyte species was seen.
Results: In our case steroid discontinued and she was treated with oral terbinafine 250 mg once a day for 4 weeks in combination with topical clotrimazole cream.
Conclusion: the prescription of topical/oral corticosteroids should still be limited and take a caution until confirmation of diagnosis, particularly since the use of steroids during COVID 19.
Azin Ayatollahi, Taraneh Yazdanparast, Saman Ahmadnasrollahi, Mahsa Fattahi, Mahdieh Emambakhsh, Alireza Firooz,
Volume 13, Issue 1 (Volume 13, No 1 2022)
Abstract
Background and Aim: Hair loss is one of the most common problems among the skin and hair related diseases. Hair loss can lead to anxiety, depression, low self-esteem and dissatisfaction with appearance.
Methods: Patients with androgenetic alopecia who met the eligibility criteria entered the study. Participants were asked to randomly apply a solution of valproic acid 8.3% or a solution of minoxidil 5% on the affected areas according to the treatment protocol (twice a day). Before and 2 months after treatment, the participants were evaluated. The studied indices included the number of hair follicles in the specified area, the number of velus hairs, the number of terminal hairs, the average hair thickness, and the percentage of hairs in the anagen and telogen phases, as well as the skin reactions in the area. Hairs were examined at the beginning of the study and at 2 months after treatment using Foto Finder-trichoscale device.
Results: Two months after treatment compared to baseline in the valproic group, anagen hair count index (P=0.02), general hair count index (P=0.03), and terminl hair count index (P=0.012) showed significant changes. While telogen hair count (P=0.059) and vellus hair count (P=0.097) did not show significant changes. These changes were more significated in minoxidil group.
Conclusion: 8.3% valproic acid solution showed positive effects in increasing the number of hairs and decreasing the percentage of telogen hairs. Due to the delayed mechanism of valproic acid, the duration of treatment with this compound should be considered longer than minoxidil as a positive control.
Seyedebrahim Eskandari, Ali Khamesipour, Alireza Firooz, Minoo Tasbihi, Akram Miraminmohammadi, Khadijeh Tavakoli, Maryam Ahmadi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background and Aim: Leishmaniasis is a parasitic disease transmitted by sandflies and is one of the endemic diseases of Iran. With the spread of the Covid-19 epidemic worldwide, the virus will interface with endemic infectious diseases in different regions. In this study, coronavirus disease was evaluated in patients with a history of leishmaniasis referred to the Center of Research and Training in Skin Diseases and Leprosy.
Methods: A total of 91 patients with a history of leishmaniasis were studied for possible SARS-CoV-2 infection. The number of patients referred to the Center of Research and Training in Skin Diseases and Leprosy during the coronavirus epidemic was also compared with the same period before the epidemic
Results: A total of 60% of patients with leishmaniasis
did not report coronavirus disease. Twenty-one percent of cases had a mild corona disease, 13% had a moderate and 3% had severe corona disease. Only a single death was reported in corona patients with a history of cutaneous leishmaniasis. The number of referrals before the beginning of the corona epidemic was twice as high as during the epidemic.
Conclusion: In these participants, mortality and side effects of COVID-19 were significantly less reported. However, further studies are needed to evaluate the immune system and cutaneous leishmaniasis protection against COVID-19. Various factors can be effective in reducing patients during the epidemic, including not going to medical centers, reducing the number of trips, and observance of health issues.
Alireza Firooz, Azin Ayatollahi, Farnaz Valizade, Mansour Nassiri Kashani, Zaghrabeigom Moosavi, Mahsa Fattahi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background: Tinea capitis is the term used for scalp infections caused by dermatophyte fungi. Tinea capitis is common in children and is less common in adults.
Case Report: The case was a 9-year-old girl with itchy patches of alopecia on the. The patient had a cat as a pet. On examination, the patch of hair loss was itchy and the hair shaft was broken and scales were mild. In the examination with Wood's lamp and direct microscopic examination, the ectothrix infection was deagnised. According to the dermatologist's opinion, a terbinafine 50 mg was prescribed daily. However, no significant improvement was observed despite 4 weeks of terbinafine. As a result, the dose of terbinafine treatment was changed from 50 mg to 250 mg per day. After 6 weeks of treatment, the clinical manifestations of the patient improved significantly.
