Showing 30 results for Rat
Amir Houshang Ehsani, Mostafa Mirshams Shahshahani, Zahra Hallaji, Pedram Noormohammadpour,
Volume 1, Issue 1 (3-2010)
Abstract
Background and aim: Actinic keratoses (AKs) are the third commonest complaint of patients visiting dermatologists. Topical treatment including 5-fluorouracil (5-FU) are among the commonest available therapies. According to local irritation induced by topical 5-FU The aim of current study was to compare efficacy of two different 5-FU based regimens with different application routes.
Methods: Patients with AKs confirmed by skin biopsy, matching our exlusion criteria were enrolled. Subjects randomized in two groups, receiving topical 5% 5-FU once daily or alternatedaily respectively. Two weeks after the end of one month period of the study, rate of reduction in number of lesions was documented by blinded academic dermatologists as well as treatment side effects.
Results: a total of 38 patients (23 male and 15 female) completed the study. Rate of side effects were lower in alternate-day applying patients (P<0.05) while rate of response to therapy were comparable in both groups (P>0.05).
Conclusion: alternate-day route for application of topical 5-FU is an acceptable alternative for classic daily application, to reduce rate of side effects and enhancing patients compliance.
Afshar Ramezanpour, Abdolamir Feizi, Ramin Mohammadi,
Volume 2, Issue 1 (3-2011)
Abstract
Fabry disease is a X-linked lysosomal storage disorder due to alpha galactosidase A deficiency leading to abnormal accumulation of glycosphingolipids in different parts of body. This case report introduces a 35-year-old man with diffuse keratotic erythematous papules. Histopathological evaluation of the skin biopsy suggested the diagnosis of angiokeratoma. With attention to his nephropathy and the same skin lesions and renal involvement in his brother, which led him to receive renal transplantation, the diagnosis of Fabry disease was suggested.
Pouran Layegh, Hesamolddin Saeedian, Mahnaz Banihashemei, Habibollah Esmaeilee, Akram Momenzadeh,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: Oral isotretinoin is the only drug that is effective on almost all factors involved in the pathogenesis of acne. Although several studies have been conducted on side effects of this drug, few studies have been conducted on Iranian patients. The aim of this study was to evaluate common clinical and laboratory side effects of this drug in patients with nodulo-cystic acne in Mashhad, Iran.Methods: One-hundred nodulo-cystic acne patients without previous history of hematologic, renal or hepatic diseases and with negative pregnancy tests (in female patients) were enrolled to this study. Patients were treated with standard regimen of oral isotretinoin with a cumulative dose of 120 mg/kg for a treatment course. Demographic data of each patient and results of baseline laboratory tests including serum lipids profile, liver function tests and cell blood counts were recorded.Laboratory tests and the clinical side effects were assessed every two months.
Results: All patients completed treatment course. The most common side effects were cheilitis (87%), dry skin (71%), various types of dermatitis (37%), epistaxis (21%), arthralgias and myalgias (21%). All side effects were mild and treatment discontinuation was not necessary in any case. Although some changes were observed in serum lipid profiles and liver function tests, but these changes were within normal range.
Conclusion: Treatment with oral isotretinoinis associated with few complications in patients with nodulo-cystic acne, but the possibility of serious side effects should always be considered.
Alireza Khatami,
Volume 3, Issue 4 (12-2012)
Abstract
According to evidence-based medicine, randomized controlled clinical trials are a group of research designs which provides the highest level of clinical evidence, particularly regarding therapeutic or preventive interventions. Considering the dramatic increase in the number of published clinical trials in medical journals, the readership need to have knowledge about the problems that may occur during design and conduct of these studies, as well as about proper reporting of them. Due to importance of these studies in clinical medicine, several guidelines have been developed regarding designing, conducting and reporting clinical trials. One of the most important guidelines which has been developed to alleviate the problems in reporting randomized clinical trials is Consolidated Standards for Reporting Trials (CONSORT). In this article, some crucial points with regards to the report of the comparison of outcomes of interventions in randomized controlled trials will be reviewed briefly.
Adele Mobarak-Abadi , Razie Rajabi, Yusef Khani, Amir Almasi-Hashiani ,
Volume 4, Issue 3 (9-2013)
Abstract
Background and Aim: Skin cancer is the most common
malignancy in the world with high morbidity and relatively low mortality. Basal
cell carcinoma (BCC) is the most common type of cancer and its incidence is
increasing. The purpose of this study was to investigate the incidence of skin
cancer in the years 1386 to 1390 is in the Markazi Province, Iran.
