Showing 33 results for Treatment
Tahereh Soori, Nafiseh Esmaeili, Mostafa Mirshams-Shahshahani, Mohammad Reza Poursadati, Abbas Karimi,
Volume 5, Issue 4 (1-2015)
Abstract
Background
and Aim: The standard treatment regimen for pemphigus is
adminitration of systemic corticosteroids and adjuvant agents. Previous studies
have shown that corticosteroid therapy may alter lipid profile and reduce the
atherogenic index in some disorders. This study was conducted to evaluate
the changes in lipid profile in pemphigus patients treated with oral
corticosteroids alone or in combination with adjuvants.
Methods:
In this retrospective corss-sectional study, medical records of 148 pemphigus
patients admitted in Razi Hospital in Tehran were reviewed for serum levels of
low-density lipoprotein (LDL), high-density lipoprotein (HDL), total
cholestrol, and triglyceride on the day of admission till 3 weeks after
initiation of the treatment.
Results:
Fifty-eight percent of patients were female and the mean age of the patients
was 47.1 years. 79.3% and 13.3% of patients had been treated with prednisolone
plus azathiorine or prednisolone alone, respectively. The remainig patients
were treated by administration of oral prednisolone and other adjuvants. Serum
levels of LDL, HDL, total cholestrol and triglyceride were significantly higher
3 weeks after initiation of treatment compared to baseline (P<0.05). With
the exception of the signifcantly higher level of triglycerides in women, there
was no statistically significant association between the levels of other serum
lipids at the end of 3 weeks treatment with gender, age, severity of the
disease, use of statins, and the treatment regimen (P>0.05).
Conclusion:
Although the level of different components of the lipid profile in Iranian
patients with pemphigus changed after receiving treatment for 3 weeks, it seems
that those changes were not associated with an increased atherogenic index of
pemphigus patients.
Zahra Hallaji, Alireza Khatami, Reza Robati, Hassan Seirafi, Alireza Firooz, Vahideh Lajevardi, Zoherh Mozafari, Parvin Mansouri, Pedram Mehryan, Mansour Nassiri-Kashani,
Volume 6, Issue 1 (4-2015)
Abstract
Urticaria is a common and challenging skin disorder. Its diagnosis and treatment is not limited to the field of dermatology. General physicians, and allergologists and clinical immunologists are also commonly involved in the management of urticaria patients.
One of the missions of the Iranian Society of Dermatology is to develop strategies to provide the best possible management for patients suffering dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Mohammad Saatchi, Hamid Salehinia, Salman Khazaei, Mahdi Mohammadian, Abdollah Mohammadian-Hafshejani,
Volume 6, Issue 2 (7-2015)
Abstract
Background and Aim: The aim of this study was to investigate various aspects of the treatment in patients with cutaneous leishmaniasis in Iran in the first half of 2014.
Methods: This cross sectional study was conducted on the existing data of 3684 patients with cutaneous leishmaniasis, whom were registered at the Disease Management Center of the Iranian Ministry of Health in the first half of 2014. Version 11 of Stata was used for statistical analysis and the level of significance was considered equals to 0.05.
Results: Of 3684 patients entered into the study (%55.1) were male and the mean age of the patients was 27±18 years. More than 34% of patients were treated with intralesional injections of meglumine antimoniate (MA) and 25% of patients recieved systemic MA injections. There were statistically significant correlations between the size and number of the lesions and the chosen treatment regimen (P<0.001). Thirty-five percent of patients treated with systemic MA between 7 to 10 days and 43.3% of patients recieved intralesional MA injections for 5 to 8 weeks.
Conclusion: More than %99 of patients fully recovered without complication or treatment failure. It seems that Iranian patients suffered milder CL in comparison with some other coutries.
Mohsen Sheykhhasan, Hossein Bakhtiari Pak, Mahdieh Ghiasi,
Volume 7, Issue 3 (10-2016)
Abstract
Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. PRP has been applied to bedsores to promote healing. Over the last decade, it has been used as a valuable therapeutic method in various specialties such as maxillofacial surgery, plastic surgery, orthopedics and sports medicine. Only recently has PRP been utilized for dermatologic purposes, psrticularly, for the treatment of male and female pattern hair loss.
In this review, we discuss molecular and cellular pathways up-regulated by PRP important in hair folliculogenesis, and examine clinical evidence from all previously published studies involving the use of PRP for pattern hair loss.
