Showing 30 results for Mohammadi
Samira Shirmohammadi, Saeedehsadat Hosseini, Hassan Amiri,
Volume 10, Issue 2 (2019, Volume 10, Number 2 2019)
Abstract
Background and Aim: Cosmetic surgery is one of the most common phenomena in recent decades. Due to high prevalence of psychiatric disorders among the cosmetic surgery applicants, it is important to explore the pathways and variables which affect mental health of these people. The aim of the present study was to investigate the mediating role of difficulties in excitement adjustment in the relationship between attachment styles and psychopathology in women undergoing cosmetic surgery.
Methods: The present study was descriptive and based on correlation models. The sample included all women who applied for cosmetic surgery who referred to the specialized surgical centers of Kermanshah, 300 of whom were selected by available sampling method. Data were collected by attachment styles. Excitement adjustment difficulty and psychopathology questionnaire and were analyzed by SPSS 22 and LISREL 8/8.
Results: The hypothesized model of research is fitted with the experimental data. There was a significant relationship between attachment styles and psychopathology directly and indirectly. The results of path analysis indicated mediating role of the difficulties of excitement adjustment in the relationship between attachment styles and psychopathology.
Conclusion: Attachment styles and difficulties in excitement adjustment can be effective in preventing, diagnosing and treating of mental disorders, and promoting mental health of cosmetic surgery applicants.
Ensieh Lotfali, Akram Miraminmohammadi, Mahshid Shahrzad, Ali Khamesipoor, Alireza Firooz, Azam Fattahi,
Volume 11, Issue 1 (Volume 11, No 1 2020)
Abstract
Background and Aim: The aim of the present study is rapid and precise identification of yeast species isolated from nail of patients with clinical features of onychomycosis using PCR-RFLP technique.
Methods: 50 patients with involvement of 29 fingernails and 21 toenails were enrolled in the study. Different yeast species were identified by conventional mycological. The PCR-RFLP was tested on yeast isolated and the PCR-RFLP products were separated by electrophoresis in 2% agarose gel, with DNA stain.
Results: The main causative agents were yeasts in 12 cases (24%). Candida albicans was the most commonly isolated yeast species followed by Candida parapsilosis (6%), and Candida glabrata (4 %).
Conclusion: PCR-RFLP method using ITS1-ITS4 primers and MspI restriction enzymes is a rapid, accurate and cost-effective method for specific diagnosis of the most prevalent candida spp. Its ability to detect low amounts of fungal DNA in patient samples in 6-8 hours could be useful for clinical laboratories for optimal management of these infections.
Samira Shirmohammadi, Saeedehsadat Hosseini, Hassan Amiri,
Volume 11, Issue 2 (Volume 11, No2 2020)
Abstract
Background and Aim: Cosmetic surgery is one of the most common phenomena in recent decades. Due to high prevalence of psychiatric disorders among cosmetic surgery applicants, it is important to explore the pathways and variables affecting their mental health. The aim of this study was to investigate the mediating role of basic psychological needs in the relationship between attachment styles and psychopathology in women undergoing cosmetic surgery.
Methods: The research was descriptive and based on correlation models. Available sampling method was employed in order to gather data from 300 women referring to Kermanshah specialized surgical centres, for doing cosmetic surgeries. Collected data were analyzed employing attachment styles questionnaire, basic psychological needs and psychopathology, and by SPSS 22 and LISREL 8/8.
Results: The hypothetical model of the research fitted the experimental data. There was a significant relationship between attachment styles and psychopathology directly and indirectly. The results of path analysis indicated a mediating role for the difficulties of psychological needs in the relationship between attachment styles and psychopathology.
Conclusion: Attachment styles and basic psychological needs can be effective in preventing, diagnosing and treating of mental disorders, and promoting mental health of cosmetic surgery applicants.
Farasat Noormohammadifar, Alireza Soltanian, Pedram Alirezaei,
Volume 11, Issue 3 (Volume 11, No 3 2020)
Abstract
Background and Aim: Trichoscopy is a non-invasive diagnostic tool for hair diseases. The aim of this study was to evaluate the trichoscopic findings in different types of alopecia.
Methods: This cross-sectional study was conducted on 155 alopecia patients referring to Hamadan’s Sina hospital from March 2019 to July 2020. The patients were recruited after giving written informed consent. Scalp biopsy was performed to confirm the diagnosis and trichoscopic evaluation was then carried out. Trichoscopic findings along with demographic data were recorded. Data was analyzed using SPSS 16.0 software and appropriate statistical methods.
