Showing 4 results for Filler
Mona Malekmohammadi, Hossein Abdol Tehrani, Nasser Aghdami,
Volume 2, Issue 3 (9-2011)
Abstract
Hyaluronic acid (HA), the main and most important constituent of extracellular matrix, is a glycosaminologycan with water-absorbing capacity found in large amount in growing and repairing tissues. One of the main causes of skin problems, particulary in aging skin, is HA deficiency. More than half of the body HA is in the skin and is necessary for the maintenance of internal matrix and several cellular functions. Filler gels containing HA are used to repair skin defects. As these substances are derived from animals and bacteria, not the human, may cause skin reactions and have short half-life. So efforts to maintain and/or increase HA secretion from skin fibroblasts are important in the prevention and treatment of skin aging.
Aniseh Samadi, Mansour Nassiri Kashani, Azin Ayatollahi, Zahrabeigom Moosavi, Hasti Ahmdian Yazdi, Alireza Firooz,
Volume 14, Issue 4 (2-2024)
Abstract
Background and Aim: Recently, many Iranian companies have started manufacturing hyaluronic acid based dermal fillers. Current review aimed to assess and compare the clinical safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers.
Methods: The first part of the study reported, the overall safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers for improvement of nasolabial folds in 150 participants (age 44.30±9.97 years) using clinical and objectives assessment methods. In the second part, we performed a comparative study among 5 tested dermal fillers.
Results: Generally, at weeks 2, 12, and 24, 80.6%, 63.3%, and 60.66% of the participants, showed one grade or more improvement in the severity of nasolabial folds respectively. In all visits, the nasolabial folds biophysical parameters as well as the echo density dermis improved significantly compared to baseline. In comparative study, two fillers with the hyaluronic acid concentration of 24 mg/ml, showed the best objective efficacy, while in clinical evaluations, the filler containing mannitol has the best performance in reducing the severity of nasolabial folds showed.
Conclusion: Iranian hyaluronic acid based dermal fillers showed different levels of safety and efficacy for improvement of moderate to severe nasolabial folds, with efficacy.
Nahid Hassanzadeh Nemati, Kimia Rezaie Moghadam,
Volume 15, Issue 1 (5-2024)
Abstract
Cosmetic dermatology has seen significant advancements in developing new materials and techniques to enhance skin beauty and combat signs of aging. One notable development is creating and analyzing fillers made by combining hyaluronic acid and polycaprolactone. This innovative filler type has gained popularity due to its unique properties, exceptional skin rejuvenation capabilities, and effectiveness in facial contouring. This study gathered information on dermal fillers and the effects of using hyaluronic acid and polycaprolactone by referencing papers from various databases such as Civilica, PubMed, Google Scholar, Science Direct, and SID. The authors conducted a study to explore the benefits and drawbacks of utilizing hyaluronic acid and polycaprolactone and their impact on filler durability and injectability. Research conducted by experts and studies on cosmetic fillers has highlighted the positive effects of hyaluronic acid and polycaprolactone, two powerful substances widely discussed in the beauty industry. Further research could improve the understanding and utilization of hyaluronic acid/polycaprolactone fillers, enhancing skin cosmetic treatments and increasing patient satisfaction.
Maryam Nasimi, Toomaj Shahverdi, Fatemeh Momeni, Vahid Tajari, Faezeh Khorasanizadeh, Martin Kassir,
Volume 16, Issue 4 (2-2026)
Abstract
Background: Dermal filler injections have gained increasing popularity for face augmentation, skin wrinkle treatment, and contouring. Although generally safe, complications may develop following filler administration. Granulomatous formation reactions to dermal fillers are important adverse reactions. Dental procedures are highly recognized to be a trigger for delayed granulomatous reactions at dermal filler field.
Case presentation:
Case 1: A 32-year-old woman presented with erythema, tenderness, and edema 6 months after ultra4 Juvéderm filler injection at left and right nasolabial folds and both lips. One month prior to the appearance of these symptoms, she had undergone dental scaling and polishing. Histopathological results showed granulomatous reaction to dermal filler. The patient was successfully treated with 2 doses of intralesional corticosteroid injection.
Case 2: A 58-year-old woman presented with nodular growths on her left marionette line and right nasolabial fold subsequent to dental scaling and polishing. Two years prior, she had received injections of Ellansé and Lunaphil Volume dermal filler at both nasolabial folds. An ultrasound examination confirmed a granulomatous response to dermal fillers. The symptoms significantly improved after 2 doses of intralesional corticosteroid injection.
Case 3: A 48-year-old woman, developed a tender erythematous induration in the nasolabial folds where she had received Ellansé filler injection 4 years earlier. The symptoms appeared one month after a surgery on buccal area. Ultrasonography revealed granuloma formation. A regimen of systemic and intralesional corticosteroids resulted in a significant improvement of the symptoms.
Conclusion: These cases highlight dental procedures as a clinically shown factor for granulomatous responses following dermal filler injections, including dental and surgical interventions. More research is required to enhance understanding of the mechanisms and risk factors involved.
