Journal of Dental Medicine

Normal 0 false false false EN-US X-NONE AR-SA Non-removable Keratotic lesions are relatively prevalent in various types in oral mucosa. The treatment modality is often problematic and is done by using  various specific regimens. Bleomycin was used in two primary studies with limited number of patients (N=9) . In current survey, more patients were recruited in a longer period of study. In fact, 50 leukoplakia and lichen planus patients were treated by local administration of belomycin  in a 21 months follow-up period. Statistical analysis was done by using Kaplan meier and cox Regression methods. The obtained results showed that belomycin can remove many of these lesions and can prevent both chronic pattern and malignant changes of the lesions. As In 9 cases of leukoplakia, 2 cases of recurrence were recorded. According to statistical analysis, in case of complete treatment up to 11 months , the recurrence  would not be possible. In 41 cases of lichen planus, recurrence rate was higher and after  a longer period (17 months ) following complete treatment, recurrence was totally eliminated. In fact, Recurrence can be due to psychological conditions. To conclude, local administration of Bleomycin is recommended to use to treat Oral  keratotic lesions and can act successfully based on current study's findings.

  In 1996 Grinspan et al presented the association between primary hypertension and diabetes mellitus as Grinspan Syndrome. Through various studies, Researchers have noticed that epidermal lichen planus cells show enzymatic disorders as well as defective carbohydrate expression. Therefore, it was assumed that there is a relationship between cells and hormones in metabolic actions. Besides, some researchers presented the possible relation between hormonal dysfunction and immunological disorders leading to lichen planus development. It was found that primary hypertension is not related to lichen planus and lichen planus is presented in hypertensive patients as a result of antihypertensive medications. Therefore, the majority of studies in this regard have been focused on diabtese and lichen planus, their prevalence , comparing patients with the control groups and the association between blood sugar, blood fats , antihypertensive drugs and lipid lowering drugs.