Results: A total of 155 patients including 79 males and 76 females were included in the study. The most common trichoscopic finding in alopecia areata was vellus hair (95.5%). The most common finding in androgenetic alopecia (AGA) was hair shaft thickness heterogeneity which was observed in all AGA patients. The most common findings in telogen effluvium (TE) were single hair pilosebaceous units, peripilar sign, thin terminal hairs and upright regrowing hairs which were observed in all TE patients. The most common finding in lichen planopilaris was perifollicular scaling (81.8%). The most common findings in discoid lupus erythematosus were large yellow dots (100%) and fine scaling (100%). Black dot was the most prevalent finding in tinea capitis (85.7%).
Conclusion: Trichoscopy ,as a non-invasive tool, could be helpful in differentiating different types of alopecia.
Mohammadreza Sobhan, Faezeh Mohammadi, Elham Khanlarzadeh, Mohammad Faryadras,
Volume 12, Issue 1 (Volume 12, No 1 2021)
Abstract
Background and Aim: Warts are benign tumors caused by different types of human papillomavirus. Different methods are used in the treatment of warts. The aim of this study was to compare the effectiveness, side effects and number of treatment sessions of CO2 laser and cryotherapy in the treatment of plantar warts
Methods: Seventy patients (140 feet) with plantar warts on both feet who referred to the dermatology clinic of Farshchian (Sina) Hospital in Hamadan during 2019-2020 were selected by convenience sampling method. The warts were randomly treated with either CO2 laser or cryotherapy on each foot. After treatment, patients were evaluated every two weeks for up to five sessions for requirement of treatment repetitions and assessment the extent of healing. In the cases with
non-healing lesion, treatment was repeated once every two weeks for up to five sessions.
Results: The mean age of the patients was 22.11±8.73 years, and 35.7% were male and 64.3% were female. In the CO2 laser and cryotherapy groups, the frequency of recovery rate was 81.4% and 41.4%, (P<0.001), and the mean number of treatment sessions was 1.90±0.84 and 3.55±0.69 (P<0.001) respectively. Frequency and type of side effects in the CO2 laser and cryotrapy group was pain 25.7% and 94.3% (P<0.001), itching zero and 32.9% (P<0.001), blisters 2.9% and 82.9% (P<0.001) and hyperpigmentation with zero and 12.9% (P=0.003), respectively.
Conclusion: CO2 laser is more effective than cryotherapy in less number of sessions and with less side effects for the treatment of plantar warts
Afsarolmoluk Hadadian, Azin Ayatollahi, Akram Miraminmohammadi, Mahshid Shahrzadkavkani, Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi,
Volume 12, Issue 3 (Volume 12, No 3 2021)
Abstract
Introduction: Dermatophytosis are micro-organisms which can lead to skin diseases. In rare occasions they can have atypical skin manifestations, which could result in delay in diagnosis.
Case Report: A 20-year-old Iranian boy was referred to our center with a 5-month history of circular, symmetrical, itchy crusted skin lesions on his groin. Direct microscopy, culture test and PCR-sequencing of ITS regions of the rDNA gene were conducted and showed T. indotinea as the causative agent. Based on antifungal susceptibility test oral pulse therapy with itraconazole 100 mg twice daily for 1 week combined with topical clotrimazole cream for 1 month was initiated, which cleared the lesions.
Conclusion: This case report is of significance since T. indotinea produces atypical skin lesions, as well as, multidrug resistance to antifungal agents.
Akram Miraminmohammadi, Minoo Tasbihi, Seyedebrahim Eskandari, Maryam Ahmadi,
Volume 12, Issue 4 (Volume 12, No 4 2022)
Abstract
Leishmaniasis is a neglected disease caused by different Leishmania species and transmitted by various sand flies. Iran is endemic to both visceral and cutaneous form of the diseases. The aim of this study was to investigate the epidemiological factors of leishmaniasis in patients referred to the Center for Research and Training Skin Disease and Leprosy from 1399-1400. The present study is a cross-sectional study in which every patient with suspected cutaneous leishmaniasis lesion(s) referred to the center during 1399-1400 were included. The results showed a higher number of patients with leishmaniasis are in the age group of 10 to 19 years. Among the mentioned jobs, a higher percentage was assigned to housewives in the affected women and workers in the affected men. According to the results, autumn is the most common season for cutaneous leishmaniasis. The average time from beginning to the diagnosis of leishmaniasis was 1.5-3 months and most patients showed a history of traveling to rural areas. The number of wet type lesions were higher than dry type and most of the lesions were in the hands. Most cases were reported from Isfahan province.
