Showing 4 results for Trichophyton
Afsarolmoluk Hadadian, Azin Ayatollahi, Akram Miraminmohammadi, Mahshid Shahrzadkavkani, Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi,
Volume 12, Issue 3 (11-2021)
Abstract
Introduction: Dermatophytosis are micro-organisms which can lead to skin diseases. In rare occasions they can have atypical skin manifestations, which could result in delay in diagnosis.
Case Report: A 20-year-old Iranian boy was referred to our center with a 5-month history of circular, symmetrical, itchy crusted skin lesions on his groin. Direct microscopy, culture test and PCR-sequencing of ITS regions of the rDNA gene were conducted and showed T. indotinea as the causative agent. Based on antifungal susceptibility test oral pulse therapy with itraconazole 100 mg twice daily for 1 week combined with topical clotrimazole cream for 1 month was initiated, which cleared the lesions.
Conclusion: This case report is of significance since T. indotinea produces atypical skin lesions, as well as, multidrug resistance to antifungal agents.
Safoura Shakoeinejad,
Volume 14, Issue 4 (2-2024)
Abstract
Background and Aim: In line with the increase in cases of dermatophytosis of the body and dermatophytosis of the groin, the cases of species resistant to antifungal drugs, especially terbinafine, are increasing. The present study was designed to investigate the drug resistance pattern of dermatophyte species isolated from 27 patients referred to Razi Skin Hospital.
Methods: Skin samples of patients were collected from the groin, buttock and body from the active margin of the lesion. Some of the sample was examined under the microscope for the presence of arthroconidia and fungal hyphae. Cultivation on Saburo dextrose agar 2% special medium with chloramphenicol and cyclohexamide was used to determine the primary identity of dermatophyte species, morphological characteristics were used. To accurately identify trichophytons isolated from the skin of patients by (molecular) genotyping method, ITS1 and ITS4 primers were used. Universal primers) were used. Microdilution broth drug sensitivity test was performed according to M38-3rd ed - CLSI protocol for dermatophyte isolates to terbinafine, itraconazole, fluconazole and voriconazole.
Results: 25 patients were infected with Trichophyton indotinae. 2 patients were infected with Trichophyton interdigitale. In the present study, 4.27 (14.81%) of the patients had antifungal resistance (1 μg/ml≤the minimum concentration of fungal growth inhibition for terbinafine).
Conclusion: Failure to perform mycological examinations before initiating treatment can result in misdiagnosis. Do not use the antifungal susceptibility test lead to challenging to manage treatment-refractory cases. inadequate and inappropriate treatment combinations can increase the number of resistant species worldwide.
Parham Tamimi, Pegah Tamimi,
Volume 16, Issue 1 (5-2025)
Abstract
Kerion Celsi is a severe inflammatory fungal infection of the scalp that affects deeper layers of the skin. While it is uncommon in newborns, its incidence increases in children aged 3 years and older. It typically presents with swelling, spongy or boggy lesions, tenderness, hair loss (alopecia), and purulent discharge. Secondary bacterial infections are frequently seen following skin breakdown or maceration. Systemic symptoms may include enlarged lymph nodes, fever, and in very rare instances, fungal bloodstream infection (fungemia). Hypersensitivity reactions (Id reactions) can also occur. Diagnosis is guided by clinical evaluation, including patient history and physical examination, and must be confirmed using microscopy, fungal culture, and molecular diagnostic techniques. The most commonly isolated pathogens are anthropophilic Trichophyton tonsurans and zoophilic Microsporum canis. In contrast, geophilic fungi and molds are rarely implicated. Treatment is non-surgical, involving a combination of systemic and topical antifungal agents, with systemic antibiotics added when bacterial coinfection is suspected. Surgery should be avoided. Early and adequate therapy is critical to prevent permanent scarring and hair loss. The primary differential diagnosis includes bacterial infections of the skin and soft tissue.
Azin Ayatollahi, Mahsa Fattahi,
Volume 16, Issue 1 (5-2025)
Abstract
Dermatophytes are keratinophilic fungi responsible for common and benign infections worldwide. However, in immunocompromised patients, they may lead to rare and severe diseases. Severe forms include widespread and/or invasive dermatophytosis, such as deep dermatophytosis and Majocchi’s granuloma. These cases have been reported in individuals with primary immunodeficiencies (such as autosomal recessive CARD9 deficiency) or acquired immunodeficiencies (such as solid organ transplantation, autoimmune diseases treated with immunosuppressive therapies, or HIV infection). The clinical manifestations of these infections are non-specific. Lymph node and organ involvement may also occur. Diagnosis requires mycological and histopathological evidence. There is no consensus on treatment. Systemic antifungal agents, such as terbinafine and azoles (e.g., itraconazole or posaconazole), are effective. However, the long-term outcome and management depend on the site and extent of the infection and the type of underlying immunodeficiency.
