Showing 30 results for Rat
Nasrin Zand, Afshan Shirkavand,
Volume 6, Issue 4 (1-2016)
Abstract
Postsurgical scars are of significant concern to both the patients and surgeons. Different laser systems have been used to accelerate and improve the healing process in surgical scars. Some studies have demonstrated the benefits of prophylactic laser application on pre-scars. It seems that using laser energy in the early phase of the healing process may produce changes in the physiology of wound healing toward a more fetal-like tissue regeneration and healing. Laser-Assisted Skin Healing (LASH) is a new approach in which laser irradiation is applied immediately after surgery in order to improve the resulting surgical scars. LASH produces controlled homogenous heating throughout the full thickness of the skin around the wound which accelerates wound healing without thermal damage to the tissue.
The purpose of this paper is to provide an overview of the available peer-reviewed research literature on the application of LASH, the in-vitro, animal and human studies and the suggested mechanisms of action. Further studies are necessary to optimize the best laser parameters especially according to different skin phototypes and better understanding of the mechanisms of action.
Ali Asghar Rezanejad, Mohammad Reza Sobhan, Hamid Reza Gsemi Basir, Akram Ansar,
Volume 7, Issue 2 (7-2016)
Abstract
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease due to benign proliferation of dermal and subcutaneous capillaries. It is most commonly seen in young to middle-age females. Skin lesions include single or multiple red papules, plaques and nodules. It most commonly involves head and neck. Its etiology has not been determined. ALHE lesions are usually resistant to commonly suggested treatment methods including surgery. Recurrence of treated lesions is also common. Herein, we report a 38-year-old pregnant woman who presented with multiple red papules and nodules on her periauricular and occipital skin. Her lesions were confirmed to be ALHE after histopathological assessment.
Mohammad Reza Abbasi Sarcheshmeh, Azra Mohammadpanah Ardakan, Abolghasem Abbasi Sarcheshmeh,
Volume 7, Issue 3 (10-2016)
Abstract
Background and Aim: Demand for cosmetic surgeries is very high, especially in Iran and is affected by economic, social and psychological variables. The aim of this study was to compare the beliefs about appearance, irrational beliefs and presentation of body mass in individuals who demand and who do not demand cosmetic surgery procedures.
Methods: This cross-sectional study was conducted at the Shahid Sadoghi Savaneh va Soukhtegi Hospital in Yazd in 2014. The questionnaires were given to 150 individuals who were looking for cosmetic surgery, of which 126 completed questionnaires were considered eligible for analyses.
Results: There was a statistically significant difference in BMI and beliefs about appearance between who demand cosmetic surgery and who do not (P=0.022, P=0.017, respectively). Those who were looking for cosmetic surgery had more irrational beliefs in comparison with who were not (P=0.017). Mean of irrational beliefs was higher in females than males, but there was no statistically significant difference in the means of beliefs about appearance among women and men (P=0.131). Also, the mean of beliefs about appearance and irrational beliefs scores both were higher among single people than married ones (P=0.049 and P=0.045, respectively).
Conclusion: Gender, BMI and cognitive characteristics, especially irrational beliefs regarding attractiveness played significant roles in the those demanding cosmetic surgery. We suggest that people consult dietitians and psychology counselors before making decisions about undergoing a cosmetic surgery procedure.
Amir Hooshang Ehsani, Maryam Nasimi, Pedram Noormohammadpoor, Arghavan Azizpoor, Fatemeh Golpayegani,
Volume 8, Issue 1 (4-2017)
Abstract
Background and Aim: The aim of this study was to evaluate surgery approach outcomes in patients with squamous cell carcinoma (SCC) of lower lip.
Methods: We retrospectively analyzed medical records of patients that diagnosed with SCC of the lower lip at Razi hospital at Tehran University of Medical Sciences in a 5 year period. Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher’s exact tests to compare the variables.
