Showing 29 results for Mohammadi
Farzaneh Zarrinkar, Ali Khamesipour, Akram Miraminmohammadi, Ebrahim Eskandari, Mahmoud Nateghi Rostami, Esmaeil Fallah,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Leishmanization (LZ) is an effective tool to prevent
cutaneous leishmaniasis. Standardization of Leishmania is
the main drawback of LZ. The aim of this study was to assess the effect of
various preservatives on the infectivity of Leishmania.Methods: L.major harvested
at different stages of growth logarithmic, early and late stationary phases
were frozen using various preservatives of saccharose, glycerol, trehalose,
glucose, sorbitol, and dimethyl sulfoxide (DMSO). The harvested parasites were
inoculated into BALB/c mice before and after freezing. The infectivity of the
parasites was checked. IFA test was used to assess the rate of metacyclic
parasite.
Results: The ratio of
live Leishmania in different growth stages and various
preservatives were 89.0% to 98.2%. The lesion development in groups of mice
which received Leishmania in sacarose + glycerol or DMSO was started from 3rd
week and at 5th week all the mice showed lesion. The group of mice
which were inoculated with early or late stationary phases in saccharose +
glucose, saccharose + glycerol, glycerol 15% or DMSO showed lesion from 4th
to 5th week and in 100% showed lesions at 8th week. The
rate of metacyclic parasites increases from log phase to early and late
stationary phases.
Conclusion: There was a
correlation between percent of live parasite and the rate of lesion development
in BALB/c mice. Saccharose 22.5% + Glyserol 22.5% were the most appropriate preservative to freeze L. major. IFA
test is used to detect metacyclic Leishmania. A correlation was seen between the rate of
lesion development in BALB/c mice and IFA positivity.
Pedram Noormohammadpour, Amirhooshang Ehsani, Mostafa Mirshams Shashahani, Fatemeh Shahmohammadi, Fatemeh Gholamali,
Volume 5, Issue 1 (Volume 5, Number 1 2014)
Abstract
Background and Aim: Malignant melanoma is one of the most lethal skin tumors. Its prevalence and demographic specifications are different in European and western countries from those in the Middle East. This study was aimed to evaluate the demographic and clinical characteristics of malignant melanoma in Iran.
Methods: In this cross-sectional study, the patients with the diagnosis of malignant melanoma who atteneded the tumor clinic of Razi Hospital, Tehran, Iran were included. Demographic and clinical data were registered in specific questionnaires. Histopathology findings were also recorded in the questionnaires.
Results: A total of 2500 patients attending tumor clinic of Razi Hospital were evaluated. Out of them, 166 cases had malignant melanoma including 89 (53.6%) females and 77 males (46.4%). The mean age of patients 60.5 years. History of chronic sun exposure was found in 65 (39.2%) cases. Mean delay time between commencement of lesion and diagnosis was 9 months. The most common histopathologic type was acral lentiginous and the most common observed stage of tumor was Clark 3. The most common frequent observed tumor site was head and neck which was followed by limbs.
Conclusion: Malignant melanoma is common in patients with skin tumors in Iran. Considering morbidity and mortality of malignant melanoma and the relatively high stages of tumors, at the fist time the patients sought medical care, screening programs seems to be necessary to find the patients in earlier stages, as well as the mass education. Some of our findings such as the most common location of the tumors, family history and relation with dysplastic naevies, remain to be confirmed in studies with larger sample sizes.
Maryam Mirzaei, Saeid Razi, Mahshid Ghoncheh, Abdollah Mohammadian Hafshejani, Hamid Salehiniya,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
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Background and Aim: Skin
cancer is the most common cancer in the world, which is associated with
mortality, mortality and health care costs. Planning prevention and control
of this cancer, information about its incidence rates and incidence trends is
necessary. The present study aimed to determine the incidence rates and
trends of skin cancer in Tehran.
Methods: In this
cross-sectional study, necessary data were extracted from the Cancer
Registry, Ministry of Health and Medical Education between 2003 and 2008. Age
- and sex -standardized incidence rates were calculated and the incidence
rate trends were determined.
