Journal of Dental Medicine

Normal 0 false false false EN-US X-NONE AR-SA Cytokines are glycoproteins produced  specifically by lymphocytes, macrophages, monocytes and many other cells. In fact, They act nonspecifically. Cytokines are not immunoglubolins and unlike them, have not high molecular weight. They regulate immuneresponse as well as in diagnosis and treatment of diseases. Cytokines role  in periodontal diseases as well as identifying them in the pathogenesis of some dental and oral diseases and bone loss process is an important issue in dentistry. Hence, this article presents cytokine's role and developments of immunology science in dentistry.

 

Normal 0 false false false EN-US X-NONE AR-SA Recurrent aphthous is a painful condition with 10-12% prevalence in the world. Considerable evidence are existed about the relationship between cellular immune response and recurrent aphthous .In this regard, present study carried out to analyze lymphocyte phenotype in patients with aphthous stomatitis in both active and remission phases of the disease . The results showed CD4 T-lymphocytes are decreased during active phase while there were insignificant changes in CD3 and CD8 T-lymphocytes count compared to normal population. CD4/CD8 ratio was also decreased (P≤0.05). CD16 killer lymphocytes and CD19 cells were increased significantly in active phase of the disease (P≤0.05).

Background and Aim: A strong causal relationship exists between cigarette smoking and development of oral squamous cell carcinoma, so oral screening using exfoliative cytology has been recommended to facilitate the early diagnosis of cellular alterations in oral mucosa and silver staining (AgNOR technique) has been proven to be of value in the detection of incipient cellular alterations. The purpose of this study was to compare the argyrophilic nucleolar regions (AgNORs) count of cells collected from normal mucosa of cigarette smokers with that obtained from non- smokers.

Materials and Methods: In this cross-sectional study, cytologic smears of normal tongue, buccal mucosa and floor of the mouth from 19 smokers and 19 non- smokers were stained for AgNORs. The AgNORs count was established on 100 cells. The count value of groups were compared and analyzed using the Levens, Paired T, Student and Factorial tests. Using P<0.05 as the limit of significance.

Results: The AgNORs were round and had a clustered distribution in both groups. The mean AgNORs count was statistically higher in cells of smokers than non- smokers (P<0.05). There was a significant difference between smears from the floor of the mouth and other anatomical sites in both groups. In this study, no correlation was found between AgNORs count and gender.

Conclusion: Analysis of AgNORs suggests that there might be a correlation between the smoking habit and an increased rate of cellular proliferation in the oral mucosal cells.