Showing 18 results for Acne
Dariush Akbari, Narges Hosseinpour,
Volume 1, Issue 3 (9-2010)
Abstract
Background and Aim: Hirsutism is defined as the presence of terminal hairs in androgen dependent areas in women. It is a common clinical condition and affects 5% to 10% of women of reproductive age. The aim of this study was to determine the clinical features and etiologic factors of hirsutism in premenopausal women.
Methods: In this cross-sectional study, 200 premenopausal women with hirsutism who were admitted at our dermatologic clinic during a 2-year period were nivestigated. After a careful history and physical examination, a transabdominal ultrasonography of the ovaries and laboratory evaluation including early morning total testosterone, prolactin, dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogestron in all patients and thyroid stimulating hormone (TSH) in 10 patients were performed.
Results: Polycystic ovary syndrome (PCOS) was the most common cause of the hirsutism (54.5%) followed by idiopathic hirsutism (40%). Other causes of hirsutism were prolactinoma (2%), hypothyroidism (1%) and drugs intake (2.5%). Hirsutism was mild in 109 patients (54.5%), moderate in 85 patients (42.5%) and severe in 6 patients (3%). Family history of hirsutism was present in 105 (52.5%) patients. Clinical conditions associated with hirsutism were: acne (52.5%), menstrual irregularity (35%), androgenetic alopecia (15%), acanthosis negricans (7.5%) and obesity (37.5%).
Conclusion: PCOS and idiopathic hirsutism are the most common cause of the hirsutism in premenopausal women. A detailed history and physical exam often provide enough information to determine the etiology of hirsutism.
Tahereh Naderi, Marzieh Akbarzadeh, Mohammad Hossein Dabagh Manesh, Hamidreza Tabatabaei, Zahra Zareh,
Volume 2, Issue 2 (6-2011)
Abstract
Background and Aim: Adolescents with polycystic ovary syndrome concern about weight gain, menstrual irregularities, acne and hirsutism. The aim of this study was to determine the frequency of facial and trunkal lesions of acne in 14- to 18-year-old high school students with polycystic ovary syndrome in Shiraz in 2009.
Methods: In this cross-sectional study, 3189 14- to 18-year-old female students were enrolled. Using questionnaires, data on personal information, clinical features and laboratory findings of hyperandrogenism and results of ultrasound examination were collected. Severity of acne was classified as mild, moderate and severe, based on the type and number of the lesions. Chi-squared and independent t tests were used for comparing proportions and means, respectively.
Results: The prevalence of severe acne was 5%. Mean total testosterone in individuals with severe acne was higher in comparison with those without acne. Severity of facial and trunkal acne were associated with polycystic ovaries (P<0.05). Mean level of luteinizing hormone (LH) was higher in those without acne than in those with severe acne (P >0.05).
Conclusion: Associations between severity of facial and trunkal acne lesions and polycystic ovaries were observed. Considering the undesirbale effects of acne on quality of life, hormonal screening and ultrasound examination in girls with moderate acne is recommended.
Pouran Layegh, Hesamolddin Saeedian, Mahnaz Banihashemei, Habibollah Esmaeilee, Akram Momenzadeh,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: Oral isotretinoin is the only drug that is effective on almost all factors involved in the pathogenesis of acne. Although several studies have been conducted on side effects of this drug, few studies have been conducted on Iranian patients. The aim of this study was to evaluate common clinical and laboratory side effects of this drug in patients with nodulo-cystic acne in Mashhad, Iran.Methods: One-hundred nodulo-cystic acne patients without previous history of hematologic, renal or hepatic diseases and with negative pregnancy tests (in female patients) were enrolled to this study. Patients were treated with standard regimen of oral isotretinoin with a cumulative dose of 120 mg/kg for a treatment course. Demographic data of each patient and results of baseline laboratory tests including serum lipids profile, liver function tests and cell blood counts were recorded.Laboratory tests and the clinical side effects were assessed every two months.
Results: All patients completed treatment course. The most common side effects were cheilitis (87%), dry skin (71%), various types of dermatitis (37%), epistaxis (21%), arthralgias and myalgias (21%). All side effects were mild and treatment discontinuation was not necessary in any case. Although some changes were observed in serum lipid profiles and liver function tests, but these changes were within normal range.
Conclusion: Treatment with oral isotretinoinis associated with few complications in patients with nodulo-cystic acne, but the possibility of serious side effects should always be considered.
