Journal of Dental Medicine

Postoperative pain following Root Canal Therapy (RCT) is the common problem for patients,dentist and dental staff. Regardless of cause it appears that postoperative pain and discomfort is related to periapical inflammation. The purpose of this study was to investigate histologically the effect of Ibuprofen on acute apical inflammation following RCT. on cat. Fifty-six cuspids teeth of 14 cats were divided into three groups, 6 cats for experimental group, 6 cats for positive control group and 2 cats for negative control group. In first group, to anesthesize the animals each cat received 10 mg/kg Ibuprofen 36 hours before RCT and repeated every 24 hours. In second group RCT was performed in 24 cat teeth without any prescription. In negative control groups 2 cats, no RCT were done.Following vital perfusion, in interval of 6, 12, 24 hours, samples were post fixed in 10% formalin and five micron sections were prepared, and stained with H&E and studied under the Mann Whitney parameter test. Infilteration of inflamatory cells in 6 hours interval in experimental group was significantly less than two control groups. In 12 hours samples, however, inflammation in experimental group reduced, but it was not significant. In 24 hours samples there was no significant difference between experimental groups and controls. The result of this in-vivo study shows prescription of Ibuprofen before root canal therapy can reduce inflammatory reaction.

Background and Aims: Instrumentation of the root canals results in formation of smear layer which covers the dentinal tubules. In infected teeth, it is ideal to achieve a material that has the ability to remove the smear layer besides antimicrobial activity. Therefore, this study was designed to evaluate the antimicrobial effect of Citrus aurantifolia extracts (lime juice and rind extract) on Enterococcus faecalis within dentinal tubules in the presence of smear layer.
Materials and Methods: One-hundred and forty dentin tubes were prepared from bovine incisors. After removal the smear layer, the specimens were infected with Enterococcus faecalis. Then, the smear layer was reformed. Test solutions were used as the irrigants in study roups as follows: group 1: 5.25% NaOCl group 2: 17% EDTA group 3: NaOCl+EDTA group 4: Lime juice group 5: ethanolic rind extract of C.aurantifolia group 6: 96% ethanol. Dentin chips were collected from inner and outer layers of dentinal walls and optical density was measured. The data were analyzed using one-way ANOVA and Tamhane tests.
Results: In outer layer of dentin, the efficacy of rind extract was less than that of NaOCl+EDTA (P<0.05). Also Lime juice was less effective than EDTA, NaOCl and NaOCl+EDTA (P<0.05). In inner layer of dentin, Lime juice was significantly less effective than NaOCl and NaOCl+EDTA (P<0.05). The efficacy of rind extract was less than that of NaOCl+EDTA (P<0.05).
Conclusion: In the presence of smear layer, the antimicrobial activity of Lime juice was less than that of NaOCl but the efficacy of rind extract was similar to that of NaOCl.