Mona Malekmohammadi, Hossein Abdol Tehrani, Nasser Aghdami,
Volume 2, Issue 3 (9-2011)
Abstract
Hyaluronic acid (HA), the main and most important constituent of extracellular matrix, is a glycosaminologycan with water-absorbing capacity found in large amount in growing and repairing tissues. One of the main causes of skin problems, particulary in aging skin, is HA deficiency. More than half of the body HA is in the skin and is necessary for the maintenance of internal matrix and several cellular functions. Filler gels containing HA are used to repair skin defects. As these substances are derived from animals and bacteria, not the human, may cause skin reactions and have short half-life. So efforts to maintain and/or increase HA secretion from skin fibroblasts are important in the prevention and treatment of skin aging.
Ala Ehsani, Amirhoushang Ehsani, Zahra Razavi, Mina Koohian Mohammadabadi, Mahshidsadat Ansari, Zeynab Aryanian, Pedram Nourmohammadpour, Amirmohammad Almasi, Amirhossein Rahimnia,
Volume 15, Issue 2 (8-2024)
Abstract
Background and aim: As the use of botulinum toxin to treat glabellar lines increases, particularly in Iran, where foreign products (e.g. Dysport) are relatively expensive, it becomes important to compare the efficacy, side effects, and duration of action of two locally produced botulinum toxin brands, Masport® and Dyston®. This study seeks to assess and compare the treatment results of these two medications.
Methods: In this cross-sectional, descriptive, retrospective study, the medical records of 81 patients who visited Razi Dermatology Hospital for the treatment of moderate to severe glabellar lines were reviewed. Data related to patient satisfaction, duration of action, and side effects of Masport® and Dyston® botulinum toxin were collected and analyzed via a questionnaire.
Results: The mean satisfaction score was 7 for the Dyston® group and 7.7 for the Masport® group, with no statistically significant difference between the two groups (P=0.142). Additionally, the mean duration of action was 3.5 months for Dyston® and 3.8 months for Masport®, with no significant difference observed. Headache was the most common side effect reported, with no other major adverse events noted. Furthermore, there was no statistically significant difference in the incidence of side effects between the two groups.
Conclusion: The findings of this study indicate that both Dyston® and Masport® have similar efficacy and safety profiles. The choice between them can be primarily based on cost and patient or physician preference rather than any significant therapeutic differences. Larger studies are recommended to further validate these findings.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (11-2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
