Volume 36 -
jdm 2023, 36 - : 140-166 |
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Noohi P, Abdekhodaie M J, Nekoofar M H, Dummer P M. Overview of recent advances in pulp/dentine complex tissue engineering. jdm 2023; 36 : 15
URL: http://jdm.tums.ac.ir/article-1-6211-en.html
URL: http://jdm.tums.ac.ir/article-1-6211-en.html
1- Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
2- Professor, Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran; Environmental and Applied Science Management, Yeates School of Graduate Studies, Toronto Metropolitan University, Toronto, Canada
3- Associate Professor, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Endodontic, Bahçeşehir University School of Dentistry, Istanbul, Turkey
4- School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK
2- Professor, Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran; Environmental and Applied Science Management, Yeates School of Graduate Studies, Toronto Metropolitan University, Toronto, Canada
3- Associate Professor, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Endodontic, Bahçeşehir University School of Dentistry, Istanbul, Turkey
4- School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK
Abstract: (479 Views)
Background and Aims: Pulp necrosis in immature teeth disrupts root development and makes the teeth susceptible to fracture. Regenerative endodontics is a relatively new modality of treatment where the necrotic pulp is replaced with newly formed healthy tissue which has normal functionality. Many clinical reports have demonstrated the potential of this strategy to induce root maturation and apical closure. However, clinical outcomes are patient-dependent and unpredictable. Developing predictable protocols can be achieved through the interplay of three basic elements of tissue engineering, namely, scaffolds, stem cells, and signaling molecules. Furthermore, the clinical success of this treatment is influenced by both the method of preparing the inner space of the root and the type of biomaterial utilized in the coronal part. In this review, we discuss recent advances in tissue engineering-based strategies for regeneration of the pulp/dentine complex along with their advantages and limitations.
Article number: 15
Keywords: Regenerative endodontics, Tissue engineering, Pulp/dentin complex, Stem cell, Signaling molecule, Scaffold
Type of Study: review article |
Subject:
endodontics
Received: 2023/05/16 | Accepted: 2023/11/27 | Published: 2023/05/31
Received: 2023/05/16 | Accepted: 2023/11/27 | Published: 2023/05/31
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