Elham Ziaeifar, Azadeh Goodarzi, Nasrin Saki,
Volume 10, Issue 1 (4-2019)
Abstract
Probiotics are living microorganisms that, when used adequately, have beneficial effects on the host, and their superiority is that they are safe and secure for the host. The use of probiotics in addition to the digestive tract, has been studied in immune function, skin diseases, diabetes, cancer, liver disease, hypertension, urogenital system and oral cavity. In general, probiotics seem to be a promising and safe treatment. Nevertheless, more extensive studies are needed to use probiotics as alternative treatments along with old treatments. In dermatology, there is also a widespread use of probiotics and prebiotics. The use of probiotics has been studied in the treatment of atopic dermatitis, acne, eczema, allergic diseases, skin aging, bacterial and fungal infections, chronic wound healing, including diabetic foot ulcers, with promising results. In this review, papers related to the use of probiotics in the treatment of skin diseases were searched in data bases of Pubmed, Google scholar and Medline. Relevant papers were selected and presented. It is expected that probiotics will be used as complimentary treatment in several skin disorders.
Fatemeh Yazdani Hamid,
Volume 14, Issue 1 (5-2023)
Abstract
Treatment of chronic conditions like diabetic foot ulcer (DFU) is challenging due to increased susceptibility for infection and delayed wound healing. Complexity of existing therapy, adverse effects and microbial resistance emphasizes the need of an alternative approach for the management of DFU. The increasing body of evidence associated with probiotic application in diverse disease states merits its use in wound healing and infection too. Different probiotic strains have shown their efficacy in various infections like gut infections, oral infections and urogenital infections. Experimental studies have demonstrated probiotics’ ability for gastric ulcer healing. Underlying mechanism of the above therapeutic effects of probiotics involves modulation of local and systemic immunity. The hypothesis is based on the concept that mechanism of anti-infective and ulcer healing action of probiotics will be similar in peripheral wounds and ulcers as on any other part of the body. This paper focuses on the hypothesis that topical formulation of probiotics may be effective for the treatment of diabetic foot ulcers.