Results: The age range of patients was 35 to 94 years (mean, 64.1 years; SD, 13.27 years), with a 5:1 male-female ratio. SCC of the lower lip occurred more frequently in patients older than 60 years. 62.1 % of the patients were addicted to cigarette and other tobacco compounds. It was noted
significant association between chronic solar exposure in the job’s environment and incidence of SCC in lower lip. Mean diameter of the tumor was 28.1 mm (range, 5 to 63 mm). Recurrence was detected in 17 patients (24.6%). Two patients (2.89%) died due to lower lip SCC in this series.
Conclusion: our study revealed that lower lip SCC is more prevalent in men and in eighth decade of life. As well, considering the low recurrence rate and high survival rate, surgery could be considered as an effective method of treatment.
Ahmad Jafari, Nafiseh Esmaeili, Shamsolmoulouk Najafi, Hanie Emami Razavi,
Volume 8, Issue 4 (1-2018)
Abstract
Background and Aim: Oral cancer as the most common cancer of head and neck region holds the eighth rank among all cancers in order of prevalence. More than 90% of oral cancers are of squamous cell carcinoma (SCC). The main objective of this study is the determination of the survival rate in patients with oral SCC and the factors influencing thereon.
Methods: In this study, 174 recorded cases of patients with oral SCC were evaluated. Required data on survival of patients were gathered by phone calls. Using software SPSS 20, the statistical analysis of data was carried out. The survival rate of the patients and the corresponding influential factors were analyzed by the Kaplan-Meier curves and Cox regression tests, respectively.
Results: 57.6% of the patients were male. The age of the patients ranged between 22-89 years with the average onset age of 61.5 years. The most common site of oral SCC was tongue. The overall five-year survival rate of the patients was 49.4%±0.05. The survival rate had a statistically significant relation with age of the patients and their treatment methods, including surgery or chemotherapy.
Conclusion: The prevalence of oral SCC is higher in men and overall survival rate decreases with increasing age of the patients. Due to the low survival rate of oral cancer patients, more attentions should be paid to this condition.
Salar Hooshyar, Shohreh Nafisi, Khadijeh Ashtari, Bita Mehravi,
Volume 8, Issue 4 (1-2018)
Abstract
Diseases of the skin can cause harm and emotional distress in patients. The desirable drug is one with least complications and most effectiveness. By prolongation of target exposure, drug effectiveness could be improved. There are several suggested solutions, including the use of chemical enhancers, electroporation, iontophoresis, and the use of nanoparticles as carriers of pharmaceutical agents. The use of various nanostructures, including liposomes, dendrimers, autosomes, and many mineral nanoparticles, have been proposed to prevent the limitations with conventional formulations. Topical drug delivery has many benefits, including using high concentrations of the drug and reducing systemic passage of medicament. Many skin products, such as Estrasorb, Diractin and Aczone are available in the market with new and different manufacturing techniques for more skin penetration.
This paper introduces new approaches to drug delivery, types of nanocomposites and methods for increasing the penetration of pharmaceutical agents in the skin. Various factors such as physicochemical properties and the size of nanoparticles, as well as the effects of manipulation on the surface of these particles, have been discussed.
Seyed Majid Ghazanfari, Maliheh Motevaselian, Roshanak Salari,
Volume 9, Issue 1 (4-2018)
Abstract
Itching is a mental feeling that elicits desire to scratch and results from stimulation of itch, pain or palpation receptors in the skin. In Iranian medicine, itching is referred as hekka. Several factors can cause this symptom. Various drugs are used to treat itching. They are sometimes costly and not readily available and have side effects. Given the time-consuming and cost-effective processes for the discovery of effective drugs, new strategies are needed to reduce processes time and costs. One of these strategies could be the use of previous experiences on medicinal plants and spices used in traditional medicine schools.
In this review, we searched the keyword "itching, pruritus" in three reference books of pharmacology of Iranian medicine, including The Canon of Medicine (Al-Qanon fi al-Tibb), Tohfe Momenin, and Makhzan- Al' Advieh and ened up with a list of 60 multifaceted plants effective in improvement of pruritus. The efficacy of each of them was categorized based of available evidence. Therefore, it is recommended to use the rich experience of Iranian traditional medicine in the production of new drugs for pruritus.
