Journal of Dental Medicine

  The aim of this review article was to define the mechanism of action and effects of commonly used medications on the tissue remodeling and Orthodontic Tooth Movement (OTM). A review on the effects of medications and dietary supplements on the rate of experimental tooth movement was performed using Cochrane library, Embase and medline (1980-2013). 63 articles were included in this review. 34 of them were related to the effects of hormones and analgesics, were evaluated in this article but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement and medication regimens. Non Steroidal Anti-Inflammatory Drugs (NSAIDs) reduced the rate of tooth movement while non-NSAIDs such as acetaminophen had no effect on the rate of OTM. Corticosteroids, parathyroid hormone and thyroxin increased the rate of tooth movement. Sturgeons might slow OTM, but experimental studies are lacking. Medications might have an important influence on the rate of tooth movement and information on their consumption is necessary to adequately discuss treatment planning with patients.

  Molecules produced in various diseased tissues or drugs and nutrients consumed regularly by patients, can reach the mechanically stressed paradental tissues through the circulation and interact with local target cells. The combined effect of mechanical forces and one or more of these agents may be inhibitory, additive or synergistic. The aim of this review was to outline the mechanisms of action and effects of some commonly used drugs on tissue remodeling and Orthodontic Tooth Movement (OTM). A review on the effects of medications and dietary supplements on the rate of experimental tooth movement was performed using Cochrane library, Embase and Medline (1980-2013). 63 articles were included in the review. 34 of them related to the effects of hormones and analgesics were evaluated in the first part of this review. The rest of them (29 articles) were evaluated in the current review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement and medication regimens. Vitamin D₃ might enhance the pace of tooth movement, but dietary calcium and fluorides appear to reduce the rate of OTM. Bisphosphonates (BPNs) are considered to have marked inhibitory effects on the rate of tooth movement. Nicotine and nitric oxide might effectively increase the speed of OTM. All drugs reviewed had therapeutic effects, as well as side effects, that may influence the cells targeted by orthodontic forces. Therefore, it is imperative that the orthodontist pays close attention to the drug consumption history of each and every patient, before and during the course of orthodontic treatment. When the use of drugs is revealed, their effects and side effects on tissue systems should be explored to determine their potential influence on the outcome of mechanotherapy.