Journal of

Toxic epidermal necrolysis (TEN) is a server, life-threatening drug-induced mucocutaneous eruption that rarely affects scalp. There has been limited number of cases of TEN arising in patients receiving radiation therapy plus anticonvulsants.Here, we report a case of TEN secondary to anticonvulsant and radiation therapy. An unusual aspect shared by our patient as well as the other reported cases is that the eruption always begins at the site of recent radiation therapy. In this report, we discuss the possible hypotheses for this phenomenon.

N-acetylcysteine (NAC) is the acetylated metabolite of cysteine and is approved by the Food and Drug Administration (FDA) for treating acetaminophen toxicity. By boosting glutathione, NAC acts as an antioxidant and through replenishing glutathione, it can also prevent paracetamol toxicity. From the other hand, NAC has mucolytic and antiinflammatory effects and also is a glutamate precursor and therefore can be used in a variety of diseases. Regarding the various pharmacological effects of NAC and its low rate of adverse events, NAC has attracted increasing interest for a range of indications during the recent years. Here, the possible applications of this drug in dermatology are reviewed.