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Preparation and in vitro evaluation of 2 composite scaffolds containing Gelatin for hard tissue engineering applications
Hanieh Nojehdehyan, Maryam Torshabi, Fahimeh Sadat Tabatabaei,
Volume 27, Issue 3 (9-2014)
Abstract

  Background and Aims: Until now, different types of scaffolds are presented for hard tissue engineering and the research continues to find the best scaffold. The aim of this study was to prepare scaffolds using two types of composite materials, ChitosanTriCalcium Phosphate (C/TCP) and ChitosanTriCalcium Phosphate/ Hydroxy apatite (C/TCP/ HA) and to add either 10% or 20% gelatin to compare their influence on swelling ratio of the scaffolds and on their affinities towards Dental Pulp Stem Cells (DPSCs).

  Materials and Methods: Composite scaffolds containing 10 or 20 percent of gelatin were prepared by freeze drying method. To determine the percentage of water absorption, swelling ratio studies were performed. Cell attachment and cell viability of the composite scaffolds were studied using Scanning Electron Microscopy (SEM) and MTT ( dimethyl-thiazol-diphenyltetrazolium bromide ) assay. Data were analyzed using ANOVA and Turkey’s post hoc test. A P-value of <0.05 was considered to be statistically significant.

  Results: The C/TCP scaffold and scaffolds containing 20% gelatin showed good swelling character. The macroporous composite scaffolds exhibited different pore structures. The biological response of DPS cells on C/TCP scaffold, C/TCP scaffold containing 20% gelatin, and C/TCP/HA scaffold was superior in terms of cell attachment, proliferation, and spreading compared to the other scaffolds (P<0.05).

  Conclusion: Considering the limitations of this in vitro studies, the results demonstrated that enhanced gelatin content in the C/TCP scaffolds do not improve initial cell adhesion and proliferation of the DPSCs on these scaffolds.


The effect of adding fluorinated graphene nanoparticles on fluoride release in a commercial fissure sealant: an in vitro study
Rezvan Arian, Namazi, Hanieh Nojedehian, Farhood Najafi, Zahra Yadegari, Roxana Karbaschi, Maryam Torshabi, Sarvin Soleimanpoor,
Volume 37, Issue 0 (3-2024)
Abstract
Background and Aims: Using fissure sealant is one of the most effective methods of preventing pit and fissure decay. Fluoride has been added to various materials as a known anti-caries agent. Fluorinated graphene (FG) has gained attention due to its unique properties. The specific structural characteristics of graphene fillers, besides having antibacterial properties by increasing the rate of fluoride release and charge and neutralizing the acidic pH of the environment, is a suitable option in many treatments. This study investigated the effect of addition of fluorinated graphene nanoparticles on the fluoride release in Fissurit®, a commercial fissure sealant.
Materials and Methods: In this in vitro study, fluorinated graphene oxide (FGO) with bright white color was prepared. After synthesis, 0, 1, 2 and 4 by weight percent were added to the fissure sealant (Fissurit®). Then, the release of fluoride in this material was measured and compared with the commercial fissure sealant containing fluoride (Fissurit®).
Results: According to the obtained results, the amount of fluoride released from groups with different percentages of FGO had a direct relationship with the percentage of FGO addition. Also, at different times, there was a significant difference between the groups with FGO and the control group without FGO (P<0.001).
Conclusion: Addition of FGO to the fluorinated fissure sealant caused the release of fluoride and the possibility of recharging it. The power of releasing fluoride and its recharging in fissure sealant with FGO was higher than the fluorinated fissure sealant, but its fluoride was discharged at a faster rate.

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