Negar Sadeghi, Alireza Moradi, Jafar Hasani, Shahram Mohammadkhani,
Volume 9, Issue 2 (7-2018)
Abstract
Background and Aim: The cosmetic surgery is one of the prevalent phenomenons in recent decades. Body image is a key factor for interest in cosmetic surgery, but body image is a multidimensional concept and all its dimensions should be studied. This study aimed to study cognitive, emotional and behavioral dimensions of body image in women interested in cosmetic surgery.
Methods: This study was a cross-sectional research with causal-comparative method. A sample of 600 female students, age 18 to 35 years, were selected from universities in Tehran by using multi-stage cluster random sampling methid, who completed a set of questionnaires including “Beliefs About Appearance Scale (BAAS)“, “Body Areas Satisfaction Scale (BASS)“, “the Body Image Coping Strategies Inventory (BICSI)“ and Acceptance of Cosmetic Surgery Scale (ACSS). The collected data were analyzed by multivariate analysis of variance (MANOVA).
Results: The students who were interested in cosmetic surgery got a higher score in components of body investment as cognitive dimension and body dissatisfaction as emotional dimension. Among the three behavioral components of body image, there was significant difference only in appearance fixing coping (P<0.0001) and there were no significant differences in acceptance and avoidant strategies between students.
Conclusion: All of the cognitive, emotional and behavioral dimensions of body image are important in cosmetic surgery, and women interested in cosmetic surgery not only had body dissatisfaction, but also had dysfunctional attitudes about appearance important in interpersonal relationships, personal achievement and self-concept, and used strategies based on body modification. These findings can be used in prevention and intervention programs.
Hamidreza Ahmadi Ashtiani, Alireza Firooz, Hossein Rastegar, Amirhosein Askaripour,
Volume 10, Issue 4 (1-2020)
Abstract
A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.
Sara Bahrainian, Atefeh Naeimifar, Saman Ahmad Nasrollahi,
Volume 11, Issue 2 (7-2020)
Abstract
Habits since the introduction of the first commercial antiperspirant and deodorant, the use of these products have played an increasing role in a person's personal care. This article studies the physiology of human perspiration and responsible compounds for body odor. It also describes the function, classification, and differences between antiperspirants and deodorants.
Malahat Khateri Roodbordeh, Nahid Hassanzadeh Nemati,
Volume 11, Issue 4 (1-2021)
Abstract
Background and Aim: Lesions of the skin can impair its vital function to protect humans against external pathogens. Therefore, producing a suitable wound dressing to repair injuries is always one of the challenges of researchers. The present study aims to Synthesize a hydrogel film for wound dressing applications.
Methods: In this research, a hydrogel film of polyvinyl alcohol / hyaluronic acid / nano zinc oxide was fabricated for application as a wound dressing. For this purpose, three films with different percentages were prepared using the solvent casting method. The synthesized samples were characterized using FTIR, SEM, XRD, and tensile tests.
Results: Evaluation of the morphology of the samples showed that the increase of zinc oxide nanoparticles led to porosity and growth of their size in the films. It was also characterized that the percentage of film elongation increased with increasing nanoparticles of zinc oxide and hyaluronic acid. The elongation percentage from the lowest amount of nano zinc oxide to the maximum (5, 10 and 15% of weight was 159%, 166%, and 230%, respectively. The MTT study indicated the cell viability above 80% in all three films.
Conclusion: A film containing 15% zinc oxide can be a suitable option for using in tissue engineering and wound dressing.
Sepehr Zargaran, Soroush Mohitmafi, Ali Anisian,
Volume 12, Issue 1 (5-2021)
Abstract
Background and Aim: Alopecia by reduction of hair follicles at the wound healing site is a complication of cryosurgery that creates an unpleasant appearance in the scar of healed tissue. The aim of this study was to evaluate the effect of low level laser on preventing necrosis of hair follicles and increasing hair follicles in cryosurgery induced wounds.