Amir Hooshang Ehsani, Mahboobeh Sadat Hosseyni, Kambiz Kamyab, Masoomeh Rohani Nasab, Amir Reza Hanifnia, Pejman Mobasher, ,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Cicatricial alopecia is characterized
by permanent destruction of the pilosebaceous unit, leading to
irreversible hair loss, and has primary and secondary types. Primary type,
based on predominant inflammatory infiltration in histology, is divided to
neutrophilic, lymphocytic and mix types. Decalvans folliculitis, dissecting cellulitis and
acne keloidalis are 3 subtypes of neutrophilic group. In this study frequency
of each subtype and the distribution of age, gender and duration of disease
have been reviewed.
Methods: This retrospective study was performed on patients
with clinical diagnosis of cicatricial alopecia and histologic confirmation
referred to Razi hospital in Tehran in 2005-2009.
Results: Of 135 patients with mean (mean±SD) age of 32±10.6
years, 71.9% were male and 28.1% were female. The diagnoses included decalvans
folliulitis (72.6%) with mean age of 31.89 years, dissecting cellulitis (25.0%)
with mean age of 32.4 years and acne keloidalis (1.5%) with mean age of 52
years. The mean duration of disease was 4.2±3.9 years (4.08 years in male and
4.7 years in female). The mean duration of disease in decalvans folliulitis was
4.7, in dissecting cellulitis was 1.9 and in acne keloidalis was 17.5 years.
Conclusion:
Neutrophilic scarring alopecia is more common in men and in the third decade of
age and the most common type is decalvans folliulitis.
Hamideh Herizchi Qadim, Shahla Babaei Nejad, Badrolsadat Rahnama, Morteza Gojazadeh, Masood Sheykhnavasi,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Acne vulgaris is a common disorder of adolescence which may lead to significant cosmetic and psychological problems. Different topical and systemic therapeutic modalities have been used to treat acne vulgaris. This study was designed to compare the efficacy of topical 0.05% isotretinoin gel with 1% clindamycin solution in the treatment of acne vulgaris.
Methods: In this randomized clinical trial, 60 patients with mild to moderate papulopustular acne vulgaris were randomly allocated into two groups of equal sizes. One group was treated with 0.05% isotretinoin gel every night. The other group was treated with 1% clindamycin solution twice daily. Both groups were followed every month for 3 months.
Results: The mean of total lesion count decreased significantly after treatment in comparison with its mean before the treatment in both groups (P<0.001). The mean of acne severity index significantly reduced after treatment in both groups (P<0.001). Satisfaction of patients in clindamycin group was higher (P<0.001).
Conclusion: Decrease in total lesion count and acne severity index in both treatment groups were statistically significant however, considering the minimal complications and satisfaction of patients in clindamycin group, 1% solution of clindamycin may be recommended in the treatment of papulopustular of acne vulgaris.
Farhad Handjani, Md, Maryam Sadat Sadati, Md, Ali Firoozabadi, Md, Vala Rezaei, Sara Akramzadeh,
Volume 4, Issue 2 (6-2013)
Abstract
Background and Aim: Acne is one of the most common skin diseases. One of the best treatments is systemic isotretinoin. Some studies link its use with depression, psychiatric problems and suicide, but it is still a matter of debate. So, this study was designed to determine the frequency of depression in acne patients, treated with isotretinoin.
Methods: Fifty-nine acne patients between 16 -30 years old were included. The patients received 0.5-1 mg/kg/day isotretinoin for 16 weeks. At the beginning and at the end of study, the Beck questionnaire was completed by the patients and the results were analyzed.
Results: The mean score of the Beck questionnaire was 13.19 at the beginning of the study and 14.80 after 4 months of treatment with isotretinoin (P=0.0001).
Conclusion: The results of this study showed that isotretinoin may have a small, but still noticeable increase in depression scores of acne patients. However, it is important to consider that various other parameters, such as individual’s psychological status at the time of completing the questionnaire, might influence the results. So, further studies with more patients and longer durations, and the use of other pertinent questionnaires, are recommended.
Ameneh Yazdanfar, Mohammadreza Ahmadpanah, Zohre Kheradmand,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Vitiligo and acne are common chronic skin diseases with cosmetic impacts affecting various aspects of quality of life. This research was done to study the quality of life in these patients and their related factors.