Marjan Entezami, Bahareh Malek Afzali, Roghayeh Jebreili, Bita Shahbazzadegan,
Volume 7, Issue 4 (1-2017)
Abstract
Background and Aim: Vitiligo is a common pigmentary disorder that melanocytes are destroyed. Treatment of vitiligo depends on the extent of the disease and its distribution pattern. The aim of this study was to compare the efficacy of PUVA and NBUVB in patients with vitiligo.
Methods: A clinical trial has been performed on 60 patients with vitiligo referred to Bouali hospital and Mehrgan laser center in 1392 and treated with UVB and PUVA therapy methods. In first group treated with PUVA, oral tablets containing 8-methoxypsoralen were taken 3 hours before phototherapy twice a week. The second group was treated with NBUVB twice a week.
Results: In patients treated with PUVA, 40% and in patients treated with NBUVB, 43.3% were male. Seventeen (56.7%) of patients treated with PUVA had generalized vitiligo, 30% of them had segmental Vitiligo and 13.3% had focal Vitiligo. Seventeen (56.7%) patients that were treated with NBUVB generalized vitiligo, 30% had segmental and 10% had focal vitiligo. Repigmentation was significantly higher in patients treated with NBUVB than PUVA 3 and 6 months after initiation of treatment (P<0.05).
Conclusion: NBUVB is superior to PUVA in treatment complications and its recovery rate was acceptable.
Khadijeh Tavakoli, Zahrabeigom Moosavi Moosavi, Kambiz Kamyab,
Volume 9, Issue 2 (7-2018)
Abstract
Introduction: Idiopathic granulomatous mastitis (IGM) is a rare benign breast disease. The importance of this disease relies on its similar clinical manifestation to those of mammary carcinoma and a group of mastitis with other causes.
Case Report: The patient was a 32-year-old woman, that suddenly got fever, pain and swelling in left breast. In examination several masses were felt. Performed core needle biopsy reported IGM.
Conclusion: Similarity of clinical presentations and diagnostic tests to the other kinds of mastitis and malignancies may lead to misdiagnosis and mistreatment, which imposes socioeconomic and psychological burden to patients.
Alireza Firooz, Vahideh Lajevardi, Parvin Mansouri, Nassiri-Kashani Mansour, Yasaman Norouzi, Farhad Handjani,
Volume 9, Issue 3 (10-2018)
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.
Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2015. The current guideline, with respect to scientific papers that got published from 2015 to August 2018, is the update it.
Saman Ahmad Nasrollahi, Behnaz Daneshmand, Najva Kashani,
Volume 9, Issue 3 (10-2018)
Abstract
Pediculosis infection is seen in all age group and different societies and several treatment have been suggested and marketed. In this study, we try to explain the difference of anti-lice products in Iran. Also it is necessary to mention that Anti-lice products are not effective alone, therefore to eliminate head lice infection the use of appropriate anti-lice combs is recommended.
Rozita Davoodi, Rafat Gerayeli, Elnaz Soltani, Najmeh Mohajeri, Zahra Khani, Nahid Jalalian Elahi,
Volume 9, Issue 4 (1-2019)
Abstract
Background and Aim: Among destructive treatments for removal of unwanted hair, hair removal laser devices have widely replaced the old fashion methods due to their safety and effectiveness. The purpose of this study was to analyze the effective factors on treating unwanted hairs with a laser device.
Methods: This retrospective study, was performed on records of 122 patients who referred to a hair and skin clinic .Patients with hirsutism or other diseases were excluded. Hair thickness and color, skin color, number of laser sessions, age and sessions interval were evaluated. The collected data were analyzed by compeutering program SPSS version 21, analytic tests chi-square and logistic regression (P less than 0.05 considered meaningful).
Results: The average age of participants was 31.3±6.6 years. The average number of laser sessions was 5.4±2.1 and the most satisfying outcome was observed in dark hairs and more than 5 sessions (P<0.05). Multivariate logistic regression model illustrated that the number of sessions directly impacts the effectiveness of treating unwanted hair (P<0.05). Level below the rock curve and the sensitivity were 0.71(0.61-0.81) and 0.759, respectively.
Conclusion: This study showed that hair thickness and color, number of laser sessions are important factors on hair removal treatments by laser. For optimal outcome more sessions with longer follow up is recommended.
Behnaz Daneshmand, Saman Ahmad Nasrollahi,
Volume 9, Issue 4 (1-2019)
Abstract
Rosacea is a chronic inflammatory disease which presents with condition with a prevalence erythema and inflammatory lesions on central face.
Rosacea has significant impact on quality of life of patients hence lowering confidence and harmful for social positions Study of effective medications improves quality of life of patients. In this study we tried to review effective medical treatments for this disease.
