Maryam Nasimi, Toomaj Shahverdi, Fatemeh Momeni, Vahid Tajari, Faezeh Khorasanizadeh, Martin Kassir,
Volume 16, Issue 4 (2-2026)
Abstract
Background: Dermal filler injections have gained increasing popularity for face augmentation, skin wrinkle treatment, and contouring. Although generally safe, complications may develop following filler administration. Granulomatous formation reactions to dermal fillers are important adverse reactions. Dental procedures are highly recognized to be a trigger for delayed granulomatous reactions at dermal filler field.
Case presentation:
Case 1: A 32-year-old woman presented with erythema, tenderness, and edema 6 months after ultra4 Juvéderm filler injection at left and right nasolabial folds and both lips. One month prior to the appearance of these symptoms, she had undergone dental scaling and polishing. Histopathological results showed granulomatous reaction to dermal filler. The patient was successfully treated with 2 doses of intralesional corticosteroid injection.
Case 2: A 58-year-old woman presented with nodular growths on her left marionette line and right nasolabial fold subsequent to dental scaling and polishing. Two years prior, she had received injections of Ellansé and Lunaphil Volume dermal filler at both nasolabial folds. An ultrasound examination confirmed a granulomatous response to dermal fillers. The symptoms significantly improved after 2 doses of intralesional corticosteroid injection.
Case 3: A 48-year-old woman, developed a tender erythematous induration in the nasolabial folds where she had received Ellansé filler injection 4 years earlier. The symptoms appeared one month after a surgery on buccal area. Ultrasonography revealed granuloma formation. A regimen of systemic and intralesional corticosteroids resulted in a significant improvement of the symptoms.
Conclusion: These cases highlight dental procedures as a clinically shown factor for granulomatous responses following dermal filler injections, including dental and surgical interventions. More research is required to enhance understanding of the mechanisms and risk factors involved.