Methods: This cross-sectinal study was carried out on 132 patients with vitiligo and 136 patients with acne. The patients were asked to answer questionnaires including questions about their demographic and clinical information as well as questionnaire of Dermatology Life Quality Index (DLQI). SpSS version 16 was used to statistically describe and test the data.
Results: The mean±standard deviation (SD) ages of patients with vitiligo and acne, were 22.8±5.7 and 28.9±11.5 years, respectively. The proportions of female patients with vitiligo and acne were 54.5% and 83.8%, respectively. Patients were matched for age and gender. There was no statically significant differrence between the mean DLQI score and age, martial status, occupation, residence, education, age of onset of disease in neither group. Patients with more chronic vitiligo experienced significantly impaired quality of life (P=0.008). A statistically differrence was found between mean DLQI scores and clinical forms of vitiligo. The mean scores of patients with generalized type was higher than those with localized forms (P=0.032). Patients with severe acne experienced significantly impaired quality of life (P=0.002). The mean DLQI scores in vitiligo and acne were 6.75 and 7.05, respectively, but this differrence was not statistically significant (P=0.08). A statistically significant difference was found in two subgroup: in symptoms and feelings (P=0.002) and interpersonal relationships (P=0.02).
Conclusion: The quality of lifves of patients were affecteded by the type of disease, its severity and its duration in both groups.
Ghasem Rahmatpour Rokni, Adele Bahar, Mahnaz Sharifian, Seyed Naser Emadi Chashmi, Amir Hosein Kianezhad, Mohammad Raisian,
Volume 7, Issue 1 (4-2016)
Abstract
Background and Aim: Hirsutism is defined as the presence of terminal hairs in androgen dependent areas like upper lip, cheeks, chin, breasts, lower area of abdomen and thigh in women. The aim of this study was to determine the etiologic factors and clinical features of hirsutism in premenopausal women.
Methods: In this cross-sectional study, 180 premenopausal women with hirsutism who were admitted at a referral dermatologic clinic in a 1-year period were investigated. After taking full medical history and performing physical examinations, a transabdominal ultrasonography of the ovaries, and laboratory evaluation including early morning total and free serum testosterone, prolactin, dehydroepiandrosterone sulfate, FSH, LH and 17-hydroxyprogestron in all patients were performed.
Results: The most common causes of hirsutism were idiopathic (51.1%), polycystic ovarian syndrome (37.7%), hyperprolactinemia (4.4%), adrenal hyperplasia (3.8%), and drug-induced (2.8%). Hirsutism was mild in 93 (51.6%) patients, moderate in 78 (43.3%) patients and severe in 9 (5%) patients. Family history of hirsutism was present in 100 patients. Clinical conditions associated with hirsutism were: acne (58.3%), obesity (55.5%), menstrual irregularity (38.8%), androgenic alopecia (17.7%) and acanthosis negricans (8.4%).
Conclusion: Idiopathic hirsutism and polycystic ovary syndrome were the most common causes of the hirsutism in premenopausal women. Obesity also had a significant role in hirsutism occurrence.
Saman Mohammadi, Payam Khazaeli, Simin Shamsi Meymandi, Mahin Aflatoonian, Maryam Khalili Meybodi, Niloofar Mehrolhasani, Azadeh Mohebi, Yuns Jahani,
Volume 7, Issue 2 (7-2016)
Abstract
Background and Aim: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Retinoids are used as the first line therapy in acne. Systemic absorption and skin irritation including redness, pruritus and exfoliation are some of their side effects. In this study we compared the efficacy of isotretinoin 0.05% niosomal gel versus adapalen 0.1% gel in treatment of acne vulgaris.
Methods: In this randomized double blind clinical trial, 144 patients with mild to moderate acne vulgaris aged from 15 to 30 years were enrolled. The patients were randomly allocated into two groups of A, whom were treated with isotretinoin 0.05% niosomal gel and B whom were treated with adapalen 0.1% gel. The patients were evaluated for clinical reponse, decrease in the number of inflammatory and non-inflammatory lesions and side effects after 2, 4, 8, and 12 weeks of the initiation of treatment.
Results: At the end of the study the clinical responses of comedones and inflammatory lesions in isotretinoin 0.05% niosomal gel group were 68% and 79%, in comparison with 65% and 76% in the adapalen gel group, respectively. The differences were not statistically significant. At the end of the treatment period more decrease in number of inflammatory and non-inflammatory lesions were seen in group A patients (niosomal isotretinoin) than group B (adapalen 0.1% gel) (P<0.001). Also side effect of skin redness was found more in group B (P<0.001).
