Showing 4 results for Ghalyani
P. Ghalyani ,
Volume 8, Issue 2 (9 1995)
Abstract
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AR-SA In present article, in order to evaluate the
role of genetics in the etiology of lichen planus, 14 patients (6 with familial
history of lichen planus and 8 without any history of the disease in family)
were selected. HLA antigens (class 1, class 2, B, C) were analyzed by
lymphocytotoxicity NIH two stage methods. The patient's age range was 24-66. In
our study, although patient's quantity cannot represent Iranian population and
therefore we cannot report antigen prevalence, we can state that in our sample
a relative increase in HLA B5 or B5 cluster was found.
J. Koiahi-E-Kazerani , P. Ghalyani Isfahani , J. Varshosaz ,
Volume 16, Issue 2 (8 2003)
Abstract
Chlorhexidine is bonded well to the oral mucosa and dental pellicle and is poorly absorbed from the astrointestinal tract, but in high concentration it is absorbed enough to produce liver necrosis. In this case a dentistry student accidentally ingested a shot of 20% chlorhexidine gluconate solution. Treatments included washing the oral cavity with lots of tooth paste, drinking of 5% alginate syrup and ingestion of 5g small pieces of cork .The following adverse effects were experienced: headache, giddiness, mild mist, euphoria, stomachache, diarrhea and complete loss of taste sensation for 8h, which recurred gradually during the last 48 hours. According to the poor absorption, low toxicity and low concentration of conventional mouthwashes, systemic toxicity following drinking of some shots of this solution is rare. Ultimately if may cause gastritis. Other treatments which are helpful in the same cases are: drinking of hard water, kaolin and tragacant syrup, bicarbonates such as baking soda, carbonates such as beverage , citrates such as lemon-juice and chlorides such as brine and so on.
P. ghalyani Isfahani , Sa. Keyhan , A. Shirani ,
Volume 16, Issue 2 (8 2003)
Abstract
Statement of Problem: Ultrasonic Scaling is one of the main sources of producing infected aerosols in dentistry. These aerosols are able to spread pathogens such as microorganisms associated with tuberculosis, conjunctivitis, influenza and other respiratory diseases, herpetic and other skin diseases, ADIS and hepatitis B.
Purpose: The aim of this study was to investigate the clinical effectiveness of an aerosol- reduction device attaching to ultrasonic scaler handpiece.
Materials and Methods: In this experimental study 18 patients participated. Randomly, mandibular and maxillary quadrants of one side, in each subject, were scaled using an ultrasonic scaler with aerosol-reduction device for 5 minutes. After 30 minutes, another quadrant was scaled by ultrasonic scaler without aerosol- reduction device. In order to determine the effectiveness of aerosol- reduction device, blood agar plates attached to the surgical mask of the operator, 30 cm far from the patient's mouth, were incubated in 37°c for three days and the colonies were counted. Median, Interquartile eange and Wilcoxon test, at the 0.05 level of significance, were used to analyze the data.
Results: The median and interquartile range for the number of colony forming units (CFUS) without aerosol- reduction device was 17.5 (8, 24), while the median for the number of CFUS when using aerosol-reduction device was 0 (0, 1), indicating significant statistical difference (PO.001)
Conclusion: The aerosol- reduction device significantly reduces the amount of aerosols produced during ultrasonic scaling.
G. Kolahi Kazerani , P. Ghalyani , J . Varshosaz ,
Volume 16, Issue 3 (10 2003)
Abstract
Statement of Problem: The role of the microbial plaque in caries etiology and periodontal diseases has been proved and the mechanical methods for plaque control have special limitations, consequently, chemical methods have been suggested. One of the most effective materials is Chlorhexidine Gluconate that is commonly used as mouth rinses. However, the medicated formulations of chewing gums, due to several properties, have been paid attention. It should be noted that a new formulation to satisfy the consumers' taste seems necessary.
Purpose: The aim of this study was to present a new formulation for chewing gums containing chlorhexidine to achieve a pleasant taste coupled with their effectiveness and anti-plaque properties maintenance.
Materials and Methods: In this double blind, crossover, prospective clinical trial, 18 volunteers were investigated. Chlorhexidine Gluconate was used and added to the gum-base by Manitole. In order to cover the bitter taste of the drug Aspartam, mint essence and Mentole were used. After gums production, the profile of drug dissolution was evaluated by jaw movement simulating system. It took 5 days to study each type of chewing gums without any mechanical plaque control method. Medicated and placebo chewing gums were identical in shape, size, color and formulation. The washout period was 2 days. Chewing gums were used every 12 hours for 20 minutes. To determine plaque score, Turesky- Gilmore- Glickman modification index was used. Other variables including: subjective evaluation of taste, cleansing effect and taste disturbance were assessed through filling a checklist. The data were analyzed by Paired t test and Wilcoxon test.
Results: During 20 mins, 80% of the drug was released from the gum-base. The mean difference of plaque score between the initial and final stages at the first trial was -0.1589 and at the second trial was 2.994 which was statistically significant (P<0.001). Subjective evaluation of cleansing effect showed statistically significant differences between the placebo and medicated chewing gum (PO.00I). There was no statistical significant difference between the subjective evaluations of taste (P-0.157). No taste disturbances were reported.
Conclusion: In this investigation, the researchers could for the first time introduce new formulation for chlorhexidine medicated chewing gums with efficacy and anti-plaque effects coupled with an acceptable taste for public usage.
