Showing 133 results for No
Ensieh Lotfali, Adel Shirani, Sina Molavizade, Sa’adat Shojaei,
Volume 13, Issue 1 (5-2022)
Abstract
Onychomycosis is a nail infection caused by dermatophyte and non-dermatophyte molds and yeasts. The nail involvement is a feature of psoriasis, although skin manifestations are the most principal findings in psoriasis. Onychomycosis and psoriasis are both common disorders in communities. It is possible that in some patients these two diseases are present at the same time. A review was performed using the keywords including nail psoriasis, onychomycoses, dermatophytes, non-dermatophyte molds and yeasts in valid medical databases, such as PubMed, Google scholar, Scopus and Science direct. Articles that were most relevant to the purpose of the study were selected and studied. We investigated the incidence and pathogenic function of fungal agents in causing fungal infections in psoriasis nails.
Mansour Nassiri Kashani,
Volume 13, Issue 2 (8-2022)
Abstract
No Abstract No Abstract
Pegah Abbasi, Maryam Peymani, Dariush Farhud, Hamidreza Mahmoudi, Kamran Ghaedi,
Volume 13, Issue 2 (8-2022)
Abstract
Background and Aim: Considering the high global incidence of skin cancer and the high mortality rate caused by melanoma, it is important to identify the genes involved in this disease and predict effective drugs. Therefore, in this study, we have identified and investigated the expression level of effective and key genes in melanoma metastasis, as well as investigating their diagnostic potential as biological markers and finding effective drugs on the expression of these genes.
Methods: In this study, we have used 46 cancer samples without metastasis and 12 cancer samples with metastasis from the GEO database and from the GSE15605 study with 74 samples including 16 normal samples. Gene expression profile in this study was generated by GPL570 platform containing 54675 probes. The latest GPL570 annotation file has been downloaded and initial processing was done.
Results: The results showed that the expression level of candidate genes in metastasis samples had a significant change compared to normal samples. The results of analysing the data related to candidate genes in this study indicated that the drugs Glucosamine, Ad-E2F-1 plus Doxorubicn, GSI, Torcetrapib, Ribavirin and NSC319726 could be effective on the expression of MYH10, SPRR3 and TOP2A genes, respectively. On the other hand, the results from the drug bank database revealed that various drugs such as Amsacrine, Dexrazoxane, Valrubicin, Teniposide can have an inhibitory role on the TOP2A gene.
Conclusion: GEO database was used to identify key genes in melanoma metastasis and DRUGBANK was used to identify drugs that affect the expression of these genes.
Fatemeh Yazdani Hamid,
Volume 13, Issue 2 (8-2022)
Abstract
Skin cancers are highly prevalent malignancies that affect millions of people worldwide. These include melanomas and nonmelanoma skin cancers. Melanomas are among the most dangerous cancers, while nonmelanoma skin cancers generally exhibit a more benign clinical pattern; however, they may sometimes be aggressive and metastatic.
Melanomas typically appear in body regions exposed to the sun, although they may also appear in areas that do not usually get sun exposure. Thus, their development is multifactorial, comprising endogenous and exogenous risk factors. The management of skin cancer depends on the type; it is usually based on surgery, chemotherapy, immunotherapy, and targeted therapy. In this respect, oncological treatments have demonstrated some progress in the last years; however, current therapies still present various disadvantages such as little cell specificity, recurrent relapses, high toxicity, and increased costs. Furthermore, the pursuit of novel medications is expensive, and the authorization for their clinical utilization may take 10-15 years. Thus, repositioning of drugs previously approved and utilized for other diseases has emerged as an excellent alternative. In this mini-review, we aimed to provide an updated overview of drugs’ repurposing to treat skin cancer and discuss future perspectives.
Bahareh Nowruzi,
Volume 13, Issue 2 (8-2022)
Abstract
One of the most important functions of the skin is to protect against various stressors. Environmental stimuli such as UV and environmental pollution increase reactive oxygen species and cause wrinkles and skin aging. Skin aging is associated with decreased collagen production and decreased activity of enzymes involved in collagen structure. Moisturizing chemicals increase the skin's ability to retain water, but long-term use can have adverse effects on human skin, such as allergies and even tumorigenic effects. As a result, the use of biological resources, especially photosynthetic organisms such as cyanobacteria, as safe alternatives is increasing. The mechanism by which cyanobacteria respond to ultraviolet radiation is the synthesis of ultraviolet compounds such as mycosporin-like amino acids and scytonemin. In addition, the exopolysaccharides produced by some species that live in extremely dry habitats can be used as moisturizers in cosmetics. In this study, we introduce the potential of cyanobacterial metabolites as alternative sources for sunscreens and moisturizers.