Rezvan Amiri, Saman Mohamadi, Maryam Khalili, Ali Fatehi, Asma Sabermahany, Mahin Aflatoonian,
Volume 12, Issue 1 (5-2021)
Abstract
Background and Aim: Care of patients with skin diseases may lead to high financial costs and burden on health system for societies and family members. In this study, we decided to evaluate the costs of treatments of patients admitted in the dermatology ward of Afzalipour Hospital, Kerman.
Methods: This is a retrospective, cross-sectional study performed from 2011 to 2017 on patients admitted in the dermatologic ward of Afzalipour Hospital. Demographic features of patients, duration of admission, cost of treatment, number and type of prescribed drugs as well as the patients’ and insurance organizations’ shares of the cost were recorded.
Results: In this study, 940 patients were evaluated for six years. The mean age of the patients was 38.05±22.35 years and most of them were female. The mean duration of admission was 8.42±2.54 days. The insurance companies’ and patients’ shares of the fees were 93.8% and 6.2%, respectively. The highest costs belonged to prescribed drugs (37.9%) and hoteling (30.3%). The most common prescribed drugs were antihistamines (33.1%), topical steroids (27.7%) and systemic steroids (24.5%). The mean number of prescribed drugs in each admission was 6.30±4.02 (range
0-20). Patients suffering from Erythema and urticaria had the total highest costs of admission (81,360,000 Iran Rials).
Conclusion: In this study, the most frequent skin diseases were infectious and papulosquamous diseases. The highest and lowest cost of admission belonged to prescribed drugs and consultations, respectively. Also, the highest cost of admission belonged to patients with erythema and urticaria.
Ehsan Zarei, Atefeh Gholamhosseini, Narges Ghandi,
Volume 12, Issue 3 (11-2021)
Abstract
Background and Aim: Psoriasis is a systemic and non-transmissible chronic inflammatory autoimmune skin disease that about 2-3% of Iranians suffer from it. Cost of management and budgeting and planning for the treatment of patients with psoriasis requires accurate information. The present study estimates the direct and indirect costs for one-year treatment of patients admitted in Razi Dermatology Hospital.
Methods: In this descriptive-analytical study, treatment costs of 170 patients with psoriasis, including direct (medical and non-medical) and indirect costs were evaluated by census method and using a researcher-made checklist, from October 2017 to October 2018. The fee was collected through reviewing patients' bills in the hospital information system and through telephone interviews with patients.
Results: The average cost of one year was 9037480 Tomans ($ 758), of which direct cost of treatment was 90.22% (8178681 Tomans) and indirect cost of treatment was 9.78% (858799 Tomans). The highest cost of treatment was related to pharmaceutical services with 5825233 Tomans. Also, the total direct medical cost was equal to 7069890 Tomans, of which 62% was the insurance share and 38% was the patient share. The findings showed that injecting biological drugs and accommodation had a significant effect on the direct cost of treatment. Supplementary insurance and accommodation variables also affect out-of-pocket costs.
Conclusion: Drugs made up most of the costs. The high price of biologics and the low coverage of these drugs by insurance companies have caused many economic problems for these patients. According to the findings of this study, it seems necessary to review the more complete insurance coverage of these drugs as well as the use of charitable assistance to cover part of the cost for treatment.
Hamideh Herizchighadim,
Volume 13, Issue 1 (5-2022)
Abstract
COVID-19 pandemic has led to many mortalities since the beginning of 2020. As there was no previous experience, no specific therapy was used, except for gloves, masks, special clothes, and antiseptics. So various pharmacologic and
non-pharmacological treatments were tried. World Health Organization published therapeutic protocols in the first weeks of the pandemic that has been changed over months. As there are constant and variable signs and symptoms in different patients in different countries, therapeutic modalities and drugs are various too. Some of these drugs have been used for viral and nonviral diseases, including Tamiflu (that has been used in the treatment of influenza), Ribavirin (an effective drug in hepatitis C infection), immunoglobulin (that has been used in the treatment of various disorders like Stevens-Johnson syndrome), hydroxychloroquine (for the treatment of systemic lupus erythematosus and other rheumatologic disorders), azithromycin (that is used for upper respiratory tract infections, acne, etc.). On the other hand, consuming spices such as ginger and turmeric, vitamins like vitamin C and vitamin D, and zinc supplements have been suggested. Over months, treatment complications, including side effects of drugs and protective equipment appeared. Complications included a broad spectrum of pruritus and nonspecific rash to Stevens-Johnson syndrome and angioedema. Aggravation and recurrence of dermatitis due to the use of protective equipment and antiseptics have been observed. Increasing knowledge about treatment complications will result in early diagnosis and management and obviously decreasing mortality rates and costs.
