Alireza Firooz, Ali Rajabi Estarabadi, Hamed Zartab,
Volume 3, Issue 4 (12-2012)
Abstract
Skin is the largest organ of the integumentary system with multiples important functions. Due to its complex structure, the permeability skin status can be modified by different external and internal factors such as chemical and physical stresses, and several skin and systemic diseases. Today, different non-invasive methods are used to assess the skin barrier biophysical properties. The parameters such as transepidermal water loss, stratum corneum hydration, skin surface pH and skin surface lipids is essential for evaluation of the epidermal barrier status. Application of these methods is critical for evaluation of disease treatments, the effectiveness of topically applied drugs and cosmetic products. The aim of this article is to review application of several methods for skin biophysical and biomechanical properties in humans.
Aniseh Samadi, Hasti Ahmadianyazdi, Maryam Ahmadi, Atefeh Naeimifar, Saman Ahmadnasrollahi, Alireza Firooz,
Volume 12, Issue 4 (2-2022)
Abstract
Background and Aim: Although several commercial moisturizers are available in the market, continued role of pharmaceutical compounding have been still felt in dry skin management. This study aimed to evaluate the effect of a two urea- based compounded moisturizers on barrier function, compared to similar commercial product. 15 volunteers (14 females and one male) age 36.15 ±9.55 years old (range 21-56 years old) with non-pathologic dry skin, recruited to the study applied 5% urea containing hydrophilic petrolatum and 10% urea containing hydrophilic petrolatum during two following phases.
Methods: Upper parts of right and left forearms randomly were assigned for twice a day application of commercial or compounded products. Biophysical assessments including trans epidermal water loss (TEWL), skin hydration, friction co efficient, pH and surface lipids, performed before intervention, 1, 4 after single application and at 24 hours and one week twice daily application.
Results: In both phases, commercial and compounded moisturizers showed appropriate and comparable effect on skin barrier function compared to the baseline. However commercial products, led to better improvement in TEWL, 4 hours after single application in both phases (P=0.04). The rate of increase in skin hydration was also significantly higher for commercial emollient, compared to compounding product (57.48±11.23 vs. 50.59±11.42, P=0.01).
Conclusion: Commercial formulation led to higher acceptability and better improvement on skin barrier function after single application, probably due to influence of excipients. Present study did not find sufficient added value for pharmacy product relative to commercial one and suggest to be replaced in similar condition.
