Showing 16 results for Vitiligo
Masoud Maleki, Alireza Assari, Ahmadreza Taheri, Mohammad Ebrahimirad,
Volume 2, Issue 1 (3-2011)
Abstract
Background and Aim: Vitiligo is a common skin disorder that presents as depigmented patchs and associated with psychosocial morbidity. Photochemotherapy with methoxsalen plus ultraviolet A (PUVA) is an effective and commonly used modality in treatment of vitiligo and is available in Khorasan Province since more than ten years ago.
Methods: This uncontrolled clinical trial included patients with vitiligo referred to phototherapy center in Emam Reza Hospital in Mashhad during 1998-1999. Treatment was done topically on patients with involvement less than 2% of the body area and systemic in cases with involvement more than that. Data including improvement rate and side effects were analyzed by SPSS software version 11.5.
Results: One-hundred and thirty-five patients, 79 female and 56 male, were enrolled. One-hundred and twenty-six patients were treated systemically and 9 patients underwent topical therapy. Complete (100%) repigmentation was observed in one patient. Repigmentation of 80-99%, 60-79%, 40-59%, 20-39% and less than 20% were observed in 53, 43, 12, 6 and 20 patients respectively. Results were significantly better in generalized vitiligo, face involvement, and cases whom recieved more than 200 treatment sessions, but there was not significant relationship between improvement and patients' age, family history, the first involved area, beginning time of repigmentation, the observed interval between initiation of treatment and disorder appearance, and skin type. Common side effects were pruritus (69.6%), erythema (52.6%), nausea and vomiting (28.9%), and headache (17.8%).
Conclusion: PUVA therapy is an effective and safe treatment in patients with vitiligo, and has good results in nonsegmental vitiligo and facial involvement.
Mahsa Ghajarzadeh, Shahrbanoo Kheirkhah, Maryam Ghyiasi,
Volume 2, Issue 4 (12-2011)
Abstract
Background and Aim: Vitiligo is a chronic skin disease which is characterized by depigmented patches due to loss of melanocytes. On contrary of low physical impairment, vitiligo causes a lot of cosmetic problems which can lead to psychological problems. The aim of this study was to evaluate the quality of life and depression in Iranian patients with vitiligo, who were referred to Razi Hospital in 2009 and 2010.
Methods: From January 2009 until January 2010 one hundred vitiligo patients were randomly selected from outpatient clinic of Razi Hospital and asked to answer to the following valid and reliable instruments Beck Depression Inventory (BDI), SF-36 and Dermatology Life Quality Index (DLQI).
Results: The mean age ± standard deviation of the participants was 28.9±11.5 years and mean scores of BDI,SF-36 and DLQI of all patients were 15.9±11.8, 63.8±19.4 and 8.4±6.9 respectively. There was a significant relationship between DLQI scores and the duration of the disease (r=0.3, P<0.001) while there was no significant relationship between DLQI scores and age (r=0.1, P=0.2).
Conclusion: Evaluation of quality of life and depression in patients with vitiligo and consequences of the disease on patients' lives should be considered.
Rezvan Talaee, Mohammadreza Moayeri, Tahereh Mazuchi, Seyed Alireza Moravveji, Mohaddese Ardestani,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Quality of life is a broad concept that reflects an individual’s perspective on the level of life satisfaction experienced in a variety of situations including housing, recreation, environmental conditions, health and job. In this way it is a subjective measure that is affected by factors well beyond health status. To evaluate quality of life in patients with common pigmentation disorders such as vitiligo, melasma, and freckles refer to dermatologic clinics of Kashan University of medical sciences during 2010 and 2011.
Methods: In this cross sectional study, 142 patients with pigmentation disorders, older than 18 years old filled out Dermatology Life Quality Index (DLQI) questionnaire. DLQI questionnaire includes 10 questions regarding feelings, daily activities, leisure, job and education, personal relationship and treatment. Scoring was performed according to Finlay's guidelines. The data were analyzed with t, ANOVA and Pearson correlation tests. The higher the score, the greater the impairment of quality of life.
Results: The mean DLQI score was 5.64 (±5.03). The mean DLQI score in vitiligo was higher than other diseases. In this study score of quality of life in women, patients younger than 25 years old, patients with lesions on exposed areas, and single patients was higher than others, but there was not any significant relationship between quality of life and duration of disease, job, education level and place of residence.