Mansour Nassiri Kashani,
Volume 13, Issue 3 (11-2022)
Abstract
No Abstracts No Abstracts No Abstracts
Poorandokht Afshari, Maryam Beheshtinasab, Mohamad Javadmohamadi, Elham Maraghi, Maria Cheraghi,
Volume 13, Issue 3 (11-2022)
Abstract
Background and Aim: Importance of hand hygiene with the COVID-19 has been raised around the world from 2019. We aimed to determine the effect of hand skin health in menopausal women during the covid-19 pandemic.
Methods: It was a cross-sectional study which has conducted on 94 subjects those were referred to menopause clinic in Imam Khomeini Hospital in Ahvaz city during September to November 1999. The tools of this study were the Personal Characteristics Questionnaire and Hand and skin self-assessment tool (Appendix 3 of “WHO GUIDELINES ON HAND HYGIENE IN HEALTH CARE “). Data has entered and analyzed by using software SPSS version 22. The level of significance was considered as less than 0.05.
Results: The mean age of women participating in the study was 53.6. The average frequency of hand washing outdoors was 5.28 and 10.43 indoors. Most women (94.7%) had reported at least some degree of skin problem and reported that their hand skin problems increased significantly during the COVID-19 pandemic.
Conclusion: Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.
Seyedsajad Alenabi, Atefeh Naeimifar, Sara Bahrainian, Saman Ahmadnasrollahi,
Volume 13, Issue 3 (11-2022)
Abstract
Cosmeceuticals are the fastest growing segment of the personal care industry, and a number of topical cosmeceutical treatments for conditions such as photoaging, hyperpigmentation, wrinkles, and hair damage have come into widespread use. In the cosmeceutical arena nanotechnology has played an important role. Using new techniques to manipulate matter at an atomic or molecular level, opening up new perspectives for the future of cosmeceutical industry. Nanotechnology-based cosmeceuticals offer the advantage of diversity in products, and increased bioavailability of active ingredients and increase the aesthetic appeal of cosmeceutical products with prolonged effects. However increased use of nanotechnology in cosmeceuticals has raised concern about the possible penetration of nanoparticles through the skin and potential hazards to the human health. This review outlines the different nanoparticles used in various classes of cosmeceuticals, and the potential risk caused by nanoparticles on exposure.
Amirhoushang Ehsani, Arezou Jammanesh, Amirali Jahanshahi, Elnaz Khosravani, Reza Robati, Zahra Saffarian, Alireza Firooz, Vahide Lajevardi, Parvin Mansouri, Mansour Nassiri Kashani,
Volume 13, Issue 4 (2-2023)
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, internal medicine specialists, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.
Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2018. The current guideline is the result of scientific papers that got published from April 2018 to August 2022.
Taravat Bahrami, Soroush Mohitmafi, Fariborz Moayer,
Volume 13, Issue 4 (2-2023)
Abstract
Background and Aim: The purpose of this study is to investigate the histopathology and immunohistochemistry of the effect of 5% Plantago labceolata. extract on open wound healing in rat skin.
Methods: After extracting the plant extract using the mixed method, 40 healthy male rats with an average weight of 200-250 grams were selected and randomly divided into two main groups of 20. Group 1 is the treatment group and group 2 the control group each of the main groups being divided into 4 subgroups (days 3, 7, 14,21) were divided. For the histopathological and immunohistochemical investigation of the healing process, the wounds of the mice of the subgroups in both the main groups were removed in full thickness and with a diameter of 15 mm and examined for histological studies. After sectioning, with the qualitative staining method of hematoxylin eosin and Masson's trichrome,using antibodies against transforming growth factor beta and vascular endothelial growth factor of the study groups, and the obtained information was converted into quantitative information. and was subjected to statistical analysis.
Results: Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.
Conclusion: The results show that it is possible to use the polar extract of Plantago Lanceolata L. plant 5% for wound healing.
Sharareh Rezaeian, Hamidreza Pourianfar,
Volume 13, Issue 4 (2-2023)
Abstract
Reishi mushroom (Ganoderma lucidum) is a unique medicinal mushroom that has been used for the treatment of various diseases in Asian countries for more than 4 thousand years. Today, this mushroom is also used in treatments related to traditional medicine. In addition to its diverse biological properties, its positive effects in improving the quality of the skin and treating skin diseases have attracted the attention of researchers. Polysaccharides and triterpenes are among the most important and effective metabolites of this mushroom, which are important in skin treatment and health due to their antioxidant and anti-inflammatory functions. This review summarizes the latest research achievements on the role of this mushroom in skin health and treatment. A number of studies have shown that the extracts of Reishi mushroom can accelerate wound healing, relieve post-burn infections, and prevent skin flaps due to ischemia (re-perfusion) damage. The effect of Reishi mushroom extracts on the prevention and treatment of wrinkles and the effect on skin whitening has made them a natural ingredient for skin care. Also, studies conducted on the effects of Reishi mushroom in the treatment of some skin diseases such as atopic dermatitis (eczema), cutaneous sarcoidosis, and the potential use of this mushroom in the treatment of skin cancer have been discussed.
