Journal of Dental Medicine

Since 1800, it is known that fungican invade human tissues and from 1900, there is a great deal of information about incidence and epidemiology and geographic distribution and fungal infections.Because of increased incidence of fungal infections on recent years and importance of these organisms in producing of systemic and muco- cutaneous diseases, many investigations are performed about these fungal.22patients was evaluated immunological)' and it was revealed that, 77% of patients had increased immunoglubin serum level that was denoted of a normal B. lymphocytes function. As a matter of fact, both immune system are involved in anti- candidia defence, humoral immunity inhibits the penetration of Candida into mucous membranes, skin and internal organs.