Journal of Dental Medicine

This review was focused on investigations in the relationship between human leukocyte antigens and periodontal disease. Several studies have looked for relationship between HLA phenotypes and early onset periodontitis (EOP). There have also been reports on both positive and negative relationship between specific HLA antigens and periodontal disease. Positive relationship has been reported among HLA-A1, A9, A24, A28, A33, B15, B22, B35, B44, C4, DR2, DR4, DR7, DR53, DRB1, DQ3 and DQB1 antigens and different forms of EOP. Several studies have reported negative relationship with HLA-A2, A5, A10, A28, A68, B5, DR2 and DR6. Two antigens that appear to be more related to EOP are HLA-A9 and DR4. Evidence suggests that genes in this area are not genes with major effect for early-onset periodontal diseases. It is possible that genes in the MHC region of chromosome 6 may function as modifying genes that affect clinical expression of periodontal disease. However, additional documents are needed to evaluate the relationship of HLA antigens with periodontal disease. These documents should have adequate controls, which account for racial differences in HLA type and well-defined patient groups whose state of disease is described

There are many researches evaluation different methods for covering the root surface. In the most of these studies, type I and II of Miller treatment had been searched. The purpose of this study was a comparison between connective tissue graft (CTG) and guided tissue regeneration (GTR) with a collagen membrane in the treatment of gingival recession defects (Miller class III). Six patients, each contributing a pair of Miller class III buccal gingival recessions, were treated. The clinical measurements were obtained at baseline and 1,2,4,6,12,18 months after surgery. Statistical analysis were performed using paired t-test between periods (baseline versus 6 months and baseline versus 18 months) within each treatment group and also between treatment groups before treatment and 6, 12 and 18 months after the treatment. The treatments were compared by a triple analysis of variance along the time (treatment, patient, time). Both CTG and GTR with a bioabsorbable membrane demonstrated significant clinical and esthetic improvement for gingival recession coverage. The CTG and GTR procedures had mean root coverage of 55% and 47.5% respectively, in the end of study. The CTG group was statistically better than GTR for recession depth, recession width and keratinized tissue width. Also, passing the time (18 months) as a distinct factor of treatment procedures was effective in increasing of clinical attachment level and keratinized tissue width.