Conclusion: After ringworm is confirmed microscopically, choosing the most appropriate antifungal treatment depends on determining the fungal species by culture. Therefore, when choosing empiric antifungal agent therapy, a dose of 250 mg terbinafine may be a good choice for children.
Amirhoushang Ehsani, Arezou Jammanesh, Amirali Jahanshahi, Elnaz Khosravani, Reza Robati, Zahra Saffarian, Alireza Firooz, Vahide Lajevardi, Parvin Mansouri, Mansour Nassiri Kashani,
Volume 13, Issue 4 (Volume 13, No 4 2023)
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, internal medicine specialists, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.
Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2018. The current guideline is the result of scientific papers that got published from April 2018 to August 2022.
Hasti Ahmadian Yazdi Ahmadian Yazdi, Alireza Firooz, Maryam Movafegh, Faegheh Kazemi, Saman Ahmadnasrollahi, Aniseh Samadi,
Volume 13, Issue 4 (Volume 13, No 4 2023)
Abstract
Background and Aim: Oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumers. The purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration and roughness.
Methods: It was a 12-week, before-after clinical study, conducted on 20 participants (18 women and two men) aged 44.15±5.36 years with skin type III-IV. Skin elasticity parameters (R0, R2, R5 and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as four weeks after stopping its use (week 16). Participants’ satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.
Results: A significant improvement was detected in R2, R5 and skin friction at week 12 (P<0.041, P<0.012 and P<0.01, respectively). At week 16, the values remained at an increased level, which indicates the stability of the results. The increase of dermis density in week 16 was also significant (P=0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.
Conclusion: The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.
Minoo Tasbihi, Akram Miraminmohammadi, Ali Khamesipour, Seyedebrahim Eskandari, Alireza Firooz, Saman Ahmadnasrollahi,
Volume 14, Issue 2 (Volume 14, No 2 2023)
Abstract
Background and Aim: Cutaneous leishmaniasis is one of the most important health problems in Iran. There is still no effective vaccine available against human leishmaniasis and current treatment is based on chemotherapy. Conventional drugs are toxic and expensive, and drug resistance has caused the search for new treatments. Tofacitinib is a Janus kinase inhibitor that disturbs the signaling pathway of several cytokines in the immune system. The aim of this study was to evalute the effect of topical tofacitinib 2% ointment in healing cutaneous leishmaniasis in Balb/C mice.
Methods: This experimental study was performed using tofacitinib and glucantim drugs in 40 female Balb/C mice. The metacyclic form of promastigote of Leishmania major standard strain (MRHO/IR/75/ER) was injected into the footpad of the mice, the mice were divided into 4 treatment groups: tofacitinib, glucantim, tofacitinib-glucantim and control without treatment. The treatment period was 28 days. The footpad thickness of all groups was measured at the end of each week.
Results: After the end of the treatment in the groups treated with tofacitinib, a significant decrease in the size of lesion and the footpad thickness was observed compared to the control group without treatment (P<0.01).
Conclusion: It seems that tofacitinib ointment accelerates lesion healing in Balb/C mice and has worked similarly to standard glucantim treatment. Ointment can be a better option for leishmaniasis treatment and due to its ease of use and no need for painful injections it can be considered as an option for the treatment of patients with cutaneous leishmaniasis.
Hasti Ahmadian Yazdi, Alireza Firooz, Mohsen Rezaeian Vaghar, Elahe Kashani, Aniseh Samadi,
Volume 14, Issue 2 (Volume 14, No 2 2023)
Abstract
Background and Aim: In order to overcome the local side effects of the conventional treatments for atopic dermatitis, a new attitude regarding alternative treatments would be needed, which herbal medicines are promising approachs in this case.
