Journal of

Postsurgical scars are of significant concern to both the patients and surgeons. Different laser systems have been used to accelerate and improve the healing process in surgical scars. Some studies have demonstrated the benefits of prophylactic laser application on pre-scars. It seems that using laser energy in the early phase of the healing process may produce changes in the physiology of wound healing toward a more fetal-like tissue regeneration and healing. Laser-Assisted Skin Healing (LASH) is a new approach in which laser irradiation is applied immediately after surgery in order to improve the resulting surgical scars. LASH produces controlled homogenous heating throughout the full thickness of the skin around the wound which accelerates wound healing without thermal damage to the tissue.

The purpose of this paper is to provide an overview of the available peer-reviewed research literature on the application of LASH, the in-vitro, animal and human studies and the suggested mechanisms of action. Further studies are necessary to optimize the best laser parameters especially according to different skin phototypes and  better understanding of the mechanisms of action.

Background and Aim: Lesions of the skin can impair its vital function to protect humans against external pathogens. Therefore, producing a suitable wound dressing to repair injuries is always one of the challenges of researchers. The present study aims to Synthesize a hydrogel film for wound dressing applications.

Methods: In this research, a hydrogel film of polyvinyl alcohol / hyaluronic acid / nano zinc oxide was fabricated for application as a wound dressing. For this purpose, three films with different percentages were prepared using the solvent casting method. The synthesized samples were characterized using FTIR, SEM, XRD, and tensile tests. 

Results: Evaluation of the morphology of the samples showed that the increase of zinc oxide nanoparticles led to porosity and growth of their size in the films. It was also characterized that the percentage of film elongation increased with increasing nanoparticles of zinc oxide and hyaluronic acid. The elongation percentage from the lowest amount of nano zinc oxide to the maximum (5, 10 and 15% of weight was 159%, 166%, and 230%, respectively. The MTT study indicated the cell viability above 80% in all three films.

Conclusion: A film containing 15% zinc oxide can be a suitable option for using in tissue engineering and wound dressing.