Mahmoud Farshchian, Akram Ansar, Mohammad Reza Sobhan, Saadat Torabian,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Psoriasis is a common chronic inflammatory skin disease. The risk factors of metabolic syndrome have been reported with greater frequency in patients with psoriasis. In this study, we aimed to evaluate these risk factors and compare them with normal population, as the control group.
Methods: In this case-control study, 55 patients with psoriasis were studied from 2011 to 2012 and 55 matched (for sex and age) persons were considered as control group. Age, gender, body mass index, systolic and diastolic blood pressures, smoking, alcohol consumption, type of disease, and blood levels of triglyceride, total cholesterol, LDL, HDL, and fasting sugar were evaluated in both case and control groups and compared.
Results: Our findings showed that levels of TG (P=0.005,OR: 1.02, 95%CI: 1.0-1.34) and LDL (P=0.03, OR: 1.04, 95%CI: 1.0-1.09), the frequency of smoking (P=0.02, OR: 2.2, 95%CI: 1.1-3.2), and the mean of systolic blood pressure (P=0.004, OR: 1.07, 95%CI: 1.02-1.33) were significantly higher in psoriatic patients, compare with control group.
Conclusion: Higher frequency of hypertension and lipid abnormalities in psoriatic patients may enhance the risk of cardiovascular diseases in them. Therefore, we recommend to check all patients with psoriasis, regardless of their disease severity, for serum lipid profiles and blood pressure. In addition, we strongly recommend giving up smoking, as a part of psoriasis treatment.
Nafiseh Esmaeili, Mansoureh Akhavan, Hossein Mortazavi, Abbas Karimi,
Volume 4, Issue 3 (9-2013)
Abstract
Background and Aim: Bullous pemphigoid is an acquired
autoimmune disease with subepidermal blisters commonly seen in the elderly over
60 years old. The exact survival rate of the patients with bullous pemphigoid
was not available in Iran. The aim of this study was to evaluate the risk
factors of 5-year mortality of bullous pemphigoid patients.
Methods: In this retrospective study, 66 bullous pemphigoid
patients referred to Razi hospital from 1986 to 2006 were studied. Age, sex,
consumed corticosteroid type, duration of hospitalization, and clinical form of
bullous pemphigoid, ESR and comorbidities were evaluated to determine the risk
factors associated with patients’ 5-year mortality rate.
Results: Forty-seven patients (71.2 %) had
5-year survival. The most common comorbidities were cardiovascular diseases
(28.8%), diabetes (15%) and chronic respiratory diseases (9%). There was a significant
relationship between the age and the 5-year survival rate, in other words
patients aged over 70 years had a less 5-year survival rate (P<0.001). There was no statistically
significant association with gender, the type of corticosteroid, the disease clinical
forms, duration of hospitalization or ESR and 5-year survival (P>0.05).
Conclusion: The current study found a
significant relationship between the age of the patients and 5-year survival. Larger
studies considering more potential risk factors and more appropriate designs
might help to estimate the survival rate of patients with bullous pemphigoid
more precisely.