Methods: Fifty male Wistar rats were randomly divided into 2 main experimental and control groups (with and without low power laser) and 5 subgroups. Histopathological examination of the amount of hair follicle count and angiogenesis at intervals of 3, 7, 14, 21 and 28 days was performed in the laboratory. SPSS software was used for statistical analysis.
Results: There was no significant difference in the angiogenesis had significantly index between the main groups on days 14 and 21 (P>0.05), but on days 3, 7 and 28, the experimental group had significantly higher angiogenesis than the control group. Throughout the days, both groups showed a significant increase in angiogenesis (P<0.05), except for the third and seventh days in the control group, and in both groups between the 21st and 28th days (P>0.05). In the comparison of hair follicle index, there was an increase on all days, which was significantly higher in the experimental group than the control group (P<0.05). However, no statistical difference was observed between the third and seventh days (P>0.05).
Conclusion: The use of low-power lasers on cryosurgery induced wounds with scars and alopecia can prevent hair follicles necrosis and subsequent increase in their numbers in rats.
Ensieh Lotfali, Zahra Cheraghi, Yasamin Farzaneh, Zakieh Dehbashi, Mahtab Dorrian, Mahyar Keymaram, Azam Fattahi,
Volume 12, Issue 2 (8-2021)
Abstract
Background and Aim: Onychomycosis is an infection caused by yeast, filamentous and non-filamentous fungi, due to diverse conditions. This study aimed to investigate the pattern of azole susceptibility of candidate species isolated from Iranian patients in Tehran.
Methods: After sampling from patients, identification of the isolated strains were performed with Candida chrom agar medium and PCR-sequencing test. Drug Susceptibility pattern of the species to fluconazole, itraconazole and ketoconazole were determined by CLSI-M27-A3/S4 standard method.
Results: In this study, 34 candidate isolates were identified, of which 26 isolates (76.5%) were Candida albicans and 8 isolates (23.5%) were Candida glabrata. In fluconazole, 4 (11%) of the isolates were dose-dependent sensitive and the others were sensitive. In itraconazole, 21 (61%) dose-dependent isolates and 2 (5%) resistant isolates were identified, and in ketoconazole, all isolates were sensitive. The geometric mean (GM) of the minimum inhibitory concentration for fluconazole, itraconazole and ketoconazole was 0.32, 0.21 and 0.15 μg/mL, respectively. In this study, the most frequently isolated species was C. albicans. According to the GM values, the most effective azoles was ketoconazole.
Conclusion: The prevalence and pattern of susceptibility of Candida species to azole may vary in different populations of patients. Therefore, it is recommended that the clinicians pay attention to the results of drug susceptibility tests and then treat patients by considering drug interactions and side effects.
Javad Rahmati, Zia Dadgar, Shahriar Haddady Abianeh, Sina Dadgar, Hojjat Molaei,
Volume 12, Issue 4 (2-2022)
Abstract
Background and Aim: This study is executed to compare two common reconstructive surgeries in suppurative hidradenitis.
Methods: Patients with severe supporutive hidradenitis who had operations to excise their axillary lesions and then treated with two standard surgical repair techniques (lateral thoracic flap vs parascapular pedicle flap) were evaluated in a retrospective cohort study. Assessments included range of motion of shoulder, scar objective measurments, and Dermatology Quality of Life Index questionnaire.
Results: Mean range of motion in flexion of parascapular flap and lateral thoracic flap were 176 and 175 degrees, respectively. Range of motion in abduction of parascapular flap and lateral thoracic flap were 166 and 147 degrees, respectively which is interesting according to future disabilities. Pigmentation, thickness, pliability and vascularization were objective scar measurements which there were not significant differences between groups. Patients` responses to questionnaire on their satisfaction of surgery did not differ significantly between two groups in any items of questionnaire. But summation of items took lower points in parascapular flap group versus lateral thoracic flap group.