Methods: In this study the data of Markazi Province Cancer Registry
were used and incidence rate was calculated per 100,000 person. Age
standardized incidence rates were calculated via direct standardization method
using world standard population. Finally, the data were analyzed using SPSS, Excel,
and WinPepi softwares.
Results: In Markazi Province, 958 patients with skin cancer
were recorded during 1386-90. The age-standardized incidence rates in these
years were 21.54, 12.06, 13.79, 18.29 and 15.79 per 100,000 people
respectively. There was no significant change in the trend of skin cancer incidence
rates.
Conclusion: Skin cancer was higher in men than women, and
most cases occur in the elderly. Development of screening programs is
recommended to detect skin cancer in its early stages in older men, especially
in those who have been exposed to the sun for long times.
Nafiseh Esmaeili, Mansoureh Akhavan, Hossein Mortazavi, Abbas Karimi,
Volume 4, Issue 3 (9-2013)
Abstract
Background and Aim: Bullous pemphigoid is an acquired
autoimmune disease with subepidermal blisters commonly seen in the elderly over
60 years old. The exact survival rate of the patients with bullous pemphigoid
was not available in Iran. The aim of this study was to evaluate the risk
factors of 5-year mortality of bullous pemphigoid patients.
Methods: In this retrospective study, 66 bullous pemphigoid
patients referred to Razi hospital from 1986 to 2006 were studied. Age, sex,
consumed corticosteroid type, duration of hospitalization, and clinical form of
bullous pemphigoid, ESR and comorbidities were evaluated to determine the risk
factors associated with patients’ 5-year mortality rate.
Results: Forty-seven patients (71.2 %) had
5-year survival. The most common comorbidities were cardiovascular diseases
(28.8%), diabetes (15%) and chronic respiratory diseases (9%). There was a significant
relationship between the age and the 5-year survival rate, in other words
patients aged over 70 years had a less 5-year survival rate (P<0.001). There was no statistically
significant association with gender, the type of corticosteroid, the disease clinical
forms, duration of hospitalization or ESR and 5-year survival (P>0.05).
Conclusion: The current study found a
significant relationship between the age of the patients and 5-year survival. Larger
studies considering more potential risk factors and more appropriate designs
might help to estimate the survival rate of patients with bullous pemphigoid
more precisely.
Saman Ahmad Nasrollahi, Hesam Alibakhshi, Alireza Firooz,
Volume 4, Issue 4 (12-2013)
Abstract
Background and Aim: Shampoos are surfactant systems to clean hair and body. Two kinds of surfactants are generally used in shampoo formulations: anionic and amphoteric. These agents, especially anionic ones may cause skin irritation and dryness after bathing. So, using a simple and fast method to determine the types and concentrations of surfactants can help to choose a product with high efficacy and low side effects. This study was aimed to determine surfactant concentrations using potentiometric titration method.
Methods: Ten hair and body shampoos were selected from Iran's market to determine concentration of anionic and amphoteric surfactants using potentiometric titration method with prepared standard solution.
Results: All formulations contain both surfactants, but one formulation did not have the amphoteric one.
Conclusion: When we want to choose a shampoo for irritated and dry skin, formulations with more amphoteric surfactant should be chosen because they are much milder on the skin in comparison with anionic surfactants. Potentiometric method which was described in this study is one of the easiest ways to find out which shampoo is suitable for each patient.
Maryam Mirzaei, Saeid Razi, Mahshid Ghoncheh, Abdollah Mohammadian Hafshejani, Hamid Salehiniya,
Volume 5, Issue 4 (1-2015)
Abstract
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Background and Aim: Skin
cancer is the most common cancer in the world, which is associated with
mortality, mortality and health care costs. Planning prevention and control
of this cancer, information about its incidence rates and incidence trends is
necessary. The present study aimed to determine the incidence rates and
trends of skin cancer in Tehran.
Methods: In this
cross-sectional study, necessary data were extracted from the Cancer
Registry, Ministry of Health and Medical Education between 2003 and 2008. Age
- and sex -standardized incidence rates were calculated and the incidence
rate trends were determined.
Results: Between 2003 and
2008, 7429 skin cancer cases were recorded, of which 4807 were men and 2622
were women. Skin cancer incidence had an increasing trend in Tehran and its
incidence rate has increased from 8.99 in women and 11.52 in men in 2003 to
18.03 in women and 28.16 in men in 2008, respectively. In addition, incidence
of skin cancer was increased with aging in both men and women. The incidence
rate was higher in men than women.
