Journal of

---

Background and Aim: Curcumin possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. The aim of this study was to develop liposomal formulation of curcumin and evaluate the leishmanial effects of its topical use against L. major in vitro and in vivo.

Methods: Nanoliposomes containing 1, 2 or 3% curumin were prepared by fusion method and characterized for their size, morphology and stability. The in vitro efficacy of liposomal form of Curcumin against promastigotes and amastigotes form of L. major was also evaluated. Moreover, the leishmanial effect of formulations was evaluated in infected BALB/c mice. The lesions were treated topically by different formulations twice a day, for 4 weeks. During this time and 4 weeks after treatment, lesions size was measured every week. The level of splenic parasite burdens was investigated in week 4 after parasite inoculation.

Results: Curcumin showed no leishmanicidal effect against live promasigotes and amastigotes in culture media. There was no significant difference between treated and control animals regarding lesion size and splenic parasite burden.

Conclusion: The results of this study showed that nanoliposomes containing curcumin in topical form has no significant leishmanicidal effect in vitro and in vivo against
L. major.

---

Curcuma zedoaria, an aromatic plant from the ginger family, has gained attention for its medicinal properties. In traditional medicine, Curcuma zedoaria has been used as an anti-inflammatory, antibacterial, antifungal, and analgesic. Recent scientific research has revealed significant benefits of Curcuma zedoaria for skin health. Curcuma zedoaria contains curcumin, a powerful anti-inflammatory compound that can help reduce skin inflammation, redness, and swelling. This makes Curcuma zedoaria a suitable option for treating acne, eczema, and psoriasis. Curcumin in Curcuma zedoaria also possesses strong antioxidant properties that can help protect the skin from damage caused by free radicals. Additionally, curcumin can promote collagen and elastin production, which are essential for wound healing. The antimicrobial properties of curcumin can aid in combating bacteria and fungi that cause skin infections. Curcuma zedoaria also exhibits anticancer properties that can help prevent the growth of skin cancer cells. Therefore, Curcuma zedoaria is a natural and safe plant that can help treat a wide range of skin problems. This review article explores the various benefits of Curcuma zedoaria for the skin.