Showing 9 results for Diabetes
Mansour Nassiri-Kashani, Shahab Babakoohi, Ali Kazerouni-Timsar,
Volume 1, Issue 3 (9-2010)
Abstract
This case report introduces a 28-year-old male patient with morphea profunda, peripheral sensory motor nerve involvement, insulin dependent diabetes mellitus and hypothyroidism as an unusual presentation of deep morphea who dramatically responded to prednisolone and metothrexate after 4 months of treatment.
Akram Ansar, Mahmoud Farshchian, Seyed Mostafa Ghasemzadeh,
Volume 2, Issue 2 (6-2011)
Abstract
Background and Aim: Lichen planus (LP) is a cutaneous disease characterized by violaceus flat topped papules in variable size. It may involve body surface areas such as mocus membranes. Some studies have reported an association between oral LP ad diabetes mellitus. The aim of this study was to compare the frequency of diabetes mellitus between patients with and individuals without LP.
Methods: A case-control study was done on 30 patients suffering oral LP as case group and 60 healthy individuals as control group. Diagnosis of oral LP was confirmed by typical clinical and histopathologic findings. Participants in control group were selected from general population after matching for sex and age. Venipuncture was done to take 5 ml blood sample for measuring fasting serum blood glucose levels in both groups. A repeated blood sampling was done for ones with abnormal results in the first sampling. Findings of the study were analyzed using SPSS 16.0 statistical software.
Results: Thirty LP patients [man 13 (43.3%), woman 17 (56.7%)] with mean age (mean±stabdard deviation) of 46±13.7 years and 60 healthy individuals [man 26(43.3%), woman 34 (56.7%)] with mean ages of 46±14 years were recruited to this study. In case group only one person (3.3%) suffered from diabetes mellitus, but none of healthy group had fasting blood sugar above the normal value. In quantative evaluation, mean level of fasting blood sufar was 102.5±33 mg/dL in case group and 111.1±49.3 mg/dLin control group (P=0.09).
Rezvan Talaee, Abbas Doroudgar, Seyyed Gholamabbas Muosavi, Nasrin Abdevali,
Volume 2, Issue 3 (9-2011)
Abstract
Background and Aim: Diabetic neuropathy occurs in about 50% of individuals with long-standing type 1 and type 2 diabetes mellitus. The aim of the study was to detect sensory neuropathy in diabetic patients at risk for foot ulceration, using monofilament and neuropathic symptoms in Diabetes clinic of Kashan University of Medical Sciences from 2008 to 2010.
Methods: Three-hundred and fifty-two diabetic patients were enrolled in this cross-sectional study. Firstly patients were surveyed with a questionnaire concerning their subjective symptoms. The neuropathic symptoms were assessed using a quantitative neuropathy symptom score. Then the patients were examined by 5.07/10g monofilament. Data description and analysis were performed by reporting mean ± standard deviations, proportions, odds ratios (OR) and 95% confidence interval (95% CI) and conducting chi square and kappa tests.
Results: 15.6% of patients had sensory neuropathy using monofilament test. 19.4% of men and 14.3% of women had neuropathy (OR=1.4, P=0.24). The mean duration of diabetes in patients with neuropathy was longer than patients without neuropathy (9.96 vs 9.68 year, P>0.05). 72.7% of patients with history of foot ulcer had neuropathy (OR=16.6, P<0.001). According to neuropathic symptoms 17.6% of patients had no neuropathy, 12.8% had mild neuropathy, 41.8% had moderate neuropathy and 27.8% had severe neuropathy.
Conclusion: Screening with monofilament test is necessary for all diabetic patients to prevent diabetic foot ulcer development, without considering neuropathic symptom
Nafiseh Esmaeili, Tahereh Soori, Nooshin Shirzad, Maryam Vahid-Moghadam, Abbas Karimi,
Volume 6, Issue 3 (10-2015)
Abstract
Background and Aim: Pemphigus vulgaris is the most common autoimmune blistering disease. Prednisone, commonly in combination with an immunosuppressive adjuvant such as azathioprine or cyclophosphamide, is the standard treatment for pemphigus vulgaris. Approximately 5% to 15% of mortality of the disease is due to the complications of corticosteroids therapy. The aim of this study was to determine the prevalence and risk factors of steroid-induced diabetes in pemphigus patients hospitalized in Razi hospital, Tehran in 2009 and 2010.
Methods: In this cross-sectional study, 177 first-time admitted pemphigus vulgaris patients were studied regarding presence of risk factors for steroid-induced diabetes. Those risk factors were included age, sex, blood pressure, body mass index (BMI), family history of diabetes, medications used before and after initiation of treatment, fasting blood sugar (FBS) , triglyceride (TG) high density lipoprotein (HDL), low density lipoprotein (LDL) levels at the time of admission, and three weeks after the treatment was started.
Results: Twenty-nine patients (16.3%) were diagnosed with diabetes based on three weeks FBS levels evaluations. There were significant associations between BMI, HbA1c and taking nervous system agents and diabetes (P<0.05), but the differences between sex, family history, blood pressure, TG, LDL levels and occurrence of diabetes were not significant (P>0.05).