Conclusion: Isotretinoin 0.05% niosomal gel has less side effects and more efficacy in the treatment of mild to moderate acne vulgaris in comparison with adapalen 0.1% gel.
Amir Houshang Ehsani, Hossein Mortazavi, Pedram Noormohammadpour, Arghavan Azizpour, Sara Rostami, Maryam Nasimi,
Volume 7, Issue 2 (7-2016)
Abstract
Background and Aim: Acne vulgaris is a common skin disorder. This study was conducted to evaluate the impact of Ramadan fasting on acne healing in patients admitted to the dermatology clinic, Razi Hospital, Tehran.
Methods: In this prospective cohort study, 10 fasting persons (9 women and 1 man) and 10 non-fasting persons (9 women and 1 man) with acne were studied. Their baseline acne severities were recorded and acne improvement was evaluated in both groups after Ramadan month.
Results: Acne improvement was 71% in fasting persons and 49% in non-fasting persons. Improvement in fasting persons i.e. was 1.4 times of non-fasting ones (P=0.158). However, no significant statistical difference was detected. Also, it was determined that improvement was different according to acne grading. Improvement in acne lesions in patients with grade 2 severity was 100%, in those with grade 3 acne was 78%, and in patients with grade 4 acne was 35 % (P=0.025). But in non-fasting patients there was not a statistical difference between acne severity and improvement rate. Furthermore in patients younger than 24, improvement rate of acne was 1.6 fold more than non-fasting persons and in patients older than 24, this ratio was 1.3 (P=0.011).
Conclusion: This study did not show any statistically significant difference in acne improvement between who were fasting and who were not during Ramadan. Studies with larger sample size are recommended.
Nazi Saljoughi, Roghieh Jebraili, Setareh Tehrani, Masoumeh Yarjanli, Sepideh Tehrani, Forugh Ghaedi,
Volume 7, Issue 4 (1-2017)
Abstract
Background and Aim: Acne vulgaris is a common skin disease and oral isotretinoin is the only treatment that is dramatically effective on its severe type The aim of this study was to evaluate the effects of oral Isotretinoin on the level of sex hormones and menstrual cycle in female patients with severe acne.
Methods: In this before and after treatment study, 50 patients with severe acne vulgaris whom were referred to the dermatology clinic of Amir-Almomenin Hospital in Tehran in 2015 and 2016, were recruited. The inclusion criteria were female gender, age between 18 to 50 years, and having severe acne. Exclusion criteria were: pregnancy, lactating, and suffering from other diseases which could confound the study results. The prescribed dose of the oral isotretinoin was 0.5 mg/kg/day for three months. Before initiation of treatment and after three months of treatment serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, and total and free testosterone were measured and compared.
Results: The mean ± standard deviation (SD) age of the patients was 26.0 ± 7.1 years, and 10% of them had polycystic ovary syndrome (PCOs). After taking isotretinoin, 33 (66%) of patients had no change in their menstrual periods, while 3 (6%) had oligomenorrhea, 4 (8%) had amenorrhea, and 10 (20%) had dysmenorrhea. After treatment, mean serum LH levels significantly increased (P=0.001), but FSH, estradiol, and total and free testosterone serum levels did not change statistically (P>0.05).
Conclusion: This study showed that oral isotretinoin can increase the level of serum LH and cause changes in menstrual cycles.
Sepideh Rahmani, Gholamreza Askari, Mehdi Sadeghian, Motahareh Heidari,
Volume 8, Issue 2 (7-2017)
Abstract
Background and Aim: Acne is one of the most common diseases among young individuals. Controversial findings are reported about the effect of glycemic index (GI) and glycemic load (GL) of the diet on acne vulgaris. The aim of this study was to investigate the effect of GI and GL of diet on severity of acne.
Methods: All relevant studies on effects of GI or GL on acne published up to December 2016 were collected using PubMed, Google Scholar, Science direct, Ovid and Cochrane library.
Results: Of 714 articles in our initial research, 6 interventional and 3 case-control studies were included.
Case-control studies revealed that patients with acne vulgaris consumed diets with a higher GI rather than control group. Intervention with a low GI diet reduced lesion counts and improved the severity of acne as well as insulin sensitivity compared with those under high GI diet.