This article is a review of common cutaneous side effects of therapeutic modalities and preventive methods in COVID-19.
Amirhoushang Ehsani, Arezou Jammanesh, Amirali Jahanshahi, Elnaz Khosravani, Reza Robati, Zahra Saffarian, Alireza Firooz, Vahide Lajevardi, Parvin Mansouri, Mansour Nassiri Kashani,
Volume 13, Issue 4 (2-2023)
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, internal medicine specialists, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.
Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2018. The current guideline is the result of scientific papers that got published from April 2018 to August 2022.
Sharareh Rezaeian, Hamidreza Pourianfar,
Volume 13, Issue 4 (2-2023)
Abstract
Reishi mushroom (Ganoderma lucidum) is a unique medicinal mushroom that has been used for the treatment of various diseases in Asian countries for more than 4 thousand years. Today, this mushroom is also used in treatments related to traditional medicine. In addition to its diverse biological properties, its positive effects in improving the quality of the skin and treating skin diseases have attracted the attention of researchers. Polysaccharides and triterpenes are among the most important and effective metabolites of this mushroom, which are important in skin treatment and health due to their antioxidant and anti-inflammatory functions. This review summarizes the latest research achievements on the role of this mushroom in skin health and treatment. A number of studies have shown that the extracts of Reishi mushroom can accelerate wound healing, relieve post-burn infections, and prevent skin flaps due to ischemia (re-perfusion) damage. The effect of Reishi mushroom extracts on the prevention and treatment of wrinkles and the effect on skin whitening has made them a natural ingredient for skin care. Also, studies conducted on the effects of Reishi mushroom in the treatment of some skin diseases such as atopic dermatitis (eczema), cutaneous sarcoidosis, and the potential use of this mushroom in the treatment of skin cancer have been discussed.
Amirhoushang Ehsani, Hasan Hajmohammadtaghiseyrafi, Pedram Nourmohammadpour, Mahdi Naghdipour, Mina Koohian Mohammadabadi, Ala Ehsani, Amirhossein Rahimnia,
Volume 14, Issue 1 (5-2023)
Abstract
Background and Aim: Lower limb telangiectasias are commonly seen in the general population and especially in females. This disorder not only causes cosmetic problems but also can cause pain and related problems of increased venous blood pressure. These varicose veins are one of the most common causes that patients refer to dermatology clinics. Considering some complications and limitations of sclerotherapy, we decided to investigate the efficacy and safety of the Long-Pulsed Nd:YAG 1064-nm laser as an alternative method.
Methods: 29 patients underwent at least three sessions of 1064 nm Nd: YAG laser treatment at intervals of 4 weeks. Before the first treatment session, after each session, and six months after the last session, photos were taken of the treatment site. Finally, clinical response and satisfaction rate with the treatment were recorded based on the score of a secondary dermatologist and the patient himself based on the improvement criteria from 0 to 4.
Results: According to the dermatologist's judgment, the average satisfaction with the treatment is 3.38 out of 4 with a standard deviation of 0.5, and based on the patient's assessment, it is 3.2 out of 4 with a standard deviation of 0.71, which is equivalent to more than 76% of the effectiveness of Nd:YAG 1064 nm laser in the treatment of telangiectatic veins. The pain during laser treatment was recorded as 6.27 with a standard deviation of 2.64 based on The VAS Scale.
Conclusion: Our experience has demonstrated that the long-pulsed 1064 nm Nd:YAG laser is an effective, reliable, safe method in the treatment of telangiectatic and reticular veins of the lower limbs with minimal side effects and complications.
Zahrabeigom Moosavi, Shayan Zamani,
Volume 14, Issue 4 (2-2024)
Abstract
Itch is one of the commonest complaints of patients of patients in skin clinics. Chronic itch is defined itch lasting more than 6 weeks, which suffers the patients and significantly reduces their quality of life. In this review, we explain pathogenesis and available treatments as a whole. In addition, we summarize pathogenesis and therapeutic options of some common conditions with chronic pruritus, except eczema, such as chronic kidney disease, cholestasis.