Conclusion: This study showed that skin pigmentation disorders had a significant impact on all aspects of the quality of life, especially on socio-psychological aspect. Therefore, dermatologists should pay attention to the psychological effects of those diseases and try to decrease their extensions and disfigurating effects by various treatment modalities.
Rooh-O-Allah Fadaei, Alireza Firooz,
Volume 3, Issue 3 (9-2012)
Abstract
Clinical practice guidelines are the most important and valid guidelines for treatment of diseases, and are developed through experts consensus on a subject, considering the highest available evidence (systematic reviews, metaanalyses, and randomized controlled trials). We briefly review the latest evidence-based guideline for the treatment of vitiligo provided by European Dermatology Forum.
Ameneh Yazdanfar, Mohammadreza Ahmadpanah, Zohre Kheradmand,
Volume 5, Issue 1 (3-2014)
Abstract
Background and Aim: Vitiligo and acne are common chronic skin diseases with cosmetic impacts affecting various aspects of quality of life. This research was done to study the quality of life in these patients and their related factors.
Methods: This cross-sectinal study was carried out on 132 patients with vitiligo and 136 patients with acne. The patients were asked to answer questionnaires including questions about their demographic and clinical information as well as questionnaire of Dermatology Life Quality Index (DLQI). SpSS version 16 was used to statistically describe and test the data.
Results: The mean±standard deviation (SD) ages of patients with vitiligo and acne, were 22.8±5.7 and 28.9±11.5 years, respectively. The proportions of female patients with vitiligo and acne were 54.5% and 83.8%, respectively. Patients were matched for age and gender. There was no statically significant differrence between the mean DLQI score and age, martial status, occupation, residence, education, age of onset of disease in neither group. Patients with more chronic vitiligo experienced significantly impaired quality of life (P=0.008). A statistically differrence was found between mean DLQI scores and clinical forms of vitiligo. The mean scores of patients with generalized type was higher than those with localized forms (P=0.032). Patients with severe acne experienced significantly impaired quality of life (P=0.002). The mean DLQI scores in vitiligo and acne were 6.75 and 7.05, respectively, but this differrence was not statistically significant (P=0.08). A statistically significant difference was found in two subgroup: in symptoms and feelings (P=0.002) and interpersonal relationships (P=0.02).
Conclusion: The quality of lifves of patients were affecteded by the type of disease, its severity and its duration in both groups.
Lida Bahrami, Hamze Ahmadian, Gholamreza Eshghi,
Volume 5, Issue 3 (10-2014)
Abstract
Background and Aim: Vitiligo is a common skin disease and it is important to recognize and manage its social and psychological consequences. The aim of this study was to investigate the relationship between illness perception, depression and quality of life among vitiligo patients referred to the skin clinic of Farshchian Hospital in Hamedan.
Methods: This cross sectional study was conducted on the patients with vitiligo referred to the skin clinic of Farshchian Hospital during the first quarter of 2014. The study sample consisted of 100 patients (32 male and 68 female patients) with vitiligo who were selected using convenience sampling. Measurement tools included the Revised Illness Perception Questionnaire (IPQ-R), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Beck Depression Inventory-II (BDI-II). The data were analyzed using Pearson's correlation test.
Results: Illness perception have significant relationship with depression and quality of life in vitiligo patients. There was a significant difference in positive (P=0.031) and negative (P=0.002) illness perception scores between male and female vitiligo patients. Also, environmental dimension of quality of life in vitiligo patients was significantly different between men and women (P=0.031).
Conclusion: Evaluation of quality of life and depression in patients with vitiligo to reduce the adverse consequences of the disesase on patients' lives is recommended.
Mohamadreza Ranjkesh, Shahla Babaeinejad, Marzie Aghazade, Afsane Radmehr, Behzad Anoush, Danial Fadaei Fooladi,
Volume 6, Issue 3 (10-2015)
Abstract
Background and Aim: Vitiligo is an skin condition that results in the skin depigmentation. The implementation of a basal cell layer suspension is a novel treatment in cases with recalcitrant vitiligo. In this study, the efficacy of topical calcipotriol on the implementation site with basal cell layer suspension versus basal cell layer suspension application alone was compared.