Conclusion: Close monitoring of FBS levels before and within the first three weeks of the initiation of steroid therapy allows early detection of storied-induced diabetes in pemphigus patients. Moreover, evaluation of other risk factors associated with diabetes may provide the opportunity of early diagnosis and treatment of steroid-induced diabetes.
Zaynab Variji,
Volume 9, Issue 1 (4-2018)
Abstract
Introduction: Foot ulcers which can result in physical and psychological casualties are commonly observed in diabetes mellitus. On time diagnosis and appropriate management can prevent undesirable events. We report a patient with diabetic ulcer and myiasis.
Case Report: A 70 year old man came to our wound clinic with bilateral plantar ulcers. Many larvae were seen in gangrenous tissue of the ulcer.
Conclusion: Prompt care and considering all factors effective in wound progression leads to prevention of disabilities in diabetic patients.
Mahdi Gheisari, Khalil Forouzannia, Paria Peydayesh, Khatereh Zahedi,
Volume 10, Issue 3 (11-2019)
Abstract
Background and Aim: According to the limited clinical observations and researches on cutaneous complications and hair growth changes of donor's site extremities, this study aimed to compare hair growth changes and cutaneous complications of donor's site extremity in patients who underwent coronary artery bypass graft between diabetic and non-diabetic patients.
Methods: Patients who attended the heart surgical clinic for routine follow-up 3-6 months after CABG (coronary artery bypass grafting) were evaluated. Their donor's sites in both extremities were compared with each other. Cutaneous changes were assessed and recorded by a dermatologist. After recording data, the incidence of these complications and the differences between diabetic and non-diabetic patients were evaluated.
Results: From the 97 participants of this study, 77 were male and 20 were female. Of these patients 29 were diabetic. Ten had hypertrichosis, 3 had hair loss in donor's site extremity, 16 had hyperpigmentation changes, 21 had itches, 26 had colloid scar changes, 3 had dermatitis, and 9 had wound site infection. In this study there was no statistically significant difference regarding the incidence of complications in diabetic patients compared to non-diabetic patients (P>0.05).
Conclusion: The cutaneous complications in this study were similar to previous studies and the only significant finding was the incidence of hypertrichosis in donor's site extremity. In order to determine the prevalence and persistence of the complications more accurately, further studies on larger populations including follow-up of complications are warranted.
Hamidreza Ahmadi Ashtiani, Alireza Firooz, Hossein Rastegar, Amirhosein Askaripour,
Volume 10, Issue 4 (1-2020)
Abstract
A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.
Ali Yousefi, Athar Moin, Ali Davati,
Volume 12, Issue 3 (11-2021)
Abstract
Background and Aim: Androgenetic alopecia is a type of androgen and genetic dependent hair loss and although it is more of a beauty issue, but in recent years studies have shown that this type of alopecia is associated with underlying disorders such as coronary artery disease. The aim of this study was to evaluate the frequency of androgenetic alopecia in hospitalized patients and its relationship with the history of coronary heart disease and its risk factors.
Methods: In this cross-sectional descriptive-analytic study, 250 patients (125 women and 125 men) admitted to Shahid Mostafa Khomeini Hospital in Tehran from October to December 2020 were examined and after examination and data collection, the data were analyzed using SPSS statistical software SPSS Statistics 25 version.
Results: The prevalence of alopecia was generally 46.8% in hospitalized patients, 61.6% in men and 32% in women. The prevalence of coronary heart disease in hospitalized patients was 25.6%, 34.4% in men and 16.8% in women. In patients with alopecia, the frequency of history of coronary heart disease was 39.31%, the history of hypertension was 20.8%, history of hyperlipidemia was 17.2%, history of diabetes was 14.4% and the smoking history was 15.6%. All of these factors were significantly associated with alopecia, except for smoking.
Conclusion: According to the results of this study, the frequency of androgenetic alopecia in patients admitted to the hospital is common and its prevalence in men is more than twice that of women. History of coronary heart disease and its risk factors in patients with alopecia are high, and have a significant relationship with it. This can be important and help in screening and early diagnosis of coronary heart disease and its subsequent prevention.
Negar Asghari Hosori, Zeinab Bagheri,
Volume 15, Issue 2 (8-2024)
Abstract
The limitations of common needles in drug delivery, such as pain, infection, and side effects, have become a stimulus to search for more efficient alternatives. Meanwhile, microneedles have brought new hope in skin drug delivery. These microstructures are temporarily placed in the upper layers of the skin and provide a painless and non-invasive way for drugs to pass through the skin barrier. Diversity in the design and ingredients of microneedles allows the release of a wide range of drugs with high efficiency and low side effects. On the other hand, nanomedicines are proposed as an ideal alternative due to the limitations of traditional drugs and the need for more targeted and less detrimental options. Nanomedicines are new drug delivery systems that are designed and produced in nanometer dimensions. These small particles can carry and release drugs directly to the target cells with high precision and efficiency. By reducing side effects and increasing the effectiveness of treatment, nanomedicines can play a key role in improving the quality of treatment for various diseases. Considering the unique advantages of the combination of microneedles and nanomedicines, it is an important issue to investigate different strategies for using these new systems in drug release. In this article, this issue has been investigated as well as the applications of nanomedicine transfer by microneedle in the treatment of diseases and the upcoming challenges of this emerging technology.
