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Showing 3 results for Khatibi
Evaluating the effects of chlorhexidine in periodontal treatments
M. Mosavi Jazi, F. Khatibi ,
Volume 10, Issue 1 (8 1997)
Abstract

Normal 0 false false false EN-US X-NONE AR-SA There has been many efforts to use antimicrobial agents in order to control microbes causing periodontal diseases since they play an integral role in the etiology of periodontal diseases. Chlorhexidine is a ADA approved antimicrobial and antiplaque mouthwash that is used to treat gingivitis. It acts by intense adhesion to the most sites of the oral cavity and is slowly released providing a long-lasting bactericidal environment that can result in lower plaque formation. Therefore, The risk of gingivitis and periodontal disease would be declined.


Evaluation of Serum TNF-a in Patients with Oral Keratotic Lichen Planus and Comparing with Healthy Cases
Sh. Jafari , M. Khatibi ,
Volume 13, Issue 1 (6 2000)
Abstract

: Oral lichen planus (OLP) is a chronic and common disease of the oral mucosa, which its etiology, phathogenesis and exact treatment is not definitely known. T-cell mediated immunity is the most probable factor in pathogenesis of OLP. Since TNF-a primarily, as a cytokine, interfers T-Cel mediated immunopathologic reactions, it may also interfere with pathogenesis of OLP.In an observational case- control study, the values of TNF-a in serum of OLP patients were measured and compared with the values of healthy cases. 30 OLP patients and 30 healthy controls have examined with ELISA technique. Data was obtained by observation questionnaire and examination.The mean value of TNF-a in case and control groups were 26.2 and 7.9 pg/ml, respectively, which showed significant difference (PO.005).Considering the TNF-a values with respect to sex and age did not show any significant difference,however the lower TNF-a value was obtained with increasing the age, and higher value observed in females. Higher values of TNF-a found in OLP patients compared with control group. It means TNF-a is an effective factor in OLP. Due to these findings new treatment protocols have been suggested.


The comparison between low level infra-red laser and triamcinolone acetonide mouth rinse in treatment of oral lichen planus lesions
Mandana Khatibi, Arash Azizi, Abbas Kamali, Soheila Mohammadian,
Volume 31, Issue 2 (9-2018)
Abstract
Background and Aims:The erosive and ulcerative forms of Oral lichen planus causes pain and irritation, affects the nutrition and biological quality of the patient. Considering the high prevalence of the disease, the complications of conventional treatments and the resistance to classical drug therapy, the aim of this study was to compare the effect of infrared low level laser and triamcinolone acetonide mouth rinse on treatment of oral lichen planus lesions.
Materials and Methods:In this double blind clinical trial, 24 patients were selected randomly according to the inclusion and exclusion criteria and divided into two groups of 12. Before and after the study, pain and burning sensation index (VAS), apparent shape and score of the lesion and size of the lesion were recorded in the patients. We treated the first group with low level infrared laser (810 nm) twice a week with 0.5-2 j/cm2 energy density and 300 mW/cm2 power density up to a maximum of 10 sessions. For the second group, we prescribed a mouth rinse of triamcinolone acetonide 0.2% four times a day with antifungal drugs for a month. Then, the study`s criteria were recorded after the completion of treatment. All data were statistically analyzed using the repeated measure ANOVA test to compare the quantitative changes over time, The Mann-Whitney U test was used to compare the rank variables between two groups at any time and Friedman test for each group between different times.
Results: There was no significant difference between the groups in terms of severity of pain (P=0.255), score and size (P=0.186), and appearance (P=0.178) of the lesions among two groups. Although the two groups showed a significant decrease in all three indicators.
Conclusion:Considering that in both groups, all three indices were improved and these improvements were similar, it seems that laser therapy can be effective. It could be used as a therapeutic alternative in treating patients with OLP (Oral Lichen Planus) especially in cases with contraindication in corticosteroid administration or lack of appropriate therapeutic response or when there is resistance to treatment.

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