Journal of Dental Medicine

This study was perfomed on twenty five teeth which showed radiographic lesions( 6mm over 25 mm). the teeth were arranged in seven different groups and root canal therapy ( by warm Gutta-percha technique) as surgical intervention were performed at various time intervals. In this investigation, histologic studies of the periapical tissues begin shortly after elimination of the root canal system with or without root  canal obturation. This healing demonstrated with a) replacement of granulation tissue by connective tissue, inflammatory cells diminish in number and density
b) fibroblastic activity and their differentiation of osteoblast
c) osteoblastic activity forming osteoid and trabecular bone. The newly formed trabeculae extend from the periphery of the lesion to the center and root surfaces
d) nonorganized periodontal ligament fibers return to their original orientation soon after the newly formed trabeculae reach the apical root surface and form lamina dura
Inflammatory responses may continue simultaneously with periapical tissue regeneration and bone formation. Chronic inflammatory cells seem to be present occasionally in marrow spaces of the newly formed bone. Cellular activity and bone formation are demonstrated in the presence of the lining epithelium. This is seen between newly formed bone and apical root tip and might be suggestive of healing of the periapical cyst.

Normal 0 false false false EN-US X-NONE AR-SA Endodontic treatments are based on complete cleansing of root canal as well a multidimensional obturation especially in apical foramen area.  This study was done to analyze  the reactions of periradicular tissues to filling materials in case of  overobturation in endodontic treatments and healing despite extra filling material existence in periradicular tissues. 25 teeth with periradicular lesions (endodontic origin) in patients of 13-85 years were selected. 7 groups were formed based on the time of performing surgical biopsy on the teeth.  In 80% of the cases, despite existing extra materials in periradicular tissues, 100% bone healing as well as collagen formation was observed. Besides, some Giant cells and hemosiderine were found around the areas containing sealer.

Normal 0 false false false EN-US X-NONE AR-SA In order to evaluate quality of apex filling materials in endodontic surgeries, studies on extracted teeth were conducted.  The teeth were selected and after crown dissection, root canal therapy was done by gutta-percha and simple technique.  Afterwards, for each tooth 3mm of root apex was cutted and then the samples were divded into 5 groups of 15 samples.two groups of 3 samples were regarded as control groups. Then, a 3mm cavity was made in apex and were filled by amalgam ( vivdent^TM or Sina ^TM), cavit and coltosol in groups number 2 to 5. The gutta-percha was condensed by a round end tool. The samples were placed in Methylen blue for 48 hours and then by scrubbing lateral walls of the teeth, the penetration of color into root canal space was evaluated by steromicroscope. The obtained results showed that Coltosol was acted better and resulted in more significant changes compared to Amalgam vivident^TM, Sina^TM , Cavit and Gutta-percha.(P≤0.001)