Methods: It was a 4-week, before-after clinical study, conducted on 20 participants (16 women and 4 men) aged 39.95±11.04 years. The severity scoring of atopic dermatitis was determined based on total & local SCORAD. skin biophisical parameters including TEWL ,skin hydration, pH, temperature, sebum and skin erythema were also measured after 2 and 4 weeks application of the study product. Participants’ satisfaction as well as tolerability of the product were assessed by monitoring the adverse effects.
Results: A significant improvement was detected in LOCAL and TOTAL SCORAD at weeks 2 and 4 (P<0.01). The intensity of burning and pruritus also showed a significant decrease at weeks 2 and 4 (P<0.01). A significant increase in the skin hydration was shown at weeks 2 and 4 after treatment (P<0.01). 84.1% and 78.9% of participants described their skin lesions as "improved" or "much improved", 2 and 4 weeks after treatment respectively.
Conclusion: The test cream containing oats and chamomile extract is considered a safe and effective product for improving mild to moderate lesions of atopic dermatitis.
Taraneh Yazdanparast, Mansour Nassiri Kashani, Mansour Shamsipour, Fariba Izadi Heidari, Fateme Amiri, Alireza Firooz,
Volume 14, Issue 2 (Volume 14, No 2 2023)
Abstract
Background and Aim: Allergic contact dermatitis is the most frequent cause of eyelid dermatitis; but it is often misdiagnosed. This study aims to evaluate the characteristics of patients with eyelid dermatitis who referred for patch test.
Methods: This was a retrospective study. Three major subgroups were made: patients with only eyelid involvement, involvement of eyelids and other areas, and without eyelid involvement. Collected data included past history, diagnoses, personal care product & make-up use, occupational dermatitis, and positive allergens. Chi-squared, independent t-test, and one-way ANOVA were used for analysis.
Results: 139 patients with eyelid dermatitis who referred for patch test were included in the study. Allergic contact dermatitis was the most common diagnosis in all three groups referred for patch test. Use of shaving cream and hair conditioner was significantly higher in patients with only eyelid involvement and nickel sulphate was the most common allergen among them.
Conclusion: Patch testing is an important tool in the evaluation of the common dermatologic disease of eyelid contact dermatitis, as the gold standard. It is a necessity in the treatment of eyelid dermatitis, because of accurate identification of responsible allergens.
Aniseh Samadi, Mansour Nassiri Kashani, Azin Ayatollahi, Zahrabeigom Moosavi, Hasti Ahmdian Yazdi, Alireza Firooz,
Volume 14, Issue 4 (Volume 14, No 4 2024)
Abstract
Background and Aim: Recently, many Iranian companies have started manufacturing hyaluronic acid based dermal fillers. Current review aimed to assess and compare the clinical safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers.
Methods: The first part of the study reported, the overall safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers for improvement of nasolabial folds in 150 participants (age 44.30±9.97 years) using clinical and objectives assessment methods. In the second part, we performed a comparative study among 5 tested dermal fillers.
Results: Generally, at weeks 2, 12, and 24, 80.6%, 63.3%, and 60.66% of the participants, showed one grade or more improvement in the severity of nasolabial folds respectively. In all visits, the nasolabial folds biophysical parameters as well as the echo density dermis improved significantly compared to baseline. In comparative study, two fillers with the hyaluronic acid concentration of 24 mg/ml, showed the best objective efficacy, while in clinical evaluations, the filler containing mannitol has the best performance in reducing the severity of nasolabial folds showed.
Conclusion: Iranian hyaluronic acid based dermal fillers showed different levels of safety and efficacy for improvement of moderate to severe nasolabial folds, with efficacy.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (Volume 15, No3 2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
Homa Hatefi Minaei, Ali Khamesipour, Alireza Firooz, Akram Miraminmohammadi, Seyedebrahim Eskandari, Shahla Mirazizi, Minoo Tasbihi,
Volume 15, Issue 4 (Volume 15, No 4 2025)
Abstract
Background and Aim: Leishmaniasis is difficult to control and is not cost-effective in endemic areas. Antimony toxic compounds is the drug of choice, which drug resistance is increasing. Animal studies showed that interferon-gamma deficiency impairs the recovery of leishmaniasis. In this study, the therapeutic effects of subcutaneous injection of recombinant gamma interferon on leishmaniasis lesions in Balb/ C mice were evaluated.