Atoosa Asadollahi, Bahareh Nowruzi, Mahsa Fattahi,
Volume 13, Issue 4 (2-2023)
Abstract
Microalgae are photosynthetic microorganisms which are the result of permanent exposure to stressful conditions such as high or low temperature, high salinity, osmotic pressure, ultraviolet radiation (uv), contain valuable bioactive compounds in cosmetic products .the existing cosmetic products can be replaced with the cosmetic products that are compatible with the environment and can be included in the topical formulations of skin care such as moisturizers, Anti-wrinkles, anti - aging and anti - acne. In addition, the extracts from these microalgae are used to make sunscreen to treat skin pigmentation and improve wounds; therefore most commercial cosmetics have a wide range of natural compounds extracted from cyanobacteria and this leads to increasing antioxidant, regenerative, moisturizer, shielding and brighteners for both hair and skin. In this article the cosmetic use of cyanobacteria extract and dried powder in improving the appearance and health skin have been investigated. Furthermore, analyzing the brand of Spirulina has been discussed.
Mansour Nassiri Kashani,
Volume 14, Issue 1 (5-2023)
Abstract
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Mansour Nassiri Kashani,
Volume 14, Issue 3 (11-2023)
Abstract
No Abstract No Abstract
Farnaz Valizadeh,
Volume 14, Issue 3 (11-2023)
Abstract
Virtually all deaths in young patients with advanced skin tumors are caused by melanoma. Today, thanks to modern treatments, these patients survive longer or can even be cured. Advanced melanoma is often associated with a poor prognosis, and physicians continue to believe that the disease is difficult to treat due to the lack of durable response to initial treatment regimens and the lack of randomized clinical trials in the post-immunotherapy/targeted molecular therapy setting. New therapeutic targets are emerging based on preclinical data on the genetic profile of melanocytes and the identification of molecular factors involved in the pathogenesis of malignant transformations. In this article, we present the challenges of diagnosis, molecular biology and genetics of malignant melanoma, as well as current treatment options for patients with this diagnosis.
Pegah Tamimi, Parham Tamimi, Aliasghar Ghaderi,
Volume 14, Issue 4 (2-2024)
Abstract
Dysregulation of long non-coding RNA may lead to various diseases including cancer. Recently, many lincRNAs have been discovered for their important roles in melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). These long non-coding RNAs are involved in skin cancer cell proliferation, angiogenesis, invasion, and metastasis.
Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.
Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.
Mansour Nassiri Kashani,
Volume 14, Issue 4 (2-2024)
Abstract
No Abstract No Abstract
Mansour Nassiri Kashani,
Volume 15, Issue 1 (5-2024)
Abstract
No Abstract
Negar Asghari Hosori, Zeinab Bagheri,
Volume 15, Issue 2 (8-2024)
Abstract
The limitations of common needles in drug delivery, such as pain, infection, and side effects, have become a stimulus to search for more efficient alternatives. Meanwhile, microneedles have brought new hope in skin drug delivery. These microstructures are temporarily placed in the upper layers of the skin and provide a painless and non-invasive way for drugs to pass through the skin barrier. Diversity in the design and ingredients of microneedles allows the release of a wide range of drugs with high efficiency and low side effects. On the other hand, nanomedicines are proposed as an ideal alternative due to the limitations of traditional drugs and the need for more targeted and less detrimental options. Nanomedicines are new drug delivery systems that are designed and produced in nanometer dimensions. These small particles can carry and release drugs directly to the target cells with high precision and efficiency. By reducing side effects and increasing the effectiveness of treatment, nanomedicines can play a key role in improving the quality of treatment for various diseases. Considering the unique advantages of the combination of microneedles and nanomedicines, it is an important issue to investigate different strategies for using these new systems in drug release. In this article, this issue has been investigated as well as the applications of nanomedicine transfer by microneedle in the treatment of diseases and the upcoming challenges of this emerging technology.
Mansour Nassiri Kashani,
Volume 15, Issue 3 (11-2024)
Abstract
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