Amirhoushang Ehsani, Pedram Nourmohammdpour, Shima Sayanjali,
Volume 1, Issue 3 (9-2010)
Abstract
Connective tissue nevi are types of hamartoma with increased collagen in which the amounts of elastin may vary. This report introduces an 18-year-old case with various nodular lesions in upper thigh area. Performed biopsy suggested the diagnosis of collagenoma which is a sub-type of connective tissue nevus.
Hasti Ahmadian Yazdi Ahmadian Yazdi, Alireza Firooz, Maryam Movafegh, Faegheh Kazemi, Saman Ahmadnasrollahi, Aniseh Samadi,
Volume 13, Issue 4 (2-2023)
Abstract
Background and Aim: Oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumers. The purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration and roughness.
Methods: It was a 12-week, before-after clinical study, conducted on 20 participants (18 women and two men) aged 44.15±5.36 years with skin type III-IV. Skin elasticity parameters (R0, R2, R5 and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as four weeks after stopping its use (week 16). Participants’ satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.
Results: A significant improvement was detected in R2, R5 and skin friction at week 12 (P<0.041, P<0.012 and P<0.01, respectively). At week 16, the values remained at an increased level, which indicates the stability of the results. The increase of dermis density in week 16 was also significant (P=0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.
Conclusion: The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (11-2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
Azin Ayatollahi,
Volume 16, Issue 2 (7-2025)
Abstract
Human lip aging is one of the natural signs of the body’s aging process, occurring over time due to factors such as a decrease in collagen and elastin, exposure to sunlight, environmental stress, and genetic changes. As time passes, the lips may lose their appearance, and fine lines or deep wrinkles may form around the lips and the upper lip area. These changes can lead to a reduction in lip volume and the loss of their natural shape. Additionally, dryness and chapping of the lips are other issues commonly observed with lip aging. Skin care, the use of moisturizers, and avoiding prolonged sun exposure can help slow down this process.
