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Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane
M. Ashoori , A. Salimian , N. Jalayer Naderi ,
Volume 19, Issue 4 (6 2007)
Abstract

Background and Aim: Microscopic differentiation between well differentiated squamous cell carcinoma and verrucous carcinoma is very difficult. As these lesions have different clinical course and treatment a reliable method to help distinguish between them is necessary. The basement membrane in oral verrucous carcinoma is generally intact whereas in oral squamous cell carcinoma is mostly discontinuous. This structure can be studied by different methods. The aim of this study was to differentiate these lesions with special staining of basement membrane.

Materials and Methods: In this tests evaluation study, a total of 26 cases consisting of 15 oral squamous cell carcinomas and 11 oral verrucous carcinomas were retrieved from Cancer Institute of Imam Khomeini hospital archive of pathology and their paraffin blocks were cut and stained with Periodic Acid Schiff method. Slides were studied with light microscope to evaluate the continuity of basement membrane. Sensitivity and specificity of this method were calculated.

Results: The sensitivity of this method for differentiating oral squamous cell carcinoma from oral verrucous carcinoma was 100% whereas the specificity was 90.9%. Positive predictive value was 93.75% and negative predictive value 100%.

Conclusion: Based on the results of this study, the sensitivity of this test for diagnosis of oral squamous cell carcinoma was high (100%). Further studies are needed to evaluate the use this method for distinguishing oral verrucous carcinoma from oral squamous cell carcinoma.


Cephalometric evaluation of tongue position and oropharynx space in children treated with Twin-block appliance
Sarvin Sarmadi, Behrad Tanbakuchi, Javad Chalipa, Fahimeh Salimi, Mehrdad Panjnoosh,
Volume 31, Issue 1 (6-2018)
Abstract
Background and Aims: Functional therapy locates the mandible in a more anterior and inferior position. Tongue posture and oropharynx space have a considerable relationship with mandibular posture. The aim of the present study was to determine the changes of tongue posture and oropharynx space following treatment with Twin block appliance in adolescent patients with class II division 1 ma1occlusion.
Materials and Methods: Twenty two patients (14 girls mean age:11.5, 8 boys mean age:12.5 years) who were treated with twin-block appliance were enrolled. Cephalograms were used to assess the linear measurements. Graber pattern and McNamara parameter were used to evaluate the tongue posture and oropharynx space, respectively. Data analysis was performed by paired t-test.
Results: The findings of the present study showed a significant increase in anterior position of tongue (P=0.06). Oropharynx space was increased significantly (P<0.001). There was a significant correlation between the decrease of ANB and anteroposterior increase of oropharynx space.
Conclusion: Twin-block appliance caused considerable forward movement of tongue and significant increase of oropharynx space in the sagittal plan.

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