Methods: In this randomized, controlled clinical trial, 20 patients with recalcitrant vitiligo were randomly allocated in two 10-patient groups, undergoing the implementation of basal cell layer suspension alone (controls) or along with daily application of topical calcipotriol (intervention group). Results and possible complications were compared between the two groups 6 months after initiation of the treatment.
Results: Six months after initiation of the study, 2 patients (20%) in the control group had poor responses, and 8 patients (80%) had moderate/good responses. In the intervention group, 1 patient (10%) showed poor response, and 9 patients (90%) showed moderate/good responses (P>0.05). Complications were trivial and self-limiting.
Conclusion: Although topical application of calcipotriol did not signigicantly change the primary outcome of the study, it was associated with better results and no major side effects.
Zahra Karimi, Anahita Khodabakhshi Koolaee, Amir Houshang Ehsani,
Volume 7, Issue 3 (10-2016)
Abstract
ackground and Aim: Vitiligo is a chronic skin disease which manifests with depigmented patches as a result of absence of skin melanocytes. Vitiligo results in beauty problems which could cause mental disorders. The purpose of this research was to compare the tendency to suicide and stress in patients with vitiligo with those without any skin disease.
Methods: For conducting this research, 30 patients with vitiligo who were referred to the Behsima Skin and Laser Clinic in Tehran during 2016 were recruited. Data were collected using Beck suicide scale ideation and Kohen stress questionnaires. Thirty demographically-matched individuals without active skin disease over the past six months were recruited into the study as the control group.
Results: Mean±standard deviation (SD) of Beck suicide scale ideation (BSSI) score in patients with vitiligo was 3.67±1.33, significantly higher than 0.37±0.17 in the control group (P=0.02). Mean scores of stress in vitiligo patients was 28.33±9.20, which was also higher than the control group mean, 21.77±8.19 (P=0.005).
Conclusion: Patients with vitiligo had more suicide ideation and stress than normal population. So, in taking care and treating in vitiligo patients, a special attention to the psychological effects of disease on the lives of the patients is recommended.
Marjan Entezami, Bahareh Malek Afzali, Roghayeh Jebreili, Bita Shahbazzadegan,
Volume 7, Issue 4 (1-2017)
Abstract
Background and Aim: Vitiligo is a common pigmentary disorder that melanocytes are destroyed. Treatment of vitiligo depends on the extent of the disease and its distribution pattern. The aim of this study was to compare the efficacy of PUVA and NBUVB in patients with vitiligo.
Methods: A clinical trial has been performed on 60 patients with vitiligo referred to Bouali hospital and Mehrgan laser center in 1392 and treated with UVB and PUVA therapy methods. In first group treated with PUVA, oral tablets containing 8-methoxypsoralen were taken 3 hours before phototherapy twice a week. The second group was treated with NBUVB twice a week.
Results: In patients treated with PUVA, 40% and in patients treated with NBUVB, 43.3% were male. Seventeen (56.7%) of patients treated with PUVA had generalized vitiligo, 30% of them had segmental Vitiligo and 13.3% had focal Vitiligo. Seventeen (56.7%) patients that were treated with NBUVB generalized vitiligo, 30% had segmental and 10% had focal vitiligo. Repigmentation was significantly higher in patients treated with NBUVB than PUVA 3 and 6 months after initiation of treatment (P<0.05).
Conclusion: NBUVB is superior to PUVA in treatment complications and its recovery rate was acceptable.
Elham Zareie, Roodabeh Bahramsoltani, Parisa Heidari, Leyla Shirbeigi,
Volume 8, Issue 2 (7-2017)
Abstract
Vitiligo is a common disorder in skin pigmentation and has an important role in patient’s quality of life. It may also cause severe emotional stress which makes its treatment necessary. As conventional therapeutic strategies are ineffective, there is an increasing tendency to use complementary medicine in the management of vitiligo. This article has been written with the aim of describing Iranian Traditional Medicine (ITM) approach to vitiligo mechanisms, prognosis and natural therapeutics. It is a product of a library study in the main ITM references and also related articles using mentioned keywords.