Conclusion: Despite various reconstructive options in axillary skin defects following suppurative hidradenitis surgery, there is not a generalized agreement on best choice, and each technique has its advantages and disadvantages.
Zahrabeigom Moosavi, Kambyz Kamyab Hesari,
Volume 14, Issue 3 (11-2023)
Abstract
Introduction: Darrier disease is a genodermatoses evolving more in adolescence and appears mostly in seborrheic areas. Because of the absence of typical lesions and other diseases appearing in these areas, diagnosis of darrier may be delayed
Case report: A 46 year-old woman came with inguinal, asymptomatic lesions lesions since 3 years ago. The report of biopsy which was taken, showed findings compatible with Darrier disease. Oral isotretinoin initiated with good response after 2 months.
Conclusion: In intertriginous areas, some less common diseases may be mis diagnosed as other more common and similar diseases.
Mohammadali Esfandiary, Alireza Khosravi, Sepideh Asadi, Donya Nikaein, Jalal Hassan,
Volume 14, Issue 4 (2-2024)
Abstract
Background and Aim: Side effects associated with antimicrobial drugs, as well as their high cost, have stimulated the search for inexpensive herbal medicinals with fewer side effects. These substances can be used as a medicinal supplement or to increase the antimicrobial and antifungal effects of drugs. The aim of this study is to investigate the inhibitory effect of oleuropein on fungal and bacterial pathogens isolated from nail infection in laboratory condition.
Methods: Antifungal and antibacterial properties of oleuropein by determining the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) of this substance on yeasts Candida albicans, Candida glabrata and Escherichia coli by microbroth dilution method using CLSI protocols were evaluated.
Results: The results showed that the Minimum Inhibitory Concentration (MIC) against all three studied microorganisms was equal to 65 mg/ml and the Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) of oleuropein was equal to 130 mg/ml.
Conclusion: due to the high antifungal and antibacterial activity of oleuropein, the present study introduces oleuropein as a natural antimicrobial drug. This substance can also be used to increase the antimicrobial power of existing antibiotics.
Ala Ehsani, Bahar Sadeghi, Amirhoushang Ehsani, Mahshid-Ol- Sadat Ansari, Zahra Razavi, Mina Koohian Mohammadabadi, Kambiz Kamyab, Pedram Nourmohammadpour, Mobina Kamalabadi Farahani, Amirhossein Rahimnia,
Volume 15, Issue 3 (11-2024)
Abstract
Background and Aim: Angiokeratomas are rare vascular lesions, typically presenting as small red to purple macules or papules on the skin. These lesions are usually benign, though they can undergo changes in thickness and color over time. Certain types of angiokeratomas may also signal underlying metabolic disorders, necessitating careful clinical attention. This study aims to analyze the clinical and demographic features of angiokeratoma in Iranian patients at Razi Dermatology Hospital.
Methods: This descriptive, retrospective cross-sectional study examined 199 patients diagnosed with angiokeratoma between 2013 and 2023. Data on demographics, lesion characteristics (location and size), family history, and treatment methods were collected from medical records and analyzed using SPSS. Both parametric and non-parametric statistical tests were applied to assess associations, with a significance level set at 0.05.
Results: The mean age of patients was 24.75 years, with the second and third decades showing the highest prevalence. Among the patients, 51.3% were male and 48.7% female. Lesions most commonly appeared on the lower extremities (40.7%) and genital area (18.6%). Treatment methods included cryotherapy (68.14%), laser (27.14%), and electrodessication (4.44%), with cryotherapy proving the most effective among them.
Conclusion: This study provides valuable insights into the prevalence, clinical characteristics, and preferred treatment approaches for angiokeratoma in Iranian patients. Broader studies across various centers, along with long-term follow-up, are recommended to further investigate the clinical course, therapeutic outcomes, and potential complications associated with different treatment methods.
