Search published articles


Showing 3 results for Isotretinoin
Clinical and laboratory adverse effects of oral isotretinoin in patients with nodulo-cystic acne
Pouran Layegh, Hesamolddin Saeedian, Mahnaz Banihashemei, Habibollah Esmaeilee, Akram Momenzadeh,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: Oral isotretinoin is the only drug that is effective on almost all factors involved in the pathogenesis of acne. Although several studies have been conducted on side effects of this drug, few studies have been conducted on Iranian patients. The aim of this study was to evaluate common clinical and laboratory side effects of this drug in patients with nodulo-cystic acne in Mashhad, Iran.
Methods: One-hundred nodulo-cystic acne patients without previous history of hematologic, renal or hepatic diseases and with negative pregnancy tests (in female patients) were enrolled to this study. Patients were treated with standard regimen of oral isotretinoin with a cumulative dose of 120 mg/kg for a treatment course. Demographic data of each patient and results of baseline laboratory tests including serum lipids profile, liver function tests and cell blood counts were recorded.Laboratory tests and the clinical side effects were assessed every two months.
Results: All patients completed treatment course. The most common side effects were cheilitis (87%), dry skin (71%), various types of dermatitis (37%), epistaxis (21%), arthralgias and myalgias (21%). All side effects were mild and treatment discontinuation was not necessary in any case. Although some changes were observed in serum lipid profiles and liver function tests, but these changes were within normal range.
Conclusion: Treatment with oral isotretinoinis associated with few complications in patients with nodulo-cystic acne, but the possibility of serious side effects should always be considered.

Relationship between systemic isotretinoin and induction of depression in acne vulgaris patients
Farhad Handjani, Md, Maryam Sadat Sadati, Md, Ali Firoozabadi, Md, Vala Rezaei, Sara Akramzadeh,
Volume 4, Issue 2 (6-2013)
Abstract
Background and Aim: Acne is one of the most common skin diseases. One of the best treatments is systemic isotretinoin. Some studies link its use with depression, psychiatric problems and suicide, but it is still a matter of debate. So, this study was designed to determine the frequency of depression in acne patients, treated with isotretinoin.
Methods: Fifty-nine acne patients between 16 -30 years old were included. The patients received 0.5-1 mg/kg/day isotretinoin for 16 weeks. At the beginning and at the end of study, the Beck questionnaire was completed by the patients and the results were analyzed.
Results: The mean score of the Beck questionnaire was 13.19 at the beginning of the study and 14.80 after 4 months of treatment with isotretinoin (P=0.0001).
Conclusion: The results of this study showed that isotretinoin may have a small, but still noticeable increase in depression scores of acne patients. However, it is important to consider that various other parameters, such as individual’s psychological status at the time of completing the questionnaire, might influence the results. So, further studies with more patients and longer durations, and the use of other pertinent questionnaires, are recommended.
Comparison of the efficacy of isotretinoin 0.05% niosomal gel versus adapalen 0.1% gel in the treatment of acne vulgaris: A randomized, double-blind clinical trial
Saman Mohammadi, Payam Khazaeli, Simin Shamsi Meymandi, Mahin Aflatoonian, Maryam Khalili Meybodi, Niloofar Mehrolhasani, Azadeh Mohebi, Yuns Jahani,
Volume 7, Issue 2 (7-2016)
Abstract

Background and Aim: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Retinoids are used as the first line therapy in acne. Systemic absorption and skin irritation including redness, pruritus and exfoliation are some of their side effects. In this study we compared the efficacy of isotretinoin 0.05% niosomal gel versus adapalen 0.1% gel in treatment of acne vulgaris.

Methods: In this randomized double blind clinical trial, 144 patients with mild to moderate acne vulgaris aged from 15 to 30 years were enrolled. The patients were randomly allocated into two groups of A, whom were treated with isotretinoin 0.05% niosomal gel and B whom were treated with adapalen 0.1% gel. The patients were evaluated for clinical reponse, decrease in the number of inflammatory and non-inflammatory lesions and side effects after 2, 4, 8, and 12 weeks of the initiation of treatment.

Results: At the end of the study the clinical responses of comedones and inflammatory lesions in isotretinoin 0.05% niosomal gel group were 68% and 79%, in comparison with 65% and 76% in the adapalen gel group,  respectively. The differences were not statistically significant. At the end of the treatment period more decrease in number of inflammatory and non-inflammatory lesions were seen in group A patients (niosomal isotretinoin) than group B (adapalen 0.1% gel) (P<0.001). Also side effect of skin redness was found more in group B (P<0.001).

Conclusion: Isotretinoin 0.05% niosomal gel has less side effects and more efficacy in the treatment of mild to moderate acne vulgaris in comparison with adapalen 0.1% gel.


Page 1 from 1     

© 2025 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by : Yektaweb