Showing 6 results for Dermatophytosis
Seyed Amin Ayetollahi Mosavi, Hossein Safizadeh, Sanaz Hadizadeh,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Dermatophytes are keratinophilic fungi that cause infection in the skin, hair and nails. Dermatophytic infections are one of the important health problems in the world that related to social and economic life of communities.
Methods: This cross-sectional study was conducted on all suspected patients in the medical mycology laboratory of Afzalipoor Faculty in Kerman from March 2007 to March 2011. For each patient after obtaining the detailed history, direct smear, staining and culture on specific media were performed.
Results: Out of 1800 referred cases, 166 patients were positive for dermatophytosis. The highest prevalence of infection was in the under 10 years old (28.31%), men and women were also involved equally. The most common agents of the cutaneous infection were Trichophyton mentagrophytes (45.78%) and T. verrucosum (18.1%). The most common infections were tinea manuum (35.54%), tinea capitis (16.87), and the least common one was tinea faciei (4.82%).
Conclusion: It is necessary to increase the level of community health in order to prevent this dermatophytosis.
Vahide Lajevardi, Md, Fatemeh Gholamali, Md, Kambiz Kamyab, Md, Maede Rayati Damavandi, Md, Tahereh Soori, Md, Azadeh Goodarzi, Md, Zeinab Aryanian, Md,
Volume 4, Issue 2 (6-2013)
Abstract
Ichthyosis is defined as a group of diseases with keratinization disorder and diffuse scaling with highly variable degree of involvement. According to our knowledge, coincidence of ichthyosis and dermatophytosis, which both are very common disorders, is a very rare event. We report a young man with congenital ichthyosis that histological analysis of his skin biopsies and direct smear revealed PAS positive fungi. He had used topical steroids for generalized scaling erythematous patches and plaques for long time.
Efat Khodaeiani, Javad Shokri, Mahdi Amirnia, Afsane Radmehr, Morteza Ghoujazade, Behzad Anoush, Danial Fadaei Fooladi,
Volume 6, Issue 3 (10-2015)
Abstract
Background and Aim: Dermatophytoses are the infections caused by the fungi that are capable to invade and multiply within keratinized tissues such as the skin, hair and nails. Topical azoles are considered the first-line treatment in dermatophytosis, but systemic therapy may also be required in some cases. Fungal skin infections have become more common in recent years, and injudicious use of conventional drugs has led to emergence of resistant species. This study compared the therapeutic effects of topical colloidal silver with topical clotrimazole in the treatment of tinea capitis and tinea corporis.
Methods: In this double blind, non-randomized clinical trial, 40 patients with tinea capitis and tinea corporis were allocated into two groups, receiving either topical colloidal silver or topical clotrimazole, twice daily for at least 4 weeks. Systemic antifungals were also administreerd if needed. The response to treatment (negative KOH smear and resolved symptoms) was compared between the two groups at the end of the treatment period.
Results: The mean response time was 5.26±1.56 (range: 3-8) weeks in colloidal silver receivers and 5.00±2.20 (range: 3-12) weeks in the clotrimazole group (P=0.67). The response rates were 84.2% in the topical colloidal silver group, and 90.0% in the topical clotrimazole group (P=0.66). None of the patients experienced a side effect.
Conclusion: Topical colloidal silver may be as effective and safe as topical clotrimazole in patients with tinea capitis and tinea corporis. Further studies with larger sample sizes are recommended.
Afsarolmoluk Hadadian, Azin Ayatollahi, Akram Miraminmohammadi, Mahshid Shahrzadkavkani, Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi,
Volume 12, Issue 3 (11-2021)
Abstract
Introduction: Dermatophytosis are micro-organisms which can lead to skin diseases. In rare occasions they can have atypical skin manifestations, which could result in delay in diagnosis.
Case Report: A 20-year-old Iranian boy was referred to our center with a 5-month history of circular, symmetrical, itchy crusted skin lesions on his groin. Direct microscopy, culture test and PCR-sequencing of ITS regions of the rDNA gene were conducted and showed T. indotinea as the causative agent. Based on antifungal susceptibility test oral pulse therapy with itraconazole 100 mg twice daily for 1 week combined with topical clotrimazole cream for 1 month was initiated, which cleared the lesions.
Conclusion: This case report is of significance since T. indotinea produces atypical skin lesions, as well as, multidrug resistance to antifungal agents.
Zahrabeigom Moosavi, Alireza Firooz, Mahsa Fattahi,
Volume 12, Issue 4 (2-2022)
Abstract
Introduction: Tinea incognito is a localized skin infection caused by a fungus. Due to the use of corticosteroids, the shape and severity of the lesion are different from the usual skin manifestations by dermatophytes.
Background and Aim: A 39-year-old female with history of erythematous, scaly skin lesions on her hands, buttock, inguinal and both legs for 7 months referred to clinician, who prescribed Calamine-D and hydrocortisone without any treatment and clobetazole was recomended. She self-continued clobetazole. This case highlight the importance of mycological test in case of atypical skin lesions to choose an appropriate treatment and avoiding to spread of drug resistance species.
Methods: Regarding to history of patient, the mycological test (Direct Microscopy and culture) was made. In direct microscopy and culture mycelia of dermatophyte species was seen.
Results: In our case steroid discontinued and she was treated with oral terbinafine 250 mg once a day for 4 weeks in combination with topical clotrimazole cream.
Conclusion: the prescription of topical/oral corticosteroids should still be limited and take a caution until confirmation of diagnosis, particularly since the use of steroids during COVID 19.
Safoura Shakoeinejad,
Volume 14, Issue 4 (2-2024)
Abstract
Background and Aim: In line with the increase in cases of dermatophytosis of the body and dermatophytosis of the groin, the cases of species resistant to antifungal drugs, especially terbinafine, are increasing. The present study was designed to investigate the drug resistance pattern of dermatophyte species isolated from 27 patients referred to Razi Skin Hospital.
Methods: Skin samples of patients were collected from the groin, buttock and body from the active margin of the lesion. Some of the sample was examined under the microscope for the presence of arthroconidia and fungal hyphae. Cultivation on Saburo dextrose agar 2% special medium with chloramphenicol and cyclohexamide was used to determine the primary identity of dermatophyte species, morphological characteristics were used. To accurately identify trichophytons isolated from the skin of patients by (molecular) genotyping method, ITS1 and ITS4 primers were used. Universal primers) were used. Microdilution broth drug sensitivity test was performed according to M38-3rd ed - CLSI protocol for dermatophyte isolates to terbinafine, itraconazole, fluconazole and voriconazole.
Results: 25 patients were infected with Trichophyton indotinae. 2 patients were infected with Trichophyton interdigitale. In the present study, 4.27 (14.81%) of the patients had antifungal resistance (1 μg/ml≤the minimum concentration of fungal growth inhibition for terbinafine).
Conclusion: Failure to perform mycological examinations before initiating treatment can result in misdiagnosis. Do not use the antifungal susceptibility test lead to challenging to manage treatment-refractory cases. inadequate and inappropriate treatment combinations can increase the number of resistant species worldwide.
