Journal of

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Background and Aim: Diabetic neuropathy occurs in about 50% of individuals with long-standing type 1 and type 2 diabetes mellitus. The aim of the study was to detect sensory neuropathy in diabetic patients at risk for foot ulceration, using monofilament and neuropathic symptoms in Diabetes clinic of Kashan University of Medical Sciences from 2008 to 2010.

Methods: Three-hundred and fifty-two diabetic patients were enrolled in this cross-sectional study. Firstly patients were surveyed with a questionnaire concerning their subjective symptoms. The neuropathic symptoms were assessed using a quantitative neuropathy symptom score. Then the patients were examined by 5.07/10g monofilament. Data description and analysis were performed by reporting mean ± standard deviations, proportions, odds ratios (OR) and 95% confidence interval (95% CI) and conducting chi square and kappa tests. 

Results: 15.6% of patients had sensory neuropathy using monofilament test. 19.4% of men and 14.3% of women had neuropathy (OR=1.4, P=0.24). The mean duration of diabetes in patients with neuropathy was longer than patients without neuropathy (9.96 vs 9.68 year, P>0.05). 72.7% of patients with history of foot ulcer had neuropathy (OR=16.6, P<0.001). According to neuropathic symptoms 17.6% of patients had no neuropathy, 12.8% had mild neuropathy, 41.8% had moderate neuropathy and 27.8% had severe neuropathy.

Conclusion: Screening with monofilament test is necessary for all diabetic patients to prevent diabetic foot ulcer development, without considering neuropathic symptom

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A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.