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Showing 3 results for Terbinafine
Use of terbinafine 250 mg in the treatment of ectothrix ringworm: A case report
Alireza Firooz, Azin Ayatollahi, Farnaz Valizade, Mansour Nassiri Kashani, Zaghrabeigom Moosavi, Mahsa Fattahi,
Volume 13, Issue 2 (8-2022)
Abstract
Background: Tinea capitis is the term used for scalp infections caused by dermatophyte fungi. Tinea capitis is common in children and is less common in adults.
Case Report: The case was a 9-year-old girl with itchy patches of alopecia on the. The patient had a cat as a pet. On examination, the patch of hair loss was itchy and the hair shaft was broken and scales were mild. In the examination with Wood's lamp and direct microscopic examination, the ectothrix infection was deagnised. According to the dermatologist's opinion, a terbinafine 50 mg was prescribed daily. However, no significant improvement was observed despite 4 weeks of terbinafine. As a result, the dose of terbinafine treatment was changed from 50 mg to 250 mg per day. After 6 weeks of treatment, the clinical manifestations of the patient improved significantly.
Conclusion: After ringworm is confirmed microscopically, choosing the most appropriate antifungal treatment depends on determining the fungal species by culture. Therefore, when choosing empiric antifungal agent therapy, a dose of 250 mg terbinafine may be a good choice for children.

Evaluate drug resistance pattern of dermatophyte species isolated from 27 patients referred to Razi Hospital
Safoura Shakoeinejad,
Volume 14, Issue 4 (2-2024)
Abstract

Background and Aim: In line with the increase in cases of dermatophytosis of the body and dermatophytosis of the groin, the cases of species resistant to antifungal drugs, especially terbinafine, are increasing. The present study was designed to investigate the drug resistance pattern of dermatophyte species isolated from 27 patients referred to Razi Skin Hospital.
 

Methods: Skin samples of patients were collected from the groin, buttock and body from the active margin of the lesion. Some of the sample was examined under the microscope for the presence of arthroconidia and fungal hyphae. Cultivation on Saburo dextrose agar 2% special medium with chloramphenicol and cyclohexamide was used to determine the primary identity of dermatophyte species, morphological characteristics were used. To accurately identify trichophytons isolated from the skin of patients by (molecular) genotyping method, ITS1 and ITS4 primers were used. Universal primers) were used. Microdilution broth drug sensitivity test was performed according to M38-3rd ed - CLSI protocol for dermatophyte isolates to terbinafine, itraconazole, fluconazole and voriconazole.
 

Results: 25 patients were infected with Trichophyton indotinae. 2 patients were infected with Trichophyton interdigitale. In the present study, 4.27 (14.81%) of the patients had antifungal resistance (1 μg/ml≤the minimum concentration of fungal growth inhibition for terbinafine).
 

Conclusion: Failure to perform mycological examinations before initiating treatment can result in misdiagnosis.  Do not use the antifungal susceptibility test lead to  challenging to manage treatment-refractory cases. inadequate and inappropriate treatment combinations can increase the number of resistant species worldwide.


Increasing the drug resistante dermatophytes, the importance of antifungal susceptibility testing and its methods
Azin Ayatollahi, Pegah Tamimi, Aliasghar Ghaderi, Mahsa Fattahi,
Volume 14, Issue 4 (2-2024)
Abstract
Recently, the cases of dermatophytosis have increased sharply, which is associated with frequent reports of chronic cases of the disease, uncommon skin manifestations, and treatment failure. Cases of emergence of resistant species in other geographical areas such as Denmark, Switzerland, and China, Belgium, Germany, Japan, Iran, Finland, Switzerland, France, Iraq and Bahrain are also known. Antifungal drug susceptibility testing for dermatophyte species has not yet been standardized. Antifungal Susceptibility Tests (AFST) are used to determine the minimum growth inhibitory concentration (MIC) of a specific drug in laboratory conditions with the aim of predicting whether a patient will respond to standard antifungal treatment or not. In the continuation of this article, we gave an overview of the antifungal sensitivity test, including its strengths and weaknesses and its role in helping to make therapeutic decisions.
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