Results: Between 2003 and
2008, 7429 skin cancer cases were recorded, of which 4807 were men and 2622
were women. Skin cancer incidence had an increasing trend in Tehran and its
incidence rate has increased from 8.99 in women and 11.52 in men in 2003 to
18.03 in women and 28.16 in men in 2008, respectively. In addition, incidence
of skin cancer was increased with aging in both men and women. The incidence
rate was higher in men than women.
Conclusion: Skin cancer
incidence in Tehran is increasing, which could be due to population aging,
environmental risk factors, and changes in life style. More comprehensive
research is suggested to investigate the risk factors for this cancer in
Tehran.
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Mohammad Saatchi, Hamid Salehinia, Salman Khazaei, Mahdi Mohammadian, Abdollah Mohammadian-Hafshejani,
Volume 6, Issue 2 (Volume 6, Number 2 2015)
Abstract
Background and Aim: The aim of this study was to investigate various aspects of the treatment in patients with cutaneous leishmaniasis in Iran in the first half of 2014.
Methods: This cross sectional study was conducted on the existing data of 3684 patients with cutaneous leishmaniasis, whom were registered at the Disease Management Center of the Iranian Ministry of Health in the first half of 2014. Version 11 of Stata was used for statistical analysis and the level of significance was considered equals to 0.05.
Results: Of 3684 patients entered into the study (%55.1) were male and the mean age of the patients was 27±18 years. More than 34% of patients were treated with intralesional injections of meglumine antimoniate (MA) and 25% of patients recieved systemic MA injections. There were statistically significant correlations between the size and number of the lesions and the chosen treatment regimen (P<0.001). Thirty-five percent of patients treated with systemic MA between 7 to 10 days and 43.3% of patients recieved intralesional MA injections for 5 to 8 weeks.
Conclusion: More than %99 of patients fully recovered without complication or treatment failure. It seems that Iranian patients suffered milder CL in comparison with some other coutries.
Saman Mohammadi, Payam Khazaeli, Simin Shamsi Meymandi, Mahin Aflatoonian, Maryam Khalili Meybodi, Niloofar Mehrolhasani, Azadeh Mohebi, Yuns Jahani,
Volume 7, Issue 2 (Volume 7, Number 2 2016)
Abstract
Background and Aim: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Retinoids are used as the first line therapy in acne. Systemic absorption and skin irritation including redness, pruritus and exfoliation are some of their side effects. In this study we compared the efficacy of isotretinoin 0.05% niosomal gel versus adapalen 0.1% gel in treatment of acne vulgaris.
Methods: In this randomized double blind clinical trial, 144 patients with mild to moderate acne vulgaris aged from 15 to 30 years were enrolled. The patients were randomly allocated into two groups of A, whom were treated with isotretinoin 0.05% niosomal gel and B whom were treated with adapalen 0.1% gel. The patients were evaluated for clinical reponse, decrease in the number of inflammatory and non-inflammatory lesions and side effects after 2, 4, 8, and 12 weeks of the initiation of treatment.
Results: At the end of the study the clinical responses of comedones and inflammatory lesions in isotretinoin 0.05% niosomal gel group were 68% and 79%, in comparison with 65% and 76% in the adapalen gel group, respectively. The differences were not statistically significant. At the end of the treatment period more decrease in number of inflammatory and non-inflammatory lesions were seen in group A patients (niosomal isotretinoin) than group B (adapalen 0.1% gel) (P<0.001). Also side effect of skin redness was found more in group B (P<0.001).
Conclusion: Isotretinoin 0.05% niosomal gel has less side effects and more efficacy in the treatment of mild to moderate acne vulgaris in comparison with adapalen 0.1% gel.
Mehraban Felahati, Zeinab Ghasemi, Safar Shamohammadi, Seyed Ebrahim Eskandari, Reza Amiri, Mahdieh Rahimi, Dastparvardeh Elmira, Shahabeddin Rahimifar,
Volume 7, Issue 3 (Volume 7, Number 3 2016)
Abstract
Background and Aim: Bacteria are one of the causes of nail infections. Although nail infections are not always associated with a major health problem, their treatment, particularly in immunosuppressed patients could be chalenging. This study was conducted to investigate the prevalence of bacterial agents in patients with dystrophic nails referred to mycology laboratory of Razi Hospital, Tehran.
