Ilshan Lotfi, Seyedsaeed Tamehrizadeh, Mohammadhassan Javanbakht, Maryam Ghiasi, Mahshid-Ol-Sadat Ansari,
Volume 13, Issue 3 (11-2022)
Abstract
Background and Aim: Alopecia areata is an autoimmune disease of hair follicle. Osteopontin is an early T lymphocyte activator that may play a role in some immunological diseases. The aim of this study was to evaluate the serum level of osteopontin in patients with alopecia areata and compare it with the level in normal subjects.
Methods: 54 patients with alopecia areata who presented to the Razi Hospital in Tehran in 2017 and 2018 were enrolled. Half of the patients had severe disease and half of them had mild disease. Also, 52 healthy subjects were selected as control group (age and sex matched). The severity of disease was determined using SALT Score. Serum osteopontin levels were measured by ELISA method.
Results: The results showed that serum osteopontin levels were significantly higher in patients with alopecia areata than healthy subjects. There was no significant relationship between osteopontin level and SALT score or duration of the disease.
Conclusion: The level of osteopontin is higher in AA patients than normal subjects but it does not correlate with the severity of disease.
Majid Rostami Moghaddam, Hamed Zandian, Mohammad Jafarzadeh, Amirhossein Jodeiri Agaei,
Volume 15, Issue 3 (11-2024)
Abstract
Background and Aim: Telogen effluvium (TE) is a type of diffuse hair loss that occurs 2 to 3 months after a stressful event, including a covid-19 infection. The aim of this study was to determine the frequency of TE in women with covid-19.
Methods: This descriptive study was conducted on 270 women who referred to the skin and hair clinic of Imam Reza Ardabil Hospital with complaints of hair loss. Information related to the history of covid-19 infection, hospitalization, medications, vaccination and demographic characteristics were collected. The severity of alopecia was checked by clinical examination and traction test, and the data were analyzed with SPSS software.
Results: The average age of the patients was 41 years. 61.1% had a history of hospitalization, 43.7% used antibiotics, 61.8% used corticosteroids, and 51.8% used NSAID. The severity of Covid-19 had a significant relationship with the earlier occurrence of TE (P=0.001) and the increase in the number of pulled hairs in the traction test (P=0.001). Hospitalization due to covid-19 and corticosteroid use reduced the time between illness and onset of TE symptoms. The injection of AstraZeneca vaccine was associated with an increase in the number of plucked hairs (P=0.02).
Conclusion: The severity of TE was related to the severity of covid-19, hospitalization, corticosteroid use and injection of AstraZeneca vaccine.
