Showing 8 results for Basal Cell Carcinoma
Zahra Safaei Naraghi, Mahdi Hadisi, Firouz Amani, Soulmaz Fathi,
Volume 1, Issue 3 (9-2010)
Abstract
Background and Aim: Tumor angiogenesis is essential for tumor growth and appears to play an importating role both in invasive growth and metastasis. Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. Basal cell carcinoma generally shows a relatively benign course in contrast to squamous cell carcinoma .This study investigates whether the behavior of these tumors could be explained by differences in their angiogenesis pattern.
Methods: Vessel counts were made of blood vessels in stroma and the body of 50 variants of BCC of skin samples including: nodular, micronodular, sclerosing and superficial, both after H&E and immunohistochemical staining for CD31 and CD34 markers.
Results: The body vessel counts of invasive variants (sclerosing & micronodular) differed significantly from the counts of noninvasive variants (nodular and superficial) using both CD31 & CD34 markers. The stromal vessel counts compared between invasive and noninvasive variants showed no significantly difference using CD31 & CD34 markers, respectively.
Conclusion: The invasive growth pattern of BCC variants correlated with the microvascular density and according to results, vessel counts of the body play a more important role.
Ameneh Yazdanfar, Elham Ghasemi,
Volume 2, Issue 2 (6-2011)
Abstract
Background and Aim: Skin cancers are one of the most common malignancies in the world and create a high rate of morbidity but low rate of mortality with the exception of malignant melanoma that has a high mortality rate. In recent decades, incidence of skin cancer has been increased. The most important risk factors are sunlight and skin type. The aim of this study was to evaluate the frequency of skin cancers in patients who were admitted to Sina Hospital of Hamedan during a 17-year period.
Methods: In this cross-sectional study, 951 patients with different types of skin cancer, entered in the study. For each patient, data related to age, gender, location, occupation, pathologic type of cancer and site of skin involvement, were collected.
Results: The mean age (mean±standard deviation) of patients was 61.6±15.3 years (2-100 yrs) and most of them (67.2%) were males and workers (%38). The most common pathologic types of skin cancer were basal cell carcinoma (BCC) (59%) and squamous cell carcinoma (SCC) (29%). The most frequent site of tumor expression was face (61.2%) and the least frequent involved site was genitalia (0.4%).
Conclusion: This study showed that skin cancer is more common in males, old patients and workers. It was more common on the face. Screening program for detection of this disease at an earlier stage of elderly men especially in sun exposed occupations is recommended.
Hossein Kavoussi, Mansour Rezaei, Danyal Isapour, Seyyed Reza Seyyed Mohammad Doulabi,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Basal cell carcinoma (BCC) is the most common type of malignancy that rarely causes death but results in cosmetic problems and is associated with high treatment cost. Clinical characteristics of this cancer are related to the host and environmental factors. Theses factors are specific for each area and may change over the time. The aim of this study was to find clinical characteristics of BCC in Kermanshah city.
Methods: This cross-sectional study was done on 119 histopathologically documented BCC cases in Haj Dayi skin clinic in Kermanshah in 2009. Demographic data of patients and characteristics of the lesions including their number, location, size and clinical type were recorded. Data were analyzed using ANOVA and chi squared tests.
Results: The patients had a total number of 171 BCC lesions. Nodular type encompassed 158 (92.4%) lesions and was the most common clinical form. Pigmented subtype included one third of lesions and was significantly more common in male patients with moderate brown skin and following radiotherapy (P<0.05). The nose was the most common area of involvement and actinic keratosis was the most common associated skin lesion.
Conclusion: In this study, the most common clinical and pathological type of BCC was nodular type. It was observed in old patients, those with outdoor jobs and was associated with actinic keratosis. Educational and screening programs for prevention, early detection and diagnosis, and appropriate treatment for high-risk individuals are suggested.
Akram Ansar, Maryam Tamimi, Leyla Mousavi, Sa'adat Torabiyan,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Skin basal cell carcinoma (BCC) is the most common cancer in human beings. Prevalence of this tumor has increased over the past decades. The standard treatment is complete excision, however some risks for recurrence still exist. The aim of this study was to determine the frequency of margin involvement in skin BCC as well as to investigate the demographic characteristics of the patients.
Methods: This study was conducted from April 2011 to April 2012 on the patients who had skin lesions suspected for BCC. The patients were undergone elliptical excision surgeries for removing their suspected lesions with 5-millimeter margins of clinically normal skin in Farchian Hospital, Hamadan, Iran. Following data were collected and recorded: age, sex, anatomical location, duration of the disease, primary clinical diagnosis, histopathologic type, and margin involvement.