Methods: This was a cross-sectional study on patients with dystrophic nail. Samples were examined by both direct examination and culture. Blood agar and eosin methylene blue (EMB) agar media were used to culture and differentiate bacteria.
Results: Of 700 dystrophic nail samples, 183 (26.1%) samples were diagnosed as onychomycosis. One hundred and four (56.8%) of the patients were female. One hundred and eighty-one patients had bacterial nail infection (25.9%), of whom 109 (60.2%) were female. Forty-six (6.6%) patients had both bacterial and fungul infections, of whom 32 (69.6%) were female. The most common detected agent was Staphylococci.
Conclusion: Bacterial infections can result in dystrophioc nails. If these infections remain untreated they can lead to nail loss. In most cases, treatment of bacterial nail infections is easier than fungul nail infections.
Yousof Fakour, Amir Houshang Ehsani, Saeedeh Mohammadi,
Volume 7, Issue 3 (Volume 7, Number 3 2016)
Abstract
Background and Aim: Psoriasis is a common chronic skin disease with high morbidity and economic burden for patients and healthcare system. The goal of this study was to evaluate the impact of age, disease severity, and therapeutic regimen on the quality of life of the patients with psoriasis who were treated with biological drugs.
Methods: This cross-sectional study was conducted on 110 patients suffering from psoriasis whom were admitted to the psoriasis clinic in Razi Hospital, Tehran, Iran in 2015 and 2016. The Persian version of the Dermatology Life Quality Index (DLQI) questionnaire was used to evaluate patients' quality of lives. Using IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) version 22, descriptive and inferential statistics methods were applied to summarize and present the collected data. Chi square test was used for making comparisons.
Results: Seventy-four male patients and 36 female patients were enrolled. The mean age of the participants was 38.8 (range: 18 to 73) years. DLQI scores had a normal distribution and a mean ± standard deviation (SD) equals to 6.51±6.66. The correlations between age and disease severity, quality of life and age, as well as quality of life and disease severity, and quality of life and treatment were not significant (P>0.05).
Conclusion: It seems that the quality of lives of the patients were not affected by the age, severity of the disease, and therapeutic regimen of biological drugs.
Fahime Nemati, Masome Mohammadzaki, Safar Shamohammadi, Zeinab Ghassemi, Ebrahim Eskandari,
Volume 8, Issue 1 (Volume 8, Number 1 2017)
Abstract
Background and Aim: Staphylococcus aureus is the second cause of hospital acquired infections, and responsible for 80% of purulent infections, and majority of skin infections. About 30 to 50 percent of normal people carry staph in their nose or groin and armpits. VanA, VanB, VanC1, VanC2/C3, VanG, VanL, and VanX are genes responsible for encoding resistance to vancomycin, TychoPlanyn and Avoparcyn, among them vanBand vanAare the most common cause of resistance that could be located on a plasmid or a chromosome and can be transferred via conjugation. The aim of this study was to The aim of this study was to investigatethe role of VanA and VanB genes in Cefoxitin resistant Staphylococci aureuscausing skin infections in patients admitted to Razi Hospital in Tehran using real time PCR method.
Methods: The samples were collected from Khordad 1394 for one year in the Microbiology Department of the Clinical Laboratory of Razi Hospital. Exudative skin lesions were sampled by sterile swab and cultured on the blood agar and EMB medium. Then catalase, oxidase and coagulase tests were performed on the gram-positive cocci and the sensitivity to vancomycinin Cefoxitin-resistant Staphylococcus aureus was determined using the E-test method. The presence of vanAand vanBgenes were investigated by Real Time PCR.
Results: Out of 978 patients with infected skin lesions, 733 samples of Staphylococcus aureus were isolated. Of these, 124 were Cefoxitin resistant, among them 8 samples had a high response rate of 3, and 5had high response above 16. But VanA and VanB genes were not responsible for resistance in any of them.
