Mohammadali Nilforoushzadeh, Seyyed Hossein Hejazi, Hajar Zarkoob, Leila Shirani Bidabadi, Gholam Reza Asghari, Seyyed Mohsen Hosseini, Elaheh Haftbaradaran, Fariba Jaffary,
Volume 1, Issue 2 (6-2010)
Abstract
Background and Aim: There are some reports regading the anti-inflammatory and antimicrobial effect of honey and Nigella sativa and their therapeutic effects in improvement of wound healing. This study was designed to evaluate the efficacy of adding honey and Nigella sativa extract compared to honey alone in patients with cutaneous leishmaniasis receiving intralesional Glucantime.
Methods: In this clinical trial, 150 patients with confirmed cutaneous leishmaniasis were randomly allocated into two groups. One group was treated with topical honey twice daily along with weekly intralesional injection of Glucantime. In the second group, patients were treated with topical honey and 60 % hydroalchoholic Nigella sativa extract instead of honey alone. The patients were treated until complete healing of the ulcer or for maximum of 12 weeks.
Results: At 12 weeks, complete cure was achieved in 61 (81.3%) of patients treated with topical honey and 60 % hydroalchoholic Nigella sativa extract versus 48 (64%) in the second group (P=0.002).
Conclusion: The efficacy of adjunct honey and Nigella sativa extract along with intralesional Glucantime is more than honey alone in increasing complete cure rate and decreasing the residual scar size and the required dose of Glucantime.
Hana Mirzabeigi, Mina Mamizadeh, Ali Delpisheh, Mohammad Mehdi Safari, Morteza Mansourian,
Volume 4, Issue 4 (12-2013)
Abstract
Background and Aim: Eczema is a common chronic inflammatory skin disease that reduces quality of life of the patient. The present clinical trial with control group aimed to determine therapeutic effects of natural honey plus cold cream compared to cold cream alone on hand eczema.
Methods: Through a blind clinical trial, 72 patients with hand eczema were categorized in two equal groups. The first group used a mixture of honey plus cold cream and the other group applied cold cream alone. Patients used either Treatment 2 times a day for 21 days on their lesions. The effects including relief of symptoms such as dryness, redness, itching and scaling were evaluated by a dermatologist as well as the patients themselves. The results were analyzed using SPSS software and P values less than 0.05 were considered statistically significant.
Results: According to the physician’s evaluation, 26 (36.1 %) patients in group combined honey and coldcream, were cured and 9 (59.12%) patients do not recover while in cold cream alone group, 6 (3.8%) patients were recovered and 30 (7.41%) patients did not. This difference was statistically significant (P<0.001). According to the patients evaluation in group combined honey and coldcream, 26 (36.1%) felt better and 9 cases (59.12%) did not, while the corresponding rates in group cold cream alone were 6 (2.8%) and 30 patients (7.1%) respectively. This finding was statistically significant (P<0.001).
Conclusions: With respect to the therapeutic effects of honey on hand eczema, it is recommended to use honey with other therapies to treat eczema.