Conclusion: Skin cancer
incidence in Tehran is increasing, which could be due to population aging,
environmental risk factors, and changes in life style. More comprehensive
research is suggested to investigate the risk factors for this cancer in
Tehran.
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Mahnaz Banihashemi, Fakhrozzaman Pezeshkpoor, Sahar Aziziahari, Mohammad Tohidi,
Volume 5, Issue 4 (1-2015)
Abstract
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Anderson-Fabry
which is also known as Fabry disease is an X-linked recessive enzyme
deficiency disorder. Its clinical manifestations are caused by storage of
sphingolipids in the lysosomes of the endothelial, perithelial, and smooth
muscle cells, which is due to alpha galactosidase A enzyme deficiency. Its
hallmark dermatological manifestation is diffuse angiokeratomas known as
angiokeratoma corporis diffusum. Peripheral painful neuropathy, eye
involvement, cardiovascular problems, cerebrovascular complications, and
renal failure are other manifestations of Fabry disease.
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Herein,
we report a 22-year-old man who had been referred to a dermatology clinic for
evaluation of his skin lesions. The patient had diffuse angiokeratomas, which
were characteristic for Fabry disease as well as painful acral neuropathy.
Histpathologic examination of one of his skin lesions was reported as
angiokeratoma. Since cornea verticillata was observed in his eyes and he also
suffered from sensory-neural hearing loss, he was diagnosed as a case of Fabry
disease.
Freshteh Osmani, Ebrahim Hajizadeh, Parvin Mansoori,
Volume 6, Issue 1 (4-2015)
Abstract
Background and Aim: Psoriasis is an inflammatory skin disease, which is related to the immune system and is characterized by the rapid growth of skin cells. The aim of this study was to investigate some risk factors in psoriasis and also to check that whether the rate of recurrence is fixed or variable in different seasons by using a time-dependent coefficients rate model.
Methods: After reviewing the files of psoriasis patients that had been hospitalized in March 2011 to March 2014 in the dermatology ward of Imam Khomeini Hospital in Tehran, a total of 160 patients who had relapses leading to hospitalization, entered to the study. A rate model with time dependent coefficients by using R software version 3.1 was fitted and risk factors for recurrence were identified. Effect of the season on the recurrence of psoriasis was evaluated.
Results: Recurrence rate of psoriasis was 7.2 times higher in winters than in springs, which had the lowest recurrence rate. Spring and summer were associoated with lower recurrence rates. Effect of season on the relapse of the disease was significantly different for different seasons (P<0.01). Also, infection, stress, positive family history, hypocalemia, the normal number of white blood cells and temperature changes were associated with psoriasis relapse (P<0.05).
Conclusion: Recurrence rate of psoriasis is different in different seasons. Psoriasis recurrence rate was 7 times higher in winters in comparison with springs.
Nasrin Zand, Afshan Shirkavand,
Volume 6, Issue 4 (1-2016)
Abstract
Postsurgical scars are of significant concern to both the patients and surgeons. Different laser systems have been used to accelerate and improve the healing process in surgical scars. Some studies have demonstrated the benefits of prophylactic laser application on pre-scars. It seems that using laser energy in the early phase of the healing process may produce changes in the physiology of wound healing toward a more fetal-like tissue regeneration and healing. Laser-Assisted Skin Healing (LASH) is a new approach in which laser irradiation is applied immediately after surgery in order to improve the resulting surgical scars. LASH produces controlled homogenous heating throughout the full thickness of the skin around the wound which accelerates wound healing without thermal damage to the tissue.
The purpose of this paper is to provide an overview of the available peer-reviewed research literature on the application of LASH, the in-vitro, animal and human studies and the suggested mechanisms of action. Further studies are necessary to optimize the best laser parameters especially according to different skin phototypes and better understanding of the mechanisms of action.
Ali Asghar Rezanejad, Mohammad Reza Sobhan, Hamid Reza Gsemi Basir, Akram Ansar,
Volume 7, Issue 2 (7-2016)
Abstract
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease due to benign proliferation of dermal and subcutaneous capillaries. It is most commonly seen in young to middle-age females. Skin lesions include single or multiple red papules, plaques and nodules. It most commonly involves head and neck. Its etiology has not been determined. ALHE lesions are usually resistant to commonly suggested treatment methods including surgery. Recurrence of treated lesions is also common. Herein, we report a 38-year-old pregnant woman who presented with multiple red papules and nodules on her periauricular and occipital skin. Her lesions were confirmed to be ALHE after histopathological assessment.
