Journal of Dental Medicine

Normal 0 false false false EN-US X-NONE AR-SA Cytokines are glycoproteins produced  specifically by lymphocytes, macrophages, monocytes and many other cells. In fact, They act nonspecifically. Cytokines are not immunoglubolins and unlike them, have not high molecular weight. They regulate immuneresponse as well as in diagnosis and treatment of diseases. Cytokines role  in periodontal diseases as well as identifying them in the pathogenesis of some dental and oral diseases and bone loss process is an important issue in dentistry. Hence, this article presents cytokine's role and developments of immunology science in dentistry.

 

Normal 0 false false false EN-US X-NONE AR-SA Recurrent aphthous is a painful condition with 10-12% prevalence in the world. Considerable evidence are existed about the relationship between cellular immune response and recurrent aphthous .In this regard, present study carried out to analyze lymphocyte phenotype in patients with aphthous stomatitis in both active and remission phases of the disease . The results showed CD4 T-lymphocytes are decreased during active phase while there were insignificant changes in CD3 and CD8 T-lymphocytes count compared to normal population. CD4/CD8 ratio was also decreased (P≤0.05). CD16 killer lymphocytes and CD19 cells were increased significantly in active phase of the disease (P≤0.05).