Conclusion: Due to the development of resistant strains of Staphylococcus in skin and hospital infections, identification of its encoding genes are necessary in order to use appropriate antibiotics to reduce the course of treatment and the side effects of taking antibiotics.
Masoud Mohammadi,
Volume 8, Issue 3 (Volume 8, Number 3 2017)
Abstract
Background and Aim: Alopecia is one of the most common chronic skin diseases and is one of the most important predictors of psychological distress and depression. Considering the importance of this issue to public health, this study evaluated the impact of alopecia on increasing depression in the affected population
Methods: A meta-analysis was performed for relevant articles in scientific databases including SID, Science direct and PubMed (Medline). Reference lists of identified articles were reviewed for additional articles. Heterogeneity of study was checked using I2 index. Data were analyzed using the Comprehensive Meta-analysis (CMA) software.
Results: The overall prevalence of depression in patients with alopecia in Iran was %60.3 (%95 Cl %51.4-%68.5) during 2001-2015. The highest prevalence of depression was recorded in Khorramabad in 2007, %66.7 (%95 Cl: %56.3-%75.6) and the lowest prevalence of depression was found in Mashhad in 2010, %47.3 (%95 Cl: %41.7-%53).
Conclusion: According to the results of this study, the prevalence of depression in patients with alopecia is high and therefore appropriate therapies and the need for psychological counseling for these patients seems to be necessary.
Hamid Kharatzadeh, Abolfazl Mohammadi, Fariba Jaffary, Sayed Mohsen Hoseini,
Volume 9, Issue 2 (2018, Volume 9, Number 2 2018)
Abstract
Background and Aim: Vitiligo is a prevalent depigmentaling skin disorder, which has a great impact on the quality of life of patients. The purpose of this study was to investigate the relationship of quality of life of these patients with self-compassion and experiential avoidance.
Methods: In this analytical cross-sectional study, Self-Compassion Scale (SCS), Second Edition of Acceptance and Action Questionnaire (AAQ-II), and Vitiligo Quality of Life Index (VitiQoL) were completed by 105 patients with vitiligo (49.5% male) who were selected through available sampling method. The data were analyzed using descriptive statistics, Pearson correlation coefficient, t-test, ANOVA and covariance analysis.
Results: The average of quality of life score of the participants in the study was 32.14. There was a significant relationship (P<0.01) of the quality of life scores with the scores of experiential avoidance (R=0.28), self-judgment (R=0.36), isolation (R=0.52) and extreme identification (R=0.42). After removing the confounding effect of the variables on each other, the relationship of quality of life score with the location of the lesion (P=0.04) and isolation score (P=0.001) was significant.
Conclusion: Self-compassion and experiential avoidance play an important role in the quality of life of patients with vitiligo, and targeting these two components through psychological treatments can be effective in improving the quality of life of these patients.
Parviz Molavi, Majid Rostami, Mehriar Nadermohammadi Moghadam, Atrin Khalkhali, Habibeh Salvat,
Volume 9, Issue 3 (2018, Volume 9, Number 3 2018)
Abstract
Background and Aim: Considering the high role of psychological factors in somatic disorders, especially in dermatologic disorders, the prevalence of personality disorders in psoriatic patients was studied.
Methods: Among patients referred to Dermatology Clinic of Imam Khomeini Hospital in Ardabil, 81 patients with psoriasis (case group) and 80 without skin disease (control group) were evaluated. The two groups were matched in terms of age and sex. The severity of psoriasis was determined based on the psoriasis area and severity index (PASI) index as mild, moderate and severe by the dermatologist. The traits and personality disorders were assessed and compared between two groups using MCMI-III questionnaire.
Results: There was a significant difference in depressive, dependent, obsessive and hystrionic personality traits or disorders between two groups. There was a reverse correlation between the severity were more common psoriasis and obsessive and dependent personality disorders, so they among mild and moderate psoriasis patients.
Conclusion: This study emphasized the role of psychological factors in course of psoriasis. Better strategies for prevention and treatment of psoriasis will be achieved by a careful examination of the behavioral, cognitive and emotional patterns of cluster C personality. It is also necessary to provide psychotherapy services to these patients along with drug therapy.