Mohammad Reza Abbasi Sarcheshmeh, Azra Mohammadpanah Ardakan, Abolghasem Abbasi Sarcheshmeh,
Volume 7, Issue 3 (10-2016)
Abstract
Background and Aim: Demand for cosmetic surgeries is very high, especially in Iran and is affected by economic, social and psychological variables. The aim of this study was to compare the beliefs about appearance, irrational beliefs and presentation of body mass in individuals who demand and who do not demand cosmetic surgery procedures.
Methods: This cross-sectional study was conducted at the Shahid Sadoghi Savaneh va Soukhtegi Hospital in Yazd in 2014. The questionnaires were given to 150 individuals who were looking for cosmetic surgery, of which 126 completed questionnaires were considered eligible for analyses.
Results: There was a statistically significant difference in BMI and beliefs about appearance between who demand cosmetic surgery and who do not (P=0.022, P=0.017, respectively). Those who were looking for cosmetic surgery had more irrational beliefs in comparison with who were not (P=0.017). Mean of irrational beliefs was higher in females than males, but there was no statistically significant difference in the means of beliefs about appearance among women and men (P=0.131). Also, the mean of beliefs about appearance and irrational beliefs scores both were higher among single people than married ones (P=0.049 and P=0.045, respectively).
Conclusion: Gender, BMI and cognitive characteristics, especially irrational beliefs regarding attractiveness played significant roles in the those demanding cosmetic surgery. We suggest that people consult dietitians and psychology counselors before making decisions about undergoing a cosmetic surgery procedure.
Amir Hooshang Ehsani, Maryam Nasimi, Pedram Noormohammadpoor, Arghavan Azizpoor, Fatemeh Golpayegani,
Volume 8, Issue 1 (4-2017)
Abstract
Background and Aim: The aim of this study was to evaluate surgery approach outcomes in patients with squamous cell carcinoma (SCC) of lower lip.
Methods: We retrospectively analyzed medical records of patients that diagnosed with SCC of the lower lip at Razi hospital at Tehran University of Medical Sciences in a 5 year period. Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher’s exact tests to compare the variables.
Results: The age range of patients was 35 to 94 years (mean, 64.1 years; SD, 13.27 years), with a 5:1 male-female ratio. SCC of the lower lip occurred more frequently in patients older than 60 years. 62.1 % of the patients were addicted to cigarette and other tobacco compounds. It was noted
significant association between chronic solar exposure in the job’s environment and incidence of SCC in lower lip. Mean diameter of the tumor was 28.1 mm (range, 5 to 63 mm). Recurrence was detected in 17 patients (24.6%). Two patients (2.89%) died due to lower lip SCC in this series.
Conclusion: our study revealed that lower lip SCC is more prevalent in men and in eighth decade of life. As well, considering the low recurrence rate and high survival rate, surgery could be considered as an effective method of treatment.
Ahmad Jafari, Nafiseh Esmaeili, Shamsolmoulouk Najafi, Hanie Emami Razavi,
Volume 8, Issue 4 (1-2018)
Abstract
Background and Aim: Oral cancer as the most common cancer of head and neck region holds the eighth rank among all cancers in order of prevalence. More than 90% of oral cancers are of squamous cell carcinoma (SCC). The main objective of this study is the determination of the survival rate in patients with oral SCC and the factors influencing thereon.
Methods: In this study, 174 recorded cases of patients with oral SCC were evaluated. Required data on survival of patients were gathered by phone calls. Using software SPSS 20, the statistical analysis of data was carried out. The survival rate of the patients and the corresponding influential factors were analyzed by the Kaplan-Meier curves and Cox regression tests, respectively.
Results: 57.6% of the patients were male. The age of the patients ranged between 22-89 years with the average onset age of 61.5 years. The most common site of oral SCC was tongue. The overall five-year survival rate of the patients was 49.4%±0.05. The survival rate had a statistically significant relation with age of the patients and their treatment methods, including surgery or chemotherapy.
Conclusion: The prevalence of oral SCC is higher in men and overall survival rate decreases with increasing age of the patients. Due to the low survival rate of oral cancer patients, more attentions should be paid to this condition.
