Showing 4 results for Formulation
Sara Bahrainian, Atefeh Naeimifar, Saman Ahmad Nasrollahi,
Volume 11, Issue 4 (1-2021)
Abstract
Full term newborns have a skin that rapidly develops towards adult skin. From the anatomical point of view, the differences are limited, but some changes at birth are responsible for the physiological differences between the skin of infants and adults. Newborns skin exhibits the same barrier function and absorption properties as adults, but external conditions for newborns may be different from those for adults, and these differences may lead to different skin absorption profiles between these two groups. Also, a baby's temperature regulation (transepidermal water loss (TEWL) and sweating) is not completely developed and the skin becomes easily infected, which is mainly due to changes in pH and immaturity of the skins defense system. This implies why only cosmetics with safe ingredients should be used for newborns. The initial aim is to formulate a simple, pure, gentle and pathogen-free product. Systemic side effects are not expected with washable products but should be taken into account for leave-on products. Great attention should be given to cosmetic products used in the napkin area, especially where there is a possibility of rash. If necessary, more safety precautions should be taken for these products.
Atefeh Naeimifar, Saman Ahmad Nasrollahi,
Volume 12, Issue 2 (8-2021)
Abstract
Microneedles consist of micron-sized projections similar to needles. They are capable of piercing through the stratum corneum and increase the permeation of active ingredients. Besides active pharmaceutical ingredients, microneedles can also deliver cosmetic agents, biotherapeutics like insulin and vaccines and also are used in diagnostic purposes. This article examines the types of microneedles. It also describes the function, classification, and differences between them.
Kiana Shomali, Atefeh Naeimifar, Saman Ahmadnasrollahi,
Volume 12, Issue 4 (2-2022)
Abstract
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%),
urea-containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea-based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti-inflammatory and anti-fungal drugs, due to its activity as a penetration enhancer.
Samira Shahhosseini, Moazameh Kordjazi, Saman Ahmadnasrollahi, Seyedmahdi Ojagh, Atefe Naeimifar, Salim Sharifian,
Volume 15, Issue 1 (5-2024)
Abstract
Background and Aim: Marine seaweeds are a valuable source of bioactive ingeredients with the possibility of different effects in cosmeceutical industries such as skin health products. One of the main characteristics of the skin is moisture which plays an important role in maintaining metabolism, enzymatic activity, mechanical properties, appearance and protective barrier. The objective of the present study was to formulate the water extract of brown algae Sargassum tenerrimum with antioxidant and antibacterial properties as a moisturizing cream to evaluate physicochemical stability and microbial growth.
Methods: Algae were collected from the Persian Gulf intertidal zone and was washed with seawater, then transferd to Seafood Processing Laboratory in Gorgan University of Agricultural Sciences and Natural Resources for extraction process, after that formulation of 1% moisturizing cream was made at Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical Scinces. Statistical analysis of antibacterial properties of water extract was performed by SPSS software version 22 and one way ANONA was used to analyse the data. The comparison between the means were investigated by Duncan’s test used for measuring significant differences at 5 percent level. Finally, the charts were created by using Excel software. The results of the study were reported as mean ± standard deviation.
Results: According to the results, the prepared 1% cream was completely stable and homogeneous in room temperature and oven for 6 months and successfully passed microbial tests.
Conclusion: In view of the above mentioned, the manufactured cream efficacy was well done and can be introduce as a skin moisturizing agent.