Results: In total, 125 lesions from 115 patients were investigated (70 males, 45 females). The range of the ages of the patients were from 32 to 93 years, with a mean of 64.6 years. The most common histopathological type was nodular type (61.0%). Twenty percent of the excised lesions showed margin involvement. Risk factors for incomplete excision were older age and anatomical locations (ears and peri-ocular lesions). There was no statistically significant differences between sex, histological type, primary clinical diagnosis, and duration of the disease. In almost all cases, the clinical and histopathological diagnoses were similar.
Conclusion: To avoid repeated surgeries and to reduce the risk of incomplete excision for lesions on high risk locations, particularly in elderly, it is recommended that BCCs be excised with wide margins or Mohs micrographic surgery.
Fatemeh Vandrajabpour, Reza Raoofian, Fatemeh Gholamali, Pedram Noormohammadpour, Morteza Hashemzadeh Chaleshtori, Mina Tabrizi,
Volume 4, Issue 4 (12-2013)
Abstract
Basal cell carcinoma (BCC) is the most common cancer in Iran and in the world and its prevalence may become equivalent to the prevalence of all other cancers combined in the future. The Hedgehog (Hh) signaling pathway has an important role in tumorigenesis of BCC. Mutations in PTCH and Smo molecules of this pathway account for 85% to 95% of sporadic BCCs and also most cases of inherited cases. Currently, several treatment methods exist for this cancer. Mohs surgery and removing the whole tumor with free margins are the most efficient way for metastatic and highly invasive BCCs. According to the latest findings, small inhibitor molecules of the Hh pathway are becoming highlighted in drug production. Vismodegib an inhibitor of Smo, was approved by the Food and Drug Administration in 2012 as a drug for metastatic and highly invasive BCCs. Therefore, strategic targeting of signaling molecules has demonstrated success and holds great potential in medicine.
Robabeh Abedini, Vahide Lajevardi, Azadeh Goodarzi,
Volume 8, Issue 3 (10-2017)
Abstract
Nowadays, in modern medicine, there is a great tendency to use non invasive or less invasive diagnostic and therapeutic methods with high precision and effectiveness. This is also true about diagnosis and treatment of non-melanoma skin cancers (NMSCs), that the prototypes are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) which also considered as the most common human cancers. Therefore, in this review, we present the value and diagnostic features of the dermoscopy (as an emerging and growing non-invasive dermatological evaluation tool) for approaching to NMSC. It is hoped that this study will be an infrastructure for the ever-increasing use of dermoscopy in evaluation of skin cancers, especially NMSCs.
Shahryar Haddadi Abianeh, Moshir Fasihi, Kambiz Kamyab, Alireza Firooz, Mansour Nasiri Kash,
Volume 9, Issue 2 (7-2018)
Abstract
Background and Aim: Preoperative assessment of skin tumors extensions have a potential role to increase the efficiency of surgery and maximal preservation of function and cosmetics in the treatment of invasive types of basal cell carcinoma (BCC).
Methods: A total of 72 patients with BCCs on face were included in the study. Gross maximal width of tumors were documented, and then high frequency ultrasonic (HFUS) maximal width and depth of these lesions were determined. Then conventional surgical excision was done and these margins were determined in pathology lab. The comparison of ultrasonic and pathologic depth, and difference of HFUS and pathologic widths from gross clinical width were done with paired t-test.
Results: The mean depth of BCCs were 3.09 mm (SD= 1.02) in HFUS and 2.86 mm (SD=1.22) in pathology (P=0.1). The mean difference from gross width were 4.05 mm (SD=1.18) in HFUS and 4.26 mm (SD=1.70) in pathology (P=0.09).
Conclusions: High frequency sonography has a good accuracy in detection of width and depth of BCCs of face, especially in tumors smaller than 10 mm, and can help to determine safe margins non-invasively, especially in cosmetic and functional critical areas.
Javad Rahmati, Hojjat Molaei Goorchinghalea, Shahriar Hadady Abianeh,
Volume 11, Issue 2 (7-2020)
Abstract
Introduction: Medial canthus area, as one of most common sites of facial skin cancers, is notified for reconstruction. There are numerous reconstructive options to cover resulted skin defects, which have their own advantages and disadvantages. Here, we decided to present our experience in medial canthal area with amazing result.
Case Report: A 47-year-old man with basal cell carcinoma (BCC) of right medial canthus, without extra involvement, was admitted. Following lesion excision with safe margin, the resulted skin defect in 30 mm diameter was reconstructed with full thickness skin graft from posterior auricular area. Several months later, it was really difficult to find scar or operated skin, as supported by complete patient`s satisfaction.
Conclusion: The space between eyes has unbelievable aesthetic and social importance. Any added scar or incision to this area is always challenging. It seems full thickness skin graft - if harvested from proper donor site - can be acceptable in long term aesthetic outcome compared to other reconstructive options.