Azin Ayatollahi, Aliasgahr Ghaderi,
Volume 16, Issue 1 (5-2025)
Abstract
The indications for botulinum toxin have evolved tremendously since its introduction in 1989. This review highlights the potential of the use of BoNT based on the latest studies that indicate botulinum toxin injections may be beneficial as an alternative method of therapy in treating, among others, hyperhidrosis, hidradenitis suppurativa, Raynaud phenomenon, or anal fissure. Currently, there are numerous studies suggesting the effectiveness of botulinum toxin in the discussed diseases; however, it should be emphasized that the majority of evidence is based on low scientific quality publications and more clinical trials need to be conducted. Despite many favorable utilizations, the use of botulinum toxin is not without ramifications. To serve patients with relevant therapy and reduce related complications, dermatologists should be aware of both on- and off-label applications of botulinum toxin. Undoubtedly, a consensus on the treatment protocol for each indicator should be a topic of interest for practitioners to standardize all regimens with specific doses of BoNT.
Mehri Seyedmousavi, Alireza Homayouni, Seyedehtahereh Faezi, Ali Khanekeshi, Jamal Sadeghi,
Volume 16, Issue 2 (7-2025)
Abstract
Background and aim: The aim of the present study was to determine the effectiveness of cognitive-behavioral therapy on Alexithymia and pain coping strategies in women with lupus.
Methods: The research method was semi experimental with a pretest–posttest and two–month follow–up design with a control group. The statistical population of this research included all female patients with lupus who had referred to the Lupus Association in 2024 for lupus counseling and treatment. Among the statistical population, 30 qualified volunteers were available entered into the study and randomly assigned to two experimental and control groups (each group includes 15 people). The cognitive-behavioral therapy was implemented in the experimental group as 8 sessions one a week. Data analysis of the research was conducted using repeated measures analysis of variance and Bonferroni post-hoc test at a significance level of 0.05, with SPSS software version 27.
Results: The results indicated that the effect of time, the effect of group, and the interaction effect of time and group on emotional distress scores and pain coping strategies were significant (p<0.001). In the intervention group, there was a significant difference in Alexithymia scores and pain coping strategies between the pre-test and post-test stages, as well as between the pre-test and follow-up (p<0.001). However, no significant difference observed between the post-test and follow-up for these variables.
Conclusion: This research showed that teaching the cognitive-behavioral therapy to women with lupus is suitable for improving alexithymia and pain coping strategies.
Sepehr Bazrafkan, Afshan Shirkavand, Elaheh Nahvifard,
Volume 16, Issue 3 (11-2025)
Abstract
Cutaneous warts are among the most common benign skin lesions and, due to their high prevalence, risk of infection, and cosmetic concerns, they remain a frequent focus of clinical attention. Among the available treatment modalities, cryotherapy is widely used as a first-line option owing to its simplicity, low cost, and high success rate. However, the optimal choice of probe temperature and freeze duration still largely relies on clinical experience, and uncertainties in tissue thermal parameters may result in incomplete treatment or unintended damage to surrounding healthy tissue.
In this study, a numerical model was developed to investigate the temperature distribution within human skin during the cryotherapy of warts. The model is based on the radial heat-conduction equation and incorporates temperature-dependent thermophysical properties of human skin as reported by Agafonkina et al. (2021). Simulations were performed for a range of probe surface temperatures between -30 °C and -70 °C, and the temporal evolution of the wart center temperature was examined until it reached the cellular destruction threshold. The results indicate that lowering the probe temperature accelerates the freezing process; however, below approximately -55 °C, this enhancement becomes saturated and the risk of collateral tissue damage increases. Based on the obtained optimization map, the optimal probe temperature was found to lie within the interval -45 to -55 °C, for which the wart core reaches the critical temperature (-20°C) within 5 to 8 seconds. Comparison with clinical data demonstrates that the developed numerical model can serve as an effective tool for predicting and optimizing cryotherapy parameters, thereby improving treatment precision and reducing the likelihood of clinical error.
