Journal of Dental Medicine

Normal 0 false false false EN-US X-NONE AR-SA In order to evaluate the effect of chlorhexidine mouthwash in controlling oral complications of chemotherapy, 146 patients were recruited among the patients referred to heamatology department of Shariati hospital who were under treatment by routine chemotherapic drugs like EBDV, CMF or FU-Lucoverin5 for first, second or third time. The patients were  allocated into two groups to receive either chlorhexidine or Placebo  for a week after careful examination and evaluation. Finally, It was concluded that Chlorhexidine is effective to reduce oral complications of chemotherapy (P-value≤0.002).

Background and Aim: Oral lichen planus is a chronic mucocutaneous disease with various clinical expressions. The histopathologic features are not characteristic and may be seen in other diseases. The aim of this study was to determine the clinical and pathologic features of oral lichen planus in oral pathology department of dental school, Tehran university of medical sciences.

Materials and Methods: In this case series study, archive of oral pathology department from 1968 to 2002 was reviewed and cases diagnosed as lichen planus and related lesions selected. The diagnosis of oral lichen planus was confirmed by evaluation of microscopic slides. Clinical informations such as age, sex, site and duration of lesions and differential diagnosis as well as microscopic findings were recorded. Data were analyzed with SPSS software using t student, ANOVA, Chi-square and Post Hoc Tukey tests with p<0.05 as the limit of significance.

Results: From a total of 402 cases recorded as lichen planus and related lesions, 251 cases were confirmed for final analysis. The mean age of patients was 42 years (5 to 83 years). 50.4% of cases were men and 49.6% women. The most prevalent clinical type was the ulcerative form and the mean duration of disease was 18.4 months. Buccal mucosa was most frequently involved followed by the tongue and gingiva. A white patch, Wickham’s striae and mucosal erythema were the most prevalent clinical appearance and parakeratosis , orthokeratosis and eosinophilic band the most frequent microscopic features.

Conclusion: Based on the results of this study, the correlation of clinical and pathological findings in the proper diagnosis of oral lichen planus is emphasized.

Background and Aim: The cell cycle is an important event in tumor growth and differentiation and several molecules are involved in this process. The aim of this study was to evaluate the expression of cyclin D1 (a cell cycle inducer) and p21 (a cell cycle inhibitor) in ameloblastoma of the jaws.

Materials and Methods: In this cross-sectional study, 40 cases of ameloblastoma were selected from the archive of oral pathology department. 3 micron sections were cut from paraffin blocks and immunohistochemically stained with antibody against cyclin D1 and p21waf. Stained cells were counted using an eyepiece graticule and labeling index was calculated. Data were analyzed by SPSS version 11.5 for windows using Mann-Whitney and Wilcoxon signed ranked tests with p<0.05 as the level of significance.

Results: Expression of cyclin D1 protein was detected in nuclei of many tumoral cells. The expression of cyclin D1 in solid and unicystic ameloblastoma and also between its follicular and plexiform variants was not statistically different (P>0.05). There was no statistically significant difference in expression of cyclin D1 between peripheral and central cells (P>0.05). Expression of p21 protein was detected in nuclei of some tumoral cells. There were no statistically significant differences between p21 expression in unicystic and solid ameloblastoma (P>0.05). P21 expression was statistically different between plexiform and follicular variants of ameloblastoma (P=0.049). The difference between p21 expression in peripheral cells of plexiform and follicular variants was statistically significant (P=0.009). This was not observed in central cells. There was no statistically significant relation between p21 and cyclin D1 expression in ameloblastoma (P>0.05).

Conclusion: Based on the results of this study, cyclin D1 expression in ameloblastoma is in high level and it could have an important role in the process of tumorigenesis. P21 expression in ameloblastoma is very faint and its possible effects need further investigation.

  Background and Aims: Dental implants have been studied for replacement of missing teeth for many years. Productivity of implants is extremely related to the stability and resistance under applied loads and the minimum stress in jaw bone. The purpose of this study was to study numerically the 3D model of implant under thermal loads.

  Materials and Methods: Bone and the ITI implant were modeled in “Solidworks” software. To obtain the exact model, the bone was assumed as a linear orthotropic material. The implant system, including implant, abutment, framework and crown were modeled and located in the bone. After importing the model in Abaqus software, the material properties and boundary conditions and loads were applied and after meshing, the model was analyzed. In this analysis, the loads were applied in two steps. In the first step, the mechanical load was applied as tightening torque to the abutment and the abutment was tightened in the implant with 35 N.cm torque. In the second step, the thermal load originated from drinking cold and hot water was applied as thermal flux on the ceramic crown surface in this model.

  Results: Thermal analysis results showed that the thermal gradient in the bone was about 5.5 and 4.9 degrees of centigrade in the case of drinking cold and hot water respectively , although the maximum gradient of the whole system was reduced to 14 degrees, which occurred, in the crown by drinking cold water.

  Conclusion Thermal stresses were so small and it was because of the low thermal gradient. Maximum stresses occurred in the abutment were due to the tension preloads which were originated from the tightening torque.

Background and Aims: Type 1 diabetes mellitus, is the most common metabolic disorders in children and adolescents. The aim of this study was to assess the state of oral health in children with type 1 diabetes compared with healthy children in 2013-2014 in Hamadan province, Iran.

Materials and Methods: The specimens were selected through convenience sampling in two groups. Group one consisted of 80 individuals (5-18 years old; case group), suffering from type 1 diabetes mellitus referred to the Pediatric endocrine clinic. Control group consisted of 80 non-diabetic healthy children who were out- patients of pediatric and orthodontic department of Hamadan dental school. Two groups were similar in age and sex. The data were collected through a questionnaire, medical records and clinical examination. DMFT, dmft, GI and PI indices were assessed in each patient. Data were analyzed using ANOVA and T-test.

Results: In spite of similarity in oral hygiene habits in both group, there was no significant difference in mean DMFT and permanent decayed teeth in both groups (P>0.05), but the mean dmft (P<0.008) and primary decayed teeth (P<0.011) in the control group was significantly higher than that of the case group. Also, diabetic patients had significantly more gingival inflammation (P<0.05). The mean PI in the two groups did not differ significantly. Oral hygiene habits were similar in both groups but diabetic patients were significantly referred to dentists with lower frequency then that of control group (P=0.00).

Conclusion: The devastating effects of diabetes on the oral health, along with other side effects can be effective in promoting tooth decay and gingivitis in diabetic patients. Unfortunately, oral health care and programmed dental visit were not the priority for the diabetic patient (and parents) involved in our study. Therefore, programs to increase awareness and encourage patients for a better control of their oral health in order to diminish diabetes' devastating effects is recommended.