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Showing 6 results for Pruritus
Groin pruritus in female patients referred to dermatology and gynecology clinics of Yahya-Nejad Hospital in Babol
Soodabeh Tirgar-Tabari, Shahnaz Barat,
Volume 1, Issue 4 (12-2010)
Abstract

Background and Aim: Pruritus is usually caused by a primary skin disorder or a systemic disease. Causes of groin pruritus are fungi, eczema, bacterial diseases, neurodermatitis, scabies and many other skin disorders. This study was performed to find the common causes of groin pruritus in female patients that referred to dermatology and gynecology clinics of Yahya-Nejad hospital in Babol.
Methods: This descriptive study was performed on patients with groin pruritus from the begining of winter 2006 until the end of autumn 2007. Other information including name, age, height, weight, previous drug consumption, simultaneous infection in partner or other members of the family, duration of infection, underlying disease and result of examination were recorded in a questionnaire for each patient.
Results: 115 patients were studied. The average age of patients was 41.2 years (15-75 years old). The highest disease frequency was seen in 48 cases (41.7%) in summer. Most cases (33 patients [28.7%]) were between 46-55 years of age. Most of patients (28.7%) had a BMI from 25 to 29.9 (over weigh). The most common causes of groin pruritus in all seasons, ages and BMIs were tinea cruris in 55 cases (47.8%) and seborrheic dermatitis in 29 cases (25.1%).
Conclusion: Considering common causes of groin pruritus, season and patient's weight can be helpful in diagnosis and early treatment of groin pruritus.


TGF-β1 gene expression in skin lesions and correlation with pruritus in mustard gas exposed victims
Isa Khaheshi, Saeeid Keshavarz, Majid Shohrati, Abbasali Fooladi Imani, Mohammadreza Nourani,
Volume 1, Issue 4 (12-2010)
Abstract

Background and Aim: As a blistering agent, mustard gas causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like pruritus. TGF-β1 molecule is a cytokine with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-β1 gene exprtession in victims exposed to mustard gas and the correlation with the severity of their pruritus.
Methods: 17 victims exposed to mustard gas, 17 patients with chronic contact dermatitis and 10 healthy individuals were included in the study. The assessment of TGF-β1 expression in their skin samples was conducted by semi-quantitative RT-PCR followed by immunohistochemistry and classification of patients was done by pruritus severity scoring system (0-3).
Results: There was a significant decrease in TGF-β1 gene expression in mustard gas exposed victims comparing to chronic contact dermatitis group and the control group (P<0.05). In addition, in the absence of TGF-β1 expression, the severity of pruritus in the patient group significantly increased (P<0.05).
Conclusion: TGF-β1 has a significant role in chronic inflammatory skin lesions caused by mustard gas.


Frequency of the uremic pruritis and its associated factors in hemodialysis patients in the Golestan Province dialysis centers in 2009
Ali Abbasi, Alireza Shariati, Hamid Asayesh, Mohammad Mahdi Ebrahimi,
Volume 2, Issue 3 (9-2011)
Abstract

Background and Aim: Pruritus is one of the most disabling complications in patients with chronic renal failure that have negative effect on patients' quality of life. The aim of this study was to determine the frequency of the uremic pruritus and its associated factors in hemodialysis patients referred to the dialysis centers in Golestan Province.

Methods: In this cross-sectional study, all 375 patients referred to eight dialysis centers in Golestan Province were selected via census sampling method. Data were gathered by using demogeraphic and Yosipovitch pruritus questionnaires. Data analysis was performed using SPSS software through conducting t and chi square tests.

Results: The mean ± standard deviation of patients' age was 48.36 ± 13.27 years and 51.2% of patients were male. One hundred and eighty one (48.3%) patients had uremic pruritus. The lowest and highest frequency of pruritus among surveyed centers were 37.9% and 57.1%, respectively. 60.2 % of patients had localized pruritus and the most common location was back (68.8 %). There was a statistically significant correlation between uremic pruritus with number of dialysis session (P<0.001) and serum level of phosphorus (P<0.001). 

Conclusion: The results indicated that uremic pruritus is still one of the most common problems in hemodialysis patients. Therefore it seems necessary providing ways to eliminating or reducing the problem.


