Sa. Miremadi , Ar. Rokn , A. Nikbakht ,
Volume 15, Issue 4 (9 2003)
Abstract
In the past two decades, replacement of the missing teeth with implant borne prosthesis has become a treatment modality, accepted by the scientific community for fully and partially edentulous patients. The aim of the present study is to evaluate retrospectively, 502 ITI dental implants application, in partial and complete edentulous patients, treated in two private centers, based on clinical and radiographic parameters.One hundred and forty patients, with 502 ITI dental implants, who were treated from 1994 to 2000 in two private centers, were investigated. For such patientsT a minimum of one year and a maximum of six years were passed since prosthesis placement over implants, so they were cooperative subjects. There was a significant relation between implant type and bone loss, so was between the presence and absence of BOP and the rate of bone loss. From totality 502 implants, 6 implants (28%) and 4 implants (1.4%) were lost, in maxilla and mandible, respectively. The total success rate was 98%. This rate, in maxilla with 212 implants was 97.2% and in mandible with 90 implants was 98.6%. The mean value of bone loss (RBL) and periodontal pocket depth (PPD) during 6 years, for the remaning 492 implants were 0.93±0.39mm and 1.99mm, respectively. The results showed that ITI dental implants, with a success rate of more than 97%, can be used as a desirable treatment choice in partial and complete edentulous patients.
P. Deyhimi, M. Nikbakht Dastjerdi, F. Morsali, Sh. Kazemi,
Volume 21, Issue 1 (14 2008)
Abstract
Background and Aim: A single nucleotide polymorphism at codon 72 of the p53 gene alters the p53 protein structure and affects its activity. This polymorphism depends on geographic regions and race. Also its association with some cancers has been reported. The aim of this study was to investigate this polymorphism in well differentiated oral SCC and normal population in the city of Isfahan.
Materials and Methods: In this case-control study, 20 paraffin blocks of non metastatic and well differentiated oral SCC were selected from the archive of oral pathology department of dental school between 2001 and 2005. 20 whole blood samples from normal people were considered as control group. After DNA extraction, p53 codon 72 polymorphism was determined by polymerase chain reaction (PCR) technique using specific primers of Arg and Pro and agarose gel electrophoresis. Data were analyzed by Fisher's exact test with p<0.05 as the level of significance.
Results: The prevalence of Arg/Arg , Arg/Pro and Pro/Pro genotypes in case group were 45%,45% and 10% respectively compared to 45%,50% and 5% in controls. There was no statistical significant difference in p53 codon 72 genotypes distribution between case and control groups.
Conclusion: Based on the results of this study, p53 polymorphism could not be considered as a genetic predisposing factor for oral SCC development in Isfahan.