Methods: 40 Balb/ C mice were infected with Leishmania major. After developing lesions, the therapeutic effects of interferon gamma alone or in combination with glucantime were investigated. Also, the standard treatment of glucantime and the control group without treatment were evaluated for comparison.
Results: The treatment groups (glucantime, gamma interferon, and gamma interferon-glucantime) had a significant difference (P<0.01) in terms of reduction in the footpad thickness compared to the control group. There was no significant difference in the mortality rate in the groups receiving gamma interferon and the group receiving standard glucantime treatment.
Conclusion: It seems that gamma interferon was effective in treating cutaneous leishmaniasis lesions in Balb/c mice alone and in combination with standard treatment and can be considered as an alternative treatment.
Aref Nassiri Kashani, Tarane Yazdanparast, Fateme Amiri, Mansour Nassiri Kashani, Alireza Firooz, Mahdi Gheisari,
Volume 16, Issue 1 (Volume 16, No 1 2025)
Abstract
Background and aim: Macular amyloidosis (MA) is a form of primary localized cutaneous amyloidosis (PLCA), characterized by amyloid deposits in the papillary dermis. This study aimed to compare the biophysical properties of MA lesions with those of adjacent uninvolved skin.
Methods: We measured several parameters in active MA lesions of 22 patients, including stratum corneum (SC) hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, and R5), as well as epidermal and dermal thickness and echo-density using ultrasonography. Measurements from the lesions were compared with those from healthy skin adjacent to the lesions, serving as controls. Statistical analysis was performed using the paired t-test, with P-values less than 0.05 considered significant.
Results: Compared to adjacent normal skin, MA lesions demonstrated significantly lower SC hydration and surface friction, while TEWL, pH, erythema index, melanin content, and epidermal thickness were significantly increased. No significant differences were found in sebum levels, temperature, elasticity parameters, or dermal thickness and echo-density.
Conclusion: MA lesions exhibit distinct biophysical and ultrasonographic changes consistent with their histopathological features. These characteristic alterations may serve as useful, non-invasive markers for the early diagnosis of cutaneous macular amyloidosis.
Aniseh Samadi, Mansour Nassiri Kashani, Azin Ayatollahi, Hamed Zartab, Maryam Ahmadi, Alireza Firooz,
Volume 16, Issue 3 (Volume 16, No 3 2025)
Abstract
Background and aim: In recent years, increasing demand for aesthetic treatments in Iran and the need for high-quality domestic products have encouraged several companies to produce botulinum toxin type A. This study aimed to evaluate and compare the clinical efficacy and safety of three such Iranian products.
Methods: In the first part of the study, the overall efficacy of the botulinum toxin type A products for treating glabellar lines was assessed in 230 participants who received one of the three Iranian formulations (mean age 42.69 ± 9.21 years), and compared with 230 participants who received the standard treatment (Dysport®) (mean age 42.50±9.79 years). Outcomes were evaluated on day 30 post-injection. In the second part, the comparative efficacy of the three domestic products during the same period and their safety profile up to month four post-injection were assessed.
Results: A clinically meaningful response (at least a two-grade improvement in glabellar line severity) was achieved in 68.6% of recipients of the Iranian products, compared with 52.8% of Dysport recipients, demonstrating a statistically significant superiority in equivalence studies (P<0.01). Among the three domestic products, only product No. 2 showed a significantly higher proportion of participants achieving ≥2-grade improvement (assessed by an independent physician). The type and frequency of adverse events (except for headache) were comparable to the standard drug monograph.
Conclusion: The findings indicate acceptable efficacy and safety of Iran-made botulinum toxin type A products compared with the reference product. Except for limited differences, the efficacy and safety profiles of the three formulations were generally similar up to day 30 post-injection.