Seyedebrahim Eskandari, Ali Khamesipour, Alireza Firooz, Minoo Tasbihi, Akram Miraminmohammadi, Khadijeh Tavakoli, Maryam Ahmadi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background and Aim: Leishmaniasis is a parasitic disease transmitted by sandflies and is one of the endemic diseases of Iran. With the spread of the Covid-19 epidemic worldwide, the virus will interface with endemic infectious diseases in different regions. In this study, coronavirus disease was evaluated in patients with a history of leishmaniasis referred to the Center of Research and Training in Skin Diseases and Leprosy.
Methods: A total of 91 patients with a history of leishmaniasis were studied for possible SARS-CoV-2 infection. The number of patients referred to the Center of Research and Training in Skin Diseases and Leprosy during the coronavirus epidemic was also compared with the same period before the epidemic
Results: A total of 60% of patients with leishmaniasis
did not report coronavirus disease. Twenty-one percent of cases had a mild corona disease, 13% had a moderate and 3% had severe corona disease. Only a single death was reported in corona patients with a history of cutaneous leishmaniasis. The number of referrals before the beginning of the corona epidemic was twice as high as during the epidemic.
Conclusion: In these participants, mortality and side effects of COVID-19 were significantly less reported. However, further studies are needed to evaluate the immune system and cutaneous leishmaniasis protection against COVID-19. Various factors can be effective in reducing patients during the epidemic, including not going to medical centers, reducing the number of trips, and observance of health issues.
Minoo Tasbihi, Akram Miraminmohammadi, Ali Khamesipour, Seyedebrahim Eskandari, Alireza Firooz, Saman Ahmadnasrollahi,
Volume 14, Issue 2 (Volume 14, No 2 2023)
Abstract
Background and Aim: Cutaneous leishmaniasis is one of the most important health problems in Iran. There is still no effective vaccine available against human leishmaniasis and current treatment is based on chemotherapy. Conventional drugs are toxic and expensive, and drug resistance has caused the search for new treatments. Tofacitinib is a Janus kinase inhibitor that disturbs the signaling pathway of several cytokines in the immune system. The aim of this study was to evalute the effect of topical tofacitinib 2% ointment in healing cutaneous leishmaniasis in Balb/C mice.
Methods: This experimental study was performed using tofacitinib and glucantim drugs in 40 female Balb/C mice. The metacyclic form of promastigote of Leishmania major standard strain (MRHO/IR/75/ER) was injected into the footpad of the mice, the mice were divided into 4 treatment groups: tofacitinib, glucantim, tofacitinib-glucantim and control without treatment. The treatment period was 28 days. The footpad thickness of all groups was measured at the end of each week.
Results: After the end of the treatment in the groups treated with tofacitinib, a significant decrease in the size of lesion and the footpad thickness was observed compared to the control group without treatment (P<0.01).
Conclusion: It seems that tofacitinib ointment accelerates lesion healing in Balb/C mice and has worked similarly to standard glucantim treatment. Ointment can be a better option for leishmaniasis treatment and due to its ease of use and no need for painful injections it can be considered as an option for the treatment of patients with cutaneous leishmaniasis.
Homa Hatefi Minaei, Ali Khamesipour, Alireza Firooz, Akram Miraminmohammadi, Seyedebrahim Eskandari, Shahla Mirazizi, Minoo Tasbihi,
Volume 15, Issue 4 (Volume 15, No 4 2025)
Abstract
Background and Aim: Leishmaniasis is difficult to control and is not cost-effective in endemic areas. Antimony toxic compounds is the drug of choice, which drug resistance is increasing. Animal studies showed that interferon-gamma deficiency impairs the recovery of leishmaniasis. In this study, the therapeutic effects of subcutaneous injection of recombinant gamma interferon on leishmaniasis lesions in Balb/ C mice were evaluated.
Methods: 40 Balb/ C mice were infected with Leishmania major. After developing lesions, the therapeutic effects of interferon gamma alone or in combination with glucantime were investigated. Also, the standard treatment of glucantime and the control group without treatment were evaluated for comparison.
Results: The treatment groups (glucantime, gamma interferon, and gamma interferon-glucantime) had a significant difference (P<0.01) in terms of reduction in the footpad thickness compared to the control group. There was no significant difference in the mortality rate in the groups receiving gamma interferon and the group receiving standard glucantime treatment.
Conclusion: It seems that gamma interferon was effective in treating cutaneous leishmaniasis lesions in Balb/c mice alone and in combination with standard treatment and can be considered as an alternative treatment.