Conclusion: Overall, a diet with low GI and GL could improve acne severity and inflammatory lesions.
Marjan Oryan, Mohammad Hosein Hakimi Meybodi, Mohammad Ebrahimzadeh Ardekani, Bahman Kiani,
Volume 9, Issue 2 (7-2018)
Abstract
Background and Aim: The use of medicinal herbs for the treatment of skin disease, such as acne, has a long history. The extract of Pistaca atlantica is used to treat various diseases. This study was designed to evaluate the short-term efficacy and safety of Pistaca atlantica extract for the treatment of mild to moderate acne.
Methods: This clinical trial was performed on 60 patients with mild to moderate acne, who where randomly divided into two groups. After obtaining informed consent, volunteers in the case group received a topical extract of 15% Pistaca Atlantica once daily for 6 weeks. In the control group, placebo was given in the same way. Patients were evaluated for the number of lesions at the beginning, and 3 and 6 weeks after treatment.
Results: At the end of study, the mean reduction in lesions was 59.93% in the Pistaca atlantica group and -11.46% in the control group. Also Skin softness and lucidity were observed in the Pistaca atlantica group.
Conclusion: This clinical study showed that topical treatment with Pistaca atlantica extract can be recommended to improve mild to moderate acne. However, a longer study with larger sample size is needed to achieve a comprehensive evaluation of the efficacy and safety of this plant.
Mohamad Shahidi Dadras, Hamideh Moravej, Ayda Bahman, Rezvan Aghili, Atefeh Talebi, Fahimeh Abdollahi Majd,
Volume 11, Issue 2 (7-2020)
Abstract
Background and Aim: Acne vulgaris is one of the most common skin diseases in adolescents and young adults. Although acne do not physically disable the patient, it can cause significant psychological morbidities. The disease etiology is not fully understood; however, there are several factors involved in the pathogenesis. The aim of this study is to investigate the seasonal variation of acne vulgaris in patients referred to skin clinic of Shohaday-e-Tajrish Hospital in Tehran in 2017.
Methods: This study was a cross-sectional study in patients diagnosed with acne vulgaris by a dermatologist. One-hundred three eligible patients were enrolled in the study. The severity of acne was graded as mild, moderate or severe. In addition to the demographic data, information on the acne severity and changes in the acne severity in summer and winter had been recorded.
Results: The average age of 103 acne patients was 24.68±6.77 years. Sixty-eight patients were female and 35 cases were male. Fifteen (14.6%) patients had mild acne, 55 (53.4%) cases had moderate acne and 33 (32%) subjects had severe disease. In the summer, symptoms improved in 34 (33%) patients, worsened in 18 (17.5%) patients, and remained unchanged in 51 (49.5%) cases. In winter, symptoms improved in 15 (14.6%) patients, worsened in 37 (35.9%) patients, and remained unchanged in 51 (49.5%) patients (P=0.001). There was no significant relationship between changes in the severity of acne in winter or summer with age, age of the disease onset or duration or severity of acne (P>0.05).
Conclusion: In the present study, the number of patients with acne exacerbation in winter was significantly higher than that in summer. This may highlight the important role of winter in increasing the acne severity; however, more comprehensive studies with more sample sizes are still needed in different geographical areas.
Sina Khanali, Alirezaei Pedram , Jalal Poorolajal,
Volume 11, Issue 4 (1-2021)
Abstract
Background and Aim: Atrophic scars constitute a common complication of acne and various methods have been proposed for their treatment. This study aims at comparing the efficacy of fractional CO2 laser with microneedling in the management of atrophic acne scars.
Methods: Patients with atrophic acne scars presenting to dermatology clinic of Hamadan’s Sina hospital between March 2016 and March 2018 were included in the study. Every 3 weeks, each patient received fractional CO2 laser on one side of the face and microneedling on the other side, for a total of 4 sessions. Patient’s satisfaction and the severity of scars (based on Goodman and Baron’s scar scale) were assessed 1, 2 and 6 months thereafter.
Results: Overall, 24 participants were included. Prior to intervention, no significant difference was observed between groups in terms of mean scar score (P=0.726). At 1, 2 and 6month follow-up visits, the scar score of the side treated with laser was significantly lower than the microneedling side (P for 1, 2 and 6month follow-up visits: 0.033, 0.008 and 0.014). No significant difference was observed between groups in terms of patient’s satisfaction (P for 1, 2 and 6 month follow-up visits: 0.589, 0.469 and 0.840). The most prevalent side effect was erythema in 3 patients treated with laser. Due to low prevalence, statistical analysis of side effects between groups was impossible.