Ala Ehsani, Amirhoushang Ehsani, Zahra Razavi, Mina Koohian Mohammadabadi, Mahshidsadat Ansari, Zeynab Aryanian, Pedram Nourmohammadpour, Amirmohammad Almasi, Amirhossein Rahimnia,
Volume 15, Issue 2 (8-2024)
Abstract
Background and aim: As the use of botulinum toxin to treat glabellar lines increases, particularly in Iran, where foreign products (e.g. Dysport) are relatively expensive, it becomes important to compare the efficacy, side effects, and duration of action of two locally produced botulinum toxin brands, Masport® and Dyston®. This study seeks to assess and compare the treatment results of these two medications.
Methods: In this cross-sectional, descriptive, retrospective study, the medical records of 81 patients who visited Razi Dermatology Hospital for the treatment of moderate to severe glabellar lines were reviewed. Data related to patient satisfaction, duration of action, and side effects of Masport® and Dyston® botulinum toxin were collected and analyzed via a questionnaire.
Results: The mean satisfaction score was 7 for the Dyston® group and 7.7 for the Masport® group, with no statistically significant difference between the two groups (P=0.142). Additionally, the mean duration of action was 3.5 months for Dyston® and 3.8 months for Masport®, with no significant difference observed. Headache was the most common side effect reported, with no other major adverse events noted. Furthermore, there was no statistically significant difference in the incidence of side effects between the two groups.
Conclusion: The findings of this study indicate that both Dyston® and Masport® have similar efficacy and safety profiles. The choice between them can be primarily based on cost and patient or physician preference rather than any significant therapeutic differences. Larger studies are recommended to further validate these findings.
Ala Ehsani, Seyedamirmohamad Rezaei Majd, Amirhoushang Ehsani, Pedram Nourmohammadpour, Mina Koohian Mohammadabadi, Zahra Razavi, Mahshid-Ol-Sadat Ansari, Reyhaneh Seyf, Amirhossein Rahimnia,
Volume 15, Issue 3 (11-2024)
Abstract
Background and aim: Pityriasis lichenoides (PL) is a rare papulosquamous disorder with an unknown etiology. Due to limited recent studies on this subject, the present research was conducted to describe the clinical manifestations and treatment course of these patients.
Methods: This retrospective cross-sectional study (2019-2023) was conducted on patients diagnosed with PL at Razi Dermatology Hospital, Tehran University of Medical Sciences, Iran confirmed by biopsy of skin lesions. Basic information was obtained from hospital records, and treatment follow-up was gathered from medical files and phone interviews with patients. Data were analyzed using R software, with a P<0.05 considered statistically significant.
Results: A total of 147 patients were evaluated. No significant difference was found between genders (P=0.358). The predominant subtype was PLC (91.8%), with a mean age of onset of 29.79 ± 18.73 years. The most common type of skin lesion was papules (48.4%), and generalized body involvement was the most frequent manifestation, observed in 58 patients (32.4%). The most commonly used treatment was topical corticosteroids, administered to 86 patients (52.4%). The average duration from onset to full recovery was 160.80±221.40 days. A total of 45 patients (30.6%) reported recurrent episodes of the disease. No significant association was found between treatment efficacy and gender (P=0.620), underlying conditions (P=0.293), or age (P=0.876).
Conclusion: Given the limited clinical data on patients with pityriasis lichenoides, establishing an electronic database and a national registry system for this condition is recommended.
Shahin Hamzelou, Fatemeh Jafari, Maryam Nasimi,
Volume 15, Issue 4 (2-2025)
Abstract
Background and aim: In the severe cases psoriasis, there is a need for biologic treatments which target the immunological responses contributing to the disease pathophysiology. There is no study in definite indications for the treatment choice and the time to start the biologic treatment in Iranian psoriasis patients.
Methods: We designed a cross-sectional study and evaluated all psoriasis patients who had received biologic treatment. After determining the patients who were eligible to participate in the study, their records were studied and analyzed.
Results: 50 patients with the mean age of 42.86 (SD=14.33) participated in the study. Twenty-five patients had received phototherapy for the treatment of psoriasis. All patients had received topical agents and 47 (94%) had received systemic treatment. Adalimumab was the most common biologic treatment used for the treatment of psoriasis patients (74%). 24% of patients had received Infliximab and 4% had received Etanercept.
Conclusion: 50 patients with the mean age of 42.86 (SD=14.33) participated in the study. Twenty-five patients had received phototherapy for the treatment of psoriasis. All patients had received topical agents and 47 (94%) had received systemic treatment. Adalimumab was the most common biologic treatment used for the treatment of psoriasis patients (74%). 24% of patients had received Infliximab and 4% had received Etanercept.