According to ITM text books human body consists of four substantial humors, each has a very specific quality and quantity. Any excess or deficit of these humors may result in different disorders. Changing in phlegm humor and also improper function of “expulsive faculty” are the main causes of vitiligo from the viewpoint of ITM.
Hamid Kharatzadeh, Abolfazl Mohammadi, Fariba Jaffary, Sayed Mohsen Hoseini,
Volume 9, Issue 2 (7-2018)
Abstract
Background and Aim: Vitiligo is a prevalent depigmentaling skin disorder, which has a great impact on the quality of life of patients. The purpose of this study was to investigate the relationship of quality of life of these patients with self-compassion and experiential avoidance.
Methods: In this analytical cross-sectional study, Self-Compassion Scale (SCS), Second Edition of Acceptance and Action Questionnaire (AAQ-II), and Vitiligo Quality of Life Index (VitiQoL) were completed by 105 patients with vitiligo (49.5% male) who were selected through available sampling method. The data were analyzed using descriptive statistics, Pearson correlation coefficient, t-test, ANOVA and covariance analysis.
Results: The average of quality of life score of the participants in the study was 32.14. There was a significant relationship (P<0.01) of the quality of life scores with the scores of experiential avoidance (R=0.28), self-judgment (R=0.36), isolation (R=0.52) and extreme identification (R=0.42). After removing the confounding effect of the variables on each other, the relationship of quality of life score with the location of the lesion (P=0.04) and isolation score (P=0.001) was significant.
Conclusion: Self-compassion and experiential avoidance play an important role in the quality of life of patients with vitiligo, and targeting these two components through psychological treatments can be effective in improving the quality of life of these patients.
Rahele Ahmadi, Ilnaz Sajjadian, Fariba Jaffari,
Volume 10, Issue 1 (4-2019)
Abstract
Background and Aim: Vitiligo is a depigmenting skin disorder, which has a great impact on the psyches of patients. The present study aimed at investigating the effectiveness of compassion-based treatment on anxiety, depression, and suicidal ideation of women with vitiligo.
Methods: This study was designed as a pre-test and post-test semi-experimental with a one-month follow-up and control group. Thirty patients of all vitiligo women (n=80) referring to Skin Diseases and Leishmaniasis Research Center (SDLRC) during 2016-2017 (n=80) were selected for this study and randomized in 2 groups: all participants were assessed for anxiety and depression using Hospital Anxiety and Depression Scale (HADS), Zigmond and Smith (1983), suicidal through Beck Scale for Suicide Ideation (BSS), (1997) before intervention, at the end and one month after intervention. The experimental group attended in 8 consecutive 60-minute session group - based compassion - focused therapy (CFT, Gilbert and Neff therapeutic Package 2009) biweekly. Control group did not receive any intervention until the end of the follow-up phase. Repeated measure analysis of variance was used for data analysis.
Results: The results showed that compassion-focused therapy was effective on anxiety, depression, suicide ideation compared to control group.
Conclusion: According to the results of this research, compassion-based therapy has been effective in reducing anxiety, depression, and suicidal ideation.
Shirin Irani,
Volume 10, Issue 2 (8-2019)
Abstract
Background and Aim: Schema modes include specific schemata and coping styles which are activated in emotional situations. They create formation of behavioral patterns compatible with their own schemata. The purpose of this study was to predict the quality of life in vitiligo patients according to their schema modes.
Methods: In this descriptive-correlational study,170 vitiligo patients were selected by simple random sampling method. They filled Schema Modes Inventory and brief form of the World Health Organization`s Quality of Life questionnaire. The data were analyzed using descriptive statistics, Pearson correlation coefficient, and stepwise regression.
Results: The results of the analysis of the Pearson correlation coefficient revealed that quality of life was related to all schema modes except detached self-soother mode. Happy child and healthy adult schema modes had a significant positive relationship with quality of life, while the other schema modes (except detached self-soother) had a significant negative relationship with quality of life in vitiligo patients. Also, the results of stepwise regression showed that vulnerable child, detached protector, compliant surrender and happy child schema modes had the strongest effect in predicting the quality of life, respectively.
Conclusion: Regarding the importance of the role of schema modes in quality of life in vitiligo patients, offering psychotherapies such as schema therapy seems necessary.
