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Investigation of p53 codon72 polymorphism in oral squamous cell carcinoma (SCC) specimens and normal population by PCR
P. Deyhimi, M. Nikbakht Dastjerdi, F. Morsali, Sh. Kazemi,
Volume 21, Issue 1 (14 2008)
Abstract

Background and Aim: A single nucleotide polymorphism at codon 72 of the p53 gene alters the p53 protein structure and affects its activity. This polymorphism depends on geographic regions and race. Also its association with some cancers has been reported. The aim of this study was to investigate this polymorphism in well differentiated oral SCC and normal population in the city of Isfahan.

Materials and Methods: In this case-control study, 20 paraffin blocks of non metastatic and well differentiated oral SCC were selected from the archive of oral pathology department of dental school between 2001 and 2005. 20 whole blood samples from normal people were considered as control group. After DNA extraction, p53 codon 72 polymorphism was determined by polymerase chain reaction (PCR) technique using specific primers of Arg and Pro and agarose gel electrophoresis. Data were analyzed by Fisher's exact test with p<0.05 as the level of significance.

Results: The prevalence of Arg/Arg , Arg/Pro and Pro/Pro genotypes in case group were 45%,45% and 10% respectively compared to 45%,50% and 5% in controls. There was no statistical significant difference in p53 codon 72 genotypes distribution between case and control groups.

Conclusion: Based on the results of this study, p53 polymorphism could not be considered as a genetic predisposing factor for oral SCC development in Isfahan.


Comparative study of the prevalence of radicular cysts and periapical granulomas in young and elderly adult patients referred to Isfahan dental school
Parviz Deyhimi, Saeedeh Khalesi, Ehsan Arefkhani,
Volume 34, Issue 0 (5-2021)
Abstract
Background and Aims: Periapical diseases are the end result of untreated pulpitis and necrotic dental pulp. The aim of this study was to determine and compare the prevalence of radicular cysts and periapical granulomas in young adults and old patients referred to Oral Pathology department of Isfahan dental school.
Materials and Methods: In this cross-sectional study, all recorded samples with a diagnosis of radicular cyst and periapical granuloma were considered by the census method in a 14-year period from 2006 to 2019 in the archives of the Oral Pathology Department of Isfahan dental school. The data were extracted including age, gender, location of the lesion and histopathologicaldiagnosis.
The prevalence of cases in terms of age range was classified into two groups of young adults (20-35 years) and older (over 50 years). Then, Chi-square test and t test were done using SPSS24 and P<0.05 was considered significant.
Results: The results showed that 49.4% (430 cases) of lesions were observed in males and 50.5% (439 cases) in females. Of all lesions, 51% (444 samples) were periapical granulomas and 49% (426 samples) were radicular cysts. Chi square test showed a significant difference between the prevalence distribution of the two lesions based on gender. Radicluar cysts were more prevalent in males and periapical granulomas were more prevalent in females (P<0.001). According to t-test, there was no significant difference between the mean age of patients based on gender (P=0.176). The prevalence of lesions in the third and fourth decades of life was higher than in other decades. Also, in the third and eighth decades, the prevalence of periapical granulomas was higher than radicular cysts.
Conclusion: The prevalence of periapical cysts and dental granulomas were higher in young adults than in elderly patients.

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