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Influence of medication on the rate of orthodontic tooth movement (Part 1: hormons and corticosteroids)
Mirhashemi Amirhossein , Geramy Allahyar , Sodagar Ahmad , Baghaeian Pedram ,
Volume 28, Issue 1 (5-2015)
Abstract

  The aim of this review article was to define the mechanism of action and effects of commonly used medications on the tissue remodeling and Orthodontic Tooth Movement (OTM). A review on the effects of medications and dietary supplements on the rate of experimental tooth movement was performed using Cochrane library, Embase and medline (1980-2013). 63 articles were included in this review. 34 of them were related to the effects of hormones and analgesics, were evaluated in this article but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement and medication regimens. Non Steroidal Anti-Inflammatory Drugs (NSAIDs) reduced the rate of tooth movement while non-NSAIDs such as acetaminophen had no effect on the rate of OTM. Corticosteroids, parathyroid hormone and thyroxin increased the rate of tooth movement. Sturgeons might slow OTM, but experimental studies are lacking. Medications might have an important influence on the rate of tooth movement and information on their consumption is necessary to adequately discuss treatment planning with patients.


The effect of medication on the rate of orthodontic tooth movement (Part 2: Mediators and other drugs)
Amirhossein Mirhashemi, Allahyar Geramy, Ahmad Sodagar, Pedram Baghaeian, Yasamin Jalali,
Volume 28, Issue 2 (7-2015)
Abstract

  Molecules produced in various diseased tissues or drugs and nutrients consumed regularly by patients, can reach the mechanically stressed paradental tissues through the circulation and interact with local target cells. The combined effect of mechanical forces and one or more of these agents may be inhibitory, additive or synergistic. The aim of this review was to outline the mechanisms of action and effects of some commonly used drugs on tissue remodeling and Orthodontic Tooth Movement (OTM). A review on the effects of medications and dietary supplements on the rate of experimental tooth movement was performed using Cochrane library, Embase and Medline (1980-2013). 63 articles were included in the review. 34 of them related to the effects of hormones and analgesics were evaluated in the first part of this review. The rest of them (29 articles) were evaluated in the current review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement and medication regimens. Vitamin D3 might enhance the pace of tooth movement, but dietary calcium and fluorides appear to reduce the rate of OTM. Bisphosphonates (BPNs) are considered to have marked inhibitory effects on the rate of tooth movement. Nicotine and nitric oxide might effectively increase the speed of OTM. All drugs reviewed had therapeutic effects, as well as side effects, that may influence the cells targeted by orthodontic forces. Therefore, it is imperative that the orthodontist pays close attention to the drug consumption history of each and every patient, before and during the course of orthodontic treatment. When the use of drugs is revealed, their effects and side effects on tissue systems should be explored to determine their potential influence on the outcome of mechanotherapy.


Assessment of the dentoskeletal changes following the use of twin-block functional appliance and inclined anterior bite plan in the patients with class II malocclusion div 1 in 11-14 years old
Allahyar Geramy, Amir Hossein Mirhashemi, Sahar Rafiei Chokami, Ahmadreza Shamshiri,
Volume 28, Issue 3 (10-2015)
Abstract
Background and Aims: Cl II malocclusion is one of the most common abnormalities in human societies and using a simple, affordable and accessible treatment that can be provided by general practitioners or specialists, to prevent future malocclusion complications is vital. Cl II malocclusion treatment using functional appliances such as twin block and anterior inclined bite plan have less cost, side effects and complications compared to fixed orthodontic or orthosurgery. Until now, the dentoskeletal changes resulting from the application of twin block and anterior inclined bite plan in patients with Class II malocclusion has not been evaluated. The objective of the present study was to assess the dentoskeletal changes following the use of twin-block functional appliance and inclined anterior bite plan in the patients with class II malocclusion div 1 during mixed dentition.

Materials and Methods: In this retrospective cohort trial, 60 patients with the definitive diagnosis of Class II div. 1 malocclusion having ANB>2 and FMA angel between 20 and 30 and without any previous treatment or syndrome who were treated with twin-block or inclined anterior bite plan appliance were selected and their lateral cephalometries were traced before and after treatment. Selected distance and angular landmarks were measured on the cephalograms with the good reliability (ICC=0.953) and the changes occurred in the landmarks were statistically analyzed using Student t test.

Results: Due to the increased mandibular growth, most of the landmarks experienced significant changes following the treatment with twin-block and inclined bite plan (P<0.05). The appliances corrected Class II malocclusion through improvement of mandibular length and position, maxillary and mandibular skeletal and dental relationships (decreased ANB angle and overjet) and stability of mandibular plan inclination. No significant differences were found between the devices regarding most landmarks changes (P>0.05), however, SNA (P=0.04), overjet (P=0.007) and wits appraisal (P=0.004) changed differently after using the appliances.

Conclusion: Despite with most similarities of both twin-block and anterior inclined bite plan to correct class II div. 1 malocclusion, Due to the advantages of anterior inclined bite plan such as less size, good patient cooperation and simple laboratory preparations the appliance can be used as substitute for complex functional appliances to correct class II div. 1 malocclusion before the growth spurt.


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