Conclusion: Compared to microneedling, fractional CO
2 laser was more effective in reducing the scar score of patients. The prevalence of side effects in both treatments were low.
Mohamad Ahmadpanah, Amir Amini, Zahra Cheraghi, Pedram Alirezaei,
Volume 12, Issue 1 (5-2021)
Abstract
Background and Aim: Acne vulgaris is one of the most common skin disorders, affecting more than eighty percent of individuals around puberty. Because of the adverse effects on the patient’s appearance, the disease may have detrimental psychological impacts such as low self-esteem and social isolation. The aim of the present study was to evaluate factors affecting self-esteem in patients with acne vulgaris in Hamadan.
Methods: Patients with acne vulgaris referred to the dermatology clinic of Hamadan’s Sina Hospital (as the case group), and their healthy accompanying persons (as the control group) were included in the study. After obtaining written informed consent, demographic dat
a were recorded and participants were asked to fill out a questionnaire. To assess the severity of acne, Global Acne Grading System (GAGS) was used. In addition, Coopersmith Inventory was applied to measure the self-esteem of the participants. In data were analyzed using STATA 14.0 software.
Results: Overall, 184 patients with acne and 177 controls were included in this study. The mean age of patients and controls was 17.89+3.13 and 17.72+2.94, respectively. Independent samples t-test showed that the mean Self-Esteem Index of patients was significantly lower than controls (32.04+8.29 vs. 34.85+7.73, P<0.001). The severity of acne was inversely correlated with self-esteem; one score increase in GAGS would result in 0.1 unit decrease in self-esteem index (P<0.001).
Conclusion: Acne vulgaris is associated with low self-esteem and the severity of acne is inversely correlated with self-esteem level.
Maryam Ghiasi, Mahshidsadat Ansari, Maryam Nasimi, Farnaz Pourrajab,
Volume 12, Issue 2 (8-2021)
Abstract
Background and Aim: Atopic dermatitis is a chronic inflammatory disease that is caused by an inflammatory process stimulated by Th2 cells. Acne vulgaris is a chronic inflammatory skin disease. It is associated with an increase in sebum secretion, unusual pilosebaceous keratinization and an increased inflammatory immune response. Propionibacterium acne can induce IL-17 production and Th1/Th17 response. The present study was designed to determine the prevalence of atopic dermatitis in patients with acne.
Methods: In this case-control study, the case group consisted of 75 individuals with acne and the control group consisted of 75 individuals without acne matched in age and gender. Both groups were interviewed for atopic dermatitis, asthma and allergic rhinitis symptoms in the past and present.
Results: Prevalence of atopic dermatitis at present in patients who had acne was significantly lower than those who did not have acne. There was no significant difference between case and control groups in frequency of atopic dermatitis in the past and frequency of asthma and allergic rhinitis in the present and past time.
Conclusion: The inverse relationship between prevalence of acne and atopic dermatitis can be related to activation of different immune responses (Th1 versus Th2), but more studies should be done to confirm this relationship.
Hasan Adalatkhah, Shabnam Fahim, Sohrab Iranpour, Zahra Mohebbi,
Volume 15, Issue 4 (2-2025)
Abstract
Background and Aim: Melasma is an acquired, chronic, and recurrent pigmentation disorder that usually affects sun-exposed skin areas. SAHA syndrome is also an acronym for four words: seborrhea, acne, hirsutism, and androgenic alopecia. Given the association of melasma with some components of SAHA syndrome, such as acne and hirsutism, this study was conducted to determine the relationship between melasma and SAHA syndrome.
Methods: This case-control study was conducted on 75 women with melasma as the case group and 75 women without melasma as the control group. Data were collected in the form of a questionnaire consisting of 28 questions and analyzed.
Results: In the case group, 32% had hirsutism and 70.7% had acne. In the control group, 10.7% had hirsutism and 26.7% had acne. There was a significant association between factors (history of melasma in first-degree relatives, history of hirsutism in first-degree relatives, acne, alopecia) and melasma. Among the case group, 5.3% had SAHA syndrome.
Conclusion: Considering that androgenic disorders are implicated in the etiology of SAHA syndrome and melasma, it seems that melasma lesions are more common in patients with SAHA syndrome.