Salar Hooshyar, Shohreh Nafisi, Khadijeh Ashtari, Bita Mehravi,
Volume 8, Issue 4 (1-2018)
Abstract
Diseases of the skin can cause harm and emotional distress in patients. The desirable drug is one with least complications and most effectiveness. By prolongation of target exposure, drug effectiveness could be improved. There are several suggested solutions, including the use of chemical enhancers, electroporation, iontophoresis, and the use of nanoparticles as carriers of pharmaceutical agents. The use of various nanostructures, including liposomes, dendrimers, autosomes, and many mineral nanoparticles, have been proposed to prevent the limitations with conventional formulations. Topical drug delivery has many benefits, including using high concentrations of the drug and reducing systemic passage of medicament. Many skin products, such as Estrasorb, Diractin and Aczone are available in the market with new and different manufacturing techniques for more skin penetration.
This paper introduces new approaches to drug delivery, types of nanocomposites and methods for increasing the penetration of pharmaceutical agents in the skin. Various factors such as physicochemical properties and the size of nanoparticles, as well as the effects of manipulation on the surface of these particles, have been discussed.
Seyed Majid Ghazanfari, Maliheh Motevaselian, Roshanak Salari,
Volume 9, Issue 1 (4-2018)
Abstract
Itching is a mental feeling that elicits desire to scratch and results from stimulation of itch, pain or palpation receptors in the skin. In Iranian medicine, itching is referred as hekka. Several factors can cause this symptom. Various drugs are used to treat itching. They are sometimes costly and not readily available and have side effects. Given the time-consuming and cost-effective processes for the discovery of effective drugs, new strategies are needed to reduce processes time and costs. One of these strategies could be the use of previous experiences on medicinal plants and spices used in traditional medicine schools.
In this review, we searched the keyword "itching, pruritus" in three reference books of pharmacology of Iranian medicine, including The Canon of Medicine (Al-Qanon fi al-Tibb), Tohfe Momenin, and Makhzan- Al' Advieh and ened up with a list of 60 multifaceted plants effective in improvement of pruritus. The efficacy of each of them was categorized based of available evidence. Therefore, it is recommended to use the rich experience of Iranian traditional medicine in the production of new drugs for pruritus.
Negar Sadeghi, Alireza Moradi, Jafar Hasani, Shahram Mohammadkhani,
Volume 9, Issue 2 (7-2018)
Abstract
Background and Aim: The cosmetic surgery is one of the prevalent phenomenons in recent decades. Body image is a key factor for interest in cosmetic surgery, but body image is a multidimensional concept and all its dimensions should be studied. This study aimed to study cognitive, emotional and behavioral dimensions of body image in women interested in cosmetic surgery.
Methods: This study was a cross-sectional research with causal-comparative method. A sample of 600 female students, age 18 to 35 years, were selected from universities in Tehran by using multi-stage cluster random sampling methid, who completed a set of questionnaires including “Beliefs About Appearance Scale (BAAS)“, “Body Areas Satisfaction Scale (BASS)“, “the Body Image Coping Strategies Inventory (BICSI)“ and Acceptance of Cosmetic Surgery Scale (ACSS). The collected data were analyzed by multivariate analysis of variance (MANOVA).
Results: The students who were interested in cosmetic surgery got a higher score in components of body investment as cognitive dimension and body dissatisfaction as emotional dimension. Among the three behavioral components of body image, there was significant difference only in appearance fixing coping (P<0.0001) and there were no significant differences in acceptance and avoidant strategies between students.
Conclusion: All of the cognitive, emotional and behavioral dimensions of body image are important in cosmetic surgery, and women interested in cosmetic surgery not only had body dissatisfaction, but also had dysfunctional attitudes about appearance important in interpersonal relationships, personal achievement and self-concept, and used strategies based on body modification. These findings can be used in prevention and intervention programs.
Hamidreza Ahmadi Ashtiani, Alireza Firooz, Hossein Rastegar, Amirhosein Askaripour,
Volume 10, Issue 4 (1-2020)
Abstract
A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.
Sara Bahrainian, Atefeh Naeimifar, Saman Ahmad Nasrollahi,
Volume 11, Issue 2 (7-2020)
Abstract
Habits since the introduction of the first commercial antiperspirant and deodorant, the use of these products have played an increasing role in a person's personal care. This article studies the physiology of human perspiration and responsible compounds for body odor. It also describes the function, classification, and differences between antiperspirants and deodorants.