Shima Kalavani, Samaneh Zolghadri,
Volume 11, Issue 3 (10-2020)
Abstract
Background and Aim: Vitiligo vulgaris is an acquired, chronic skin and hair condition characterized clinically by loss of melanin, which, if untreated, is typically progressive and irreversible. The aim of the present study was to identify potential genes involved in the pathogenesis of vitiligo.
Methods: One dataset of mRNA expression in patients with vitiligo (GSE65127) were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified using R package. The interactive information among DEGs and the PPI network was obtained using the STRING online database. Functional and pathway enrichment analyses of these DEGs were performed from EnrichR and hub genes and modules of the PPI network were visualized and analyzed by Gephi.
Results: Compared with the normal control group, ten upregulated genes (P<0.05) were identified including TP53, HNRNPA2, SRSF1, PTEN, CDC42, EGFR, EIF4A1, MYB, HNRNPH1, SF381, and CDH2, LEP, KIT, GRIA2, SPP1, NRXN1, RUNX2, PDGFRB, NES, MYH11 as downregulated genes. Up-regulated DEGs were enriched in three pathways including prostate cancer, epithelial cell signaling in helicobacter pylori infection and melanoma pathways. Down-regulated DEGs were enriched in three pathways including melanogenesis, Renin secretion and pancreatic secretion pathways.
Conclusion: Identifying DEGs in vitiligo may contribute to our understanding of its pathogenesis, and such DEGs may be used as drug targets for treatment.
Misagh Norouzi, Hamidtaher Neshat Doust, Fariba Jafari,
Volume 14, Issue 2 (8-2023)
Abstract
Background and Aim: The aim of this study was to determine the effectiveness of psychotherapy based on improving quality of life on depression and self-esteem in women with vitiligo.
Methods: The present study was a quasi-experimental study (Pre-test - post-test with follow-up and control group). The statistical population of this study included all women with vitiligo skin disease referred to Isfahan Dermatology and Leishmaniasis Research Center , among which, 20 people were selected by available sampling method and randomly assigned to experimental and control groups (10 people for each group). Both groups completed Beck Depression Inventory (1996) and Rosenberg Self-Esteem (1965) Questionnaires as a pre-test and after completing eight sessions of psychotherapy based on improving quality of life (one 90-minute session per week for eight weeks), the post-test was performed again and one month later for the control and experimental groups. The collected data were analyzed using repeated measures analysis of variance in SPSS 23 software.
Results: Based on the findings of repeated measures analysis of variance, it was found that psychotherapy based on improving quality of life reduced the average depression scores and increased the self-esteem of women with vitiligo.
Conclusion: Considering that psychotherapy based on improving the quality of life has an effect on depression and self-esteem in women with vitiligo, so teaching this therapeutic approach is recommended as an effective intervention method to reduce depression and improve the self-esteem of women with vitiligo.
Parvaneh Delkabadi, Sara Hashemi,
Volume 15, Issue 2 (8-2024)
Abstract
ackground and Aim: Vitiligo, as one of the most common skin pigment production disorders has significant psycho-social consequences for patients, so it is important to discover the variables affecting mental health in these patients. present study aims to consider mediating role of internalized shame in the relationship between cognitive avoidance and interpersonal difficulties in predicting the quality of life of vitiligo patients.
Methods: The current research was of a descriptive correlation type. The statistical population of the research consisted of all the people referred to Razi Hospital in Tehran who were suffering from vitiligo. 170 people purposefully selected based on the inclusion criteria. In this research, Sexton and Dagas cognitive avoidance, Barkham's interpersonal problems, World Health Organization's quality of life, and Cook's internalized shame questionnaires were used. Data analysis was done by Pearson correlation coefficient test, regression analysis and path analysis using SPSS 26 and PLS software.
Results: The results showed that the internal shame in the relationship between interpersonal problems and quality of life was recognized as a relative mediating variable. The path of cognitive avoidance with quality of life and internal shame as a mediating variable was not significant with a significance level of less than 0.05.
Conclusion: Mental health professionals can play an important role by considering the role of internal shame in helping vitiligo patients to overcome challenges, improve their mental health and well-being.