Samira Shirmohammadi, Saeedehsadat Hosseini, Hassan Amiri,
Volume 10, Issue 2 (2019, Volume 10, Number 2 2019)
Abstract
Background and Aim: Cosmetic surgery is one of the most common phenomena in recent decades. Due to high prevalence of psychiatric disorders among the cosmetic surgery applicants, it is important to explore the pathways and variables which affect mental health of these people. The aim of the present study was to investigate the mediating role of difficulties in excitement adjustment in the relationship between attachment styles and psychopathology in women undergoing cosmetic surgery.
Methods: The present study was descriptive and based on correlation models. The sample included all women who applied for cosmetic surgery who referred to the specialized surgical centers of Kermanshah, 300 of whom were selected by available sampling method. Data were collected by attachment styles. Excitement adjustment difficulty and psychopathology questionnaire and were analyzed by SPSS 22 and LISREL 8/8.
Results: The hypothesized model of research is fitted with the experimental data. There was a significant relationship between attachment styles and psychopathology directly and indirectly. The results of path analysis indicated mediating role of the difficulties of excitement adjustment in the relationship between attachment styles and psychopathology.
Conclusion: Attachment styles and difficulties in excitement adjustment can be effective in preventing, diagnosing and treating of mental disorders, and promoting mental health of cosmetic surgery applicants.
Ensieh Lotfali, Akram Miraminmohammadi, Mahshid Shahrzad, Ali Khamesipoor, Alireza Firooz, Azam Fattahi,
Volume 11, Issue 1 (Volume 11, No 1 2020)
Abstract
Background and Aim: The aim of the present study is rapid and precise identification of yeast species isolated from nail of patients with clinical features of onychomycosis using PCR-RFLP technique.
Methods: 50 patients with involvement of 29 fingernails and 21 toenails were enrolled in the study. Different yeast species were identified by conventional mycological. The PCR-RFLP was tested on yeast isolated and the PCR-RFLP products were separated by electrophoresis in 2% agarose gel, with DNA stain.
Results: The main causative agents were yeasts in 12 cases (24%). Candida albicans was the most commonly isolated yeast species followed by Candida parapsilosis (6%), and Candida glabrata (4 %).
Conclusion: PCR-RFLP method using ITS1-ITS4 primers and MspI restriction enzymes is a rapid, accurate and cost-effective method for specific diagnosis of the most prevalent candida spp. Its ability to detect low amounts of fungal DNA in patient samples in 6-8 hours could be useful for clinical laboratories for optimal management of these infections.
Samira Shirmohammadi, Saeedehsadat Hosseini, Hassan Amiri,
Volume 11, Issue 2 (Volume 11, No2 2020)
Abstract
Background and Aim: Cosmetic surgery is one of the most common phenomena in recent decades. Due to high prevalence of psychiatric disorders among cosmetic surgery applicants, it is important to explore the pathways and variables affecting their mental health. The aim of this study was to investigate the mediating role of basic psychological needs in the relationship between attachment styles and psychopathology in women undergoing cosmetic surgery.
Methods: The research was descriptive and based on correlation models. Available sampling method was employed in order to gather data from 300 women referring to Kermanshah specialized surgical centres, for doing cosmetic surgeries. Collected data were analyzed employing attachment styles questionnaire, basic psychological needs and psychopathology, and by SPSS 22 and LISREL 8/8.
Results: The hypothetical model of the research fitted the experimental data. There was a significant relationship between attachment styles and psychopathology directly and indirectly. The results of path analysis indicated a mediating role for the difficulties of psychological needs in the relationship between attachment styles and psychopathology.
Conclusion: Attachment styles and basic psychological needs can be effective in preventing, diagnosing and treating of mental disorders, and promoting mental health of cosmetic surgery applicants.
Farasat Noormohammadifar, Alireza Soltanian, Pedram Alirezaei,
Volume 11, Issue 3 (Volume 11, No 3 2020)
Abstract
Background and Aim: Trichoscopy is a non-invasive diagnostic tool for hair diseases. The aim of this study was to evaluate the trichoscopic findings in different types of alopecia.