Structural reliability and validity of Persian translation of
Niloofar Tari, Hamidreza Mahmoodi, Seyyed Hamed Hosseini, Kamran Balighi, Maryam Daneshpazhooh, , , ,
Volume 3, Issue 2 (6-2012)
Abstract

Background and Aim: Pruritus is a major symptom of dermatologic diseases and a common symptom of systemic diseases. Severity of itch cannot be measured objectively. It’s usually determined to using a Visual Analogue Scale (VAS). But none of them can determine the effect of pruritus on patients' quality of life. So in the present study we sought to translate and develop a validated reliable Farsi version of pruritus specific quality of life instrument, ItchyQoL.

Methods: ItchyQoL questionnaire was translated to Farsi by two bilingual people, and then it was back-translated to English by two other bilinguals. These two questionnaires were matched and revised and the final Farsi questionnaire was established. Forty four patients with dermatologic pruritus filled the questionnaire at the baseline and 72 hours later, and the structural reliability and validity of it was analyzed.

Results: The questionnaire had internal consistency and reproducibility. The questionnaire reliability was also analyzed by test-retest which was significant. Construct validity was analyzed by examining the relationship between intensity and frequency of itching with the total score in the three main axis symptoms, which was significant in all except the dysfunction axis.

Conclusion: The Farsi version of ItchyQoL questionnaire has favorable reliability and validity.


Frequency of primary generalized pruritus in bullous pemphigoid patients referring to Tehran Razi Hospital between 1996 to 2011
Nafiseh Esmaeili, Sedigheh Talebi, Kambiz Kamyab, Abbas Karimi,
Volume 5, Issue 4 (1-2015)
Abstract

Background and Aim: Bullous pemphigoid (BP) is an acquired autoimmune disease with subepidermal blisters commonly seen in the elderly over 60 years. Although the disease is usually manifested with tense blisters, but in some cases generalized pruritus is the only symptom of disease, which is less studied.

Methods: In a retrospective study, the medical records of 416 BP patients confirmed in pathology laboratory were evaluated for clinical findings, direct immunofluorescence (DIF) testing for BMZ-binding IgG antibodies and histological findings.

Results: Of the 416 confirmed BP patients, 213 were male and 203 were female. The mean age of patients was 64.36 years. Thirty four patients at the onset of the disease had generalized pruritus, which in the course of the disease, 29 patients also showed other symptoms of the disease. In 5 patients generalized pruritus was seen as the only symptom. Concerning to the results of DIF, 117 (90%) patients showed autoantibody deposit, and in 13 (10%) patients the test was negative. There was no significant relationship between DIF results and histological findings (p> 0.05).

Conclusion: According to the findings of this study, generalized pruritus is uncommon as the first symptom of the disease. There was not any association between generalized pruritus and histological observations including dermal edema, presence of eosinophils in tissue, subepidermal blister as well as DIF results. Further studies on the early detection of the disease are required to decrease complications of the disease.
 
Assessment of quality of life in hemodialysis patients with uremic pruritus from Iranian Medicine view
Seyedmajid Ghazanfari, Jamshid Jamali, Azadeh Saki, Mohammadreza Noras, Roshanak Salari, Ali Khorsand Vakilzade, Farzane Sharifipour,
Volume 10, Issue 3 (11-2019)
Abstract

Background and Aim: Pruritus is one of the most common problems of chronic kidney diseases. Different treatment modalities, while extending the life span of patients, can lead to changes in their lifestyle, health status and ultimately change their quality of life (QOL). Understanding the different aspects of patients' QOL leads to better services provided by health care teams to improve the patients' QOL. The aim of this study was to evaluate the quality of life of hemodialysis patients with uremic pruritus in Mashhad in 1396 with a view to Iranian Medicine.

Methods: This descriptive-analytical study was performed on 52 patients. Data collection was done by the World Health Organization QOL and researcher-made demographic Questionnaire and SPSS 16 software was used for data analysis.

Results: The mean age of patients was 51.73 years and mean duration of dialysis was 41.42 months. Total score of life quality was 56. The lowest and highest scores were seen in physical and environmental dimensions. There was an inverse significant relationship between some aspects of QOL with hemoglobin and creatinine and a direct significant relationship with age, diabetes, hypertension and hyperlipidemia (P<0.005).

Conclusion: Hemodialysis patients' QOL is lower than others and several factors can improve it. Special attention to the individual characteristics of hemodialysis patients can be helpful in predicting their basic needs.


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