Methods: This cross-sectional study was conducted on 155 alopecia patients referring to Hamadan’s Sina hospital from March 2019 to July 2020. The patients were recruited after giving written informed consent. Scalp biopsy was performed to confirm the diagnosis and trichoscopic evaluation was then carried out. Trichoscopic findings along with demographic data were recorded. Data was analyzed using SPSS 16.0 software and appropriate statistical methods.
Results: A total of 155 patients including 79 males and 76 females were included in the study. The most common trichoscopic finding in alopecia areata was vellus hair (95.5%). The most common finding in androgenetic alopecia (AGA) was hair shaft thickness heterogeneity which was observed in all AGA patients. The most common findings in telogen effluvium (TE) were single hair pilosebaceous units, peripilar sign, thin terminal hairs and upright regrowing hairs which were observed in all TE patients. The most common finding in lichen planopilaris was perifollicular scaling (81.8%). The most common findings in discoid lupus erythematosus were large yellow dots (100%) and fine scaling (100%). Black dot was the most prevalent finding in tinea capitis (85.7%).
Conclusion: Trichoscopy ,as a non-invasive tool, could be helpful in differentiating different types of alopecia.
Mohammadreza Sobhan, Faezeh Mohammadi, Elham Khanlarzadeh, Mohammad Faryadras,
Volume 12, Issue 1 (Volume 12, No 1 2021)
Abstract
Background and Aim: Warts are benign tumors caused by different types of human papillomavirus. Different methods are used in the treatment of warts. The aim of this study was to compare the effectiveness, side effects and number of treatment sessions of CO2 laser and cryotherapy in the treatment of plantar warts
Methods: Seventy patients (140 feet) with plantar warts on both feet who referred to the dermatology clinic of Farshchian (Sina) Hospital in Hamadan during 2019-2020 were selected by convenience sampling method. The warts were randomly treated with either CO2 laser or cryotherapy on each foot. After treatment, patients were evaluated every two weeks for up to five sessions for requirement of treatment repetitions and assessment the extent of healing. In the cases with
non-healing lesion, treatment was repeated once every two weeks for up to five sessions.
Results: The mean age of the patients was 22.11±8.73 years, and 35.7% were male and 64.3% were female. In the CO2 laser and cryotherapy groups, the frequency of recovery rate was 81.4% and 41.4%, (P<0.001), and the mean number of treatment sessions was 1.90±0.84 and 3.55±0.69 (P<0.001) respectively. Frequency and type of side effects in the CO2 laser and cryotrapy group was pain 25.7% and 94.3% (P<0.001), itching zero and 32.9% (P<0.001), blisters 2.9% and 82.9% (P<0.001) and hyperpigmentation with zero and 12.9% (P=0.003), respectively.
Conclusion: CO2 laser is more effective than cryotherapy in less number of sessions and with less side effects for the treatment of plantar warts
Afsarolmoluk Hadadian, Azin Ayatollahi, Akram Miraminmohammadi, Mahshid Shahrzadkavkani, Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi,
Volume 12, Issue 3 (Volume 12, No 3 2021)
Abstract
Introduction: Dermatophytosis are micro-organisms which can lead to skin diseases. In rare occasions they can have atypical skin manifestations, which could result in delay in diagnosis.
Case Report: A 20-year-old Iranian boy was referred to our center with a 5-month history of circular, symmetrical, itchy crusted skin lesions on his groin. Direct microscopy, culture test and PCR-sequencing of ITS regions of the rDNA gene were conducted and showed T. indotinea as the causative agent. Based on antifungal susceptibility test oral pulse therapy with itraconazole 100 mg twice daily for 1 week combined with topical clotrimazole cream for 1 month was initiated, which cleared the lesions.
Conclusion: This case report is of significance since T. indotinea produces atypical skin lesions, as well as, multidrug resistance to antifungal agents.
Akram Miraminmohammadi, Minoo Tasbihi, Seyedebrahim Eskandari, Maryam Ahmadi,
Volume 12, Issue 4 (Volume 12, No 4 2022)
Abstract
Leishmaniasis is a neglected disease caused by different Leishmania species and transmitted by various sand flies. Iran is endemic to both visceral and cutaneous form of the diseases. The aim of this study was to investigate the epidemiological factors of leishmaniasis in patients referred to the Center for Research and Training Skin Disease and Leprosy from 1399-1400. The present study is a cross-sectional study in which every patient with suspected cutaneous leishmaniasis lesion(s) referred to the center during 1399-1400 were included. The results showed a higher number of patients with leishmaniasis are in the age group of 10 to 19 years. Among the mentioned jobs, a higher percentage was assigned to housewives in the affected women and workers in the affected men. According to the results, autumn is the most common season for cutaneous leishmaniasis. The average time from beginning to the diagnosis of leishmaniasis was 1.5-3 months and most patients showed a history of traveling to rural areas. The number of wet type lesions were higher than dry type and most of the lesions were in the hands. Most cases were reported from Isfahan province.
Seyedebrahim Eskandari, Ali Khamesipour, Alireza Firooz, Minoo Tasbihi, Akram Miraminmohammadi, Khadijeh Tavakoli, Maryam Ahmadi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background and Aim: Leishmaniasis is a parasitic disease transmitted by sandflies and is one of the endemic diseases of Iran. With the spread of the Covid-19 epidemic worldwide, the virus will interface with endemic infectious diseases in different regions. In this study, coronavirus disease was evaluated in patients with a history of leishmaniasis referred to the Center of Research and Training in Skin Diseases and Leprosy.
Methods: A total of 91 patients with a history of leishmaniasis were studied for possible SARS-CoV-2 infection. The number of patients referred to the Center of Research and Training in Skin Diseases and Leprosy during the coronavirus epidemic was also compared with the same period before the epidemic
Results: A total of 60% of patients with leishmaniasis
did not report coronavirus disease. Twenty-one percent of cases had a mild corona disease, 13% had a moderate and 3% had severe corona disease. Only a single death was reported in corona patients with a history of cutaneous leishmaniasis. The number of referrals before the beginning of the corona epidemic was twice as high as during the epidemic.
Conclusion: In these participants, mortality and side effects of COVID-19 were significantly less reported. However, further studies are needed to evaluate the immune system and cutaneous leishmaniasis protection against COVID-19. Various factors can be effective in reducing patients during the epidemic, including not going to medical centers, reducing the number of trips, and observance of health issues.
Minoo Tasbihi, Akram Miraminmohammadi, Ali Khamesipour, Seyedebrahim Eskandari, Alireza Firooz, Saman Ahmadnasrollahi,
Volume 14, Issue 2 (Volume 14, No 2 2023)
Abstract
Background and Aim: Cutaneous leishmaniasis is one of the most important health problems in Iran. There is still no effective vaccine available against human leishmaniasis and current treatment is based on chemotherapy. Conventional drugs are toxic and expensive, and drug resistance has caused the search for new treatments. Tofacitinib is a Janus kinase inhibitor that disturbs the signaling pathway of several cytokines in the immune system. The aim of this study was to evalute the effect of topical tofacitinib 2% ointment in healing cutaneous leishmaniasis in Balb/C mice.
Methods: This experimental study was performed using tofacitinib and glucantim drugs in 40 female Balb/C mice. The metacyclic form of promastigote of Leishmania major standard strain (MRHO/IR/75/ER) was injected into the footpad of the mice, the mice were divided into 4 treatment groups: tofacitinib, glucantim, tofacitinib-glucantim and control without treatment. The treatment period was 28 days. The footpad thickness of all groups was measured at the end of each week.
Results: After the end of the treatment in the groups treated with tofacitinib, a significant decrease in the size of lesion and the footpad thickness was observed compared to the control group without treatment (P<0.01).
Conclusion: It seems that tofacitinib ointment accelerates lesion healing in Balb/C mice and has worked similarly to standard glucantim treatment. Ointment can be a better option for leishmaniasis treatment and due to its ease of use and no need for painful injections it can be considered as an option for the treatment of patients with cutaneous